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Perinatal period cytokines related to increased risk of future allergy development

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Abstract

Testing of cytokine levels in colostrum, cord blood and amniotic fluid of healthy and allergic mothers and their newborns (using protein microarrays and quantitative analysis by ELISA) revealed differences in the levels of IL-5, IL-10, TGF-β, TNF-α, EGF and eotaxin between healthy and allergic groups. Significantly higher concentration of IL-5 and IL-10 in the colostrum of allergic mothers and cord blood of their children and also tendency to a higher level of IL-4 found at allergic mothers and their children (but without statistical significance) indicate a bias to TH2 response in this group. The higher level of TGF-β in the colostrum of healthy mothers should be involved in beneficial immunological tuning of their children including enhanced IgA formation and better intestine maturation. In amniotic fluid, concentration of TGF-β was higher in children of allergic mothers. A significantly higher level of EGF was proved in the colostrum of healthy mothers and in cord blood of their children in comparison with allergic group. EGF deficiency in the allergic group could impair or delay intestine maturation and support thus allergy development.

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Abbreviations

EGF:

epidermal growth factor

ELISA:

enzyme-linked immunosorbent assay

GIT:

gastrointestinal tract

GRO-α:

growth related oncoprotein α

IL:

interleukin

IFN-γ:

interferon γ

MCP-1:

monocyte chemotactic protein-1

MIP-1δ:

macrophage inflammatory protein 1δ

PDGF-BB:

platelet-derived growth factor BB

RANTES:

regulated upon activation, normal T-cell expressed and secreted

SEM:

standard error of the mean

TGF-β:

transforming growth factor β

TH :

helper T-lymphocyte

TNF-α:

tumor necrosis factor α

VEGF:

vascular endothelial growth factor

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Authors and Affiliations

  1. Institute of Immunology and Microbiology, Ist Faculty of Medicine, Charles University in Prague, 128 00, Prague, Czechia

    J. Žižka, O. Novotná, I. Staňková, I. Šterzl & L. Prokešová

  2. Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20, Prague, Czechia

    M. Kverka

  3. Pediatric Department, Institute for the Care of Mother and Child, 147 00, Prague, Czechia

    R. Lodinová-Žádníková & I. Kocourková

Authors
  1. J. Žižka
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  2. M. Kverka
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  3. O. Novotná
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  4. I. Staňková
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  5. R. Lodinová-Žádníková
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  6. I. Kocourková
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  7. I. Šterzl
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  8. L. Prokešová
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Corresponding author

Correspondence to L. Prokešová.

Additional information

1st part of this study:Pediatr.Allergy Immunol. 17, 175–183 (2006).

This work was supported by the grant no. IGA/MZ NR/8040-3 of theMinistry of Public Health of the Czech Republic.

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Žižka, J., Kverka, M., Novotná, O. et al. Perinatal period cytokines related to increased risk of future allergy development. Folia Microbiol 52, 549–555 (2007). https://doi.org/10.1007/BF02932118

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  • DOI: https://doi.org/10.1007/BF02932118

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