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The major histocompatibility complex and the neutral theory: The exception that proves the rule?

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References

  • Belich M. P., Madrigal J. A., Hildebrand W. H., Zemmour J, Williams R. C, Luz R., Petzl-Erler M. L. and Parham P. 1992 UnusualHLA-B alleles in two tribes of Brazilian Indians.Nature 357: 326–329

    Article  PubMed  CAS  Google Scholar 

  • Blagitko N., Figueroa F., O’hUigin C, Horai S., Watkins D. and Klein J. 1996 Polymorphism of theHLA-DRB1 locus in Columbian and Chilean Amerinds.Hum. Immunol. (submitted)

  • Butzer K. W., Isaac G. L., Richardson J. L and Washbourn-Kamau C. 1972 Radiocarbon dating of East African lake levels. New observations provide fresh insights into Lake Quaternary paleoclimates.Science 175: 1069–4076

    Article  PubMed  CAS  Google Scholar 

  • Clark A. G. and Kao T. 1991 Excess nonsynonymous substitution at shared polymorphic sites among self-incompatibility alleles of Solanaceae.Proc. Natl. Acad. Sci. USA 88: 9823–9827

    Article  PubMed  CAS  Google Scholar 

  • Coe M. J. 1966 The biology ofTilapia grahami Boulenger in Lake Magadi, Kenya.Ada Tropica 23:146–177

    Google Scholar 

  • Fan W., Kasahara I., Gutknecht J., Klein D., Mayer W. E., Jonker M. and Klein J. 1989 Shared class II Mhc polymorphisms between humans and chimpanzees.Hum. Immunol. 26:107–121

    Article  PubMed  CAS  Google Scholar 

  • Grahovac B., Sukernik R. I., Zaleska-Rutczynska Z., Blagitko N., Satta Y., Figueroa F. and Klein J. 1996 Polymorphism of theHLA-DRB1 locus in Siberian populations.Am. J. Hum. Genet, (submitted)

  • Graser R., O’hUigin C., Vineck V., Meyer A. and Klein J. 1996 Trans-species polymorphism of class IIMhc loci in danio fishes.Immunogenetics 44: 36–48

    Article  PubMed  CAS  Google Scholar 

  • Harris H. 1966 Enzyme polymorphism in man.Proc. R. Soc. London B164: 298–310

    Article  Google Scholar 

  • Hill A. V. S. 1991HLA associations with malaria in Africa: Some implications for MHC evolution. InMolecular evolution of the major histocompatibility complex (eds.) J. Klein and D. Klein (Heidelberg: Springer-Verlag) pp. 403–420

    Google Scholar 

  • Hill S. A., Allsopp C. E. M., Kwiatkowski D., Anstez N. M., Twumasi P., Rowe P. A., Bennett S., Brewster D., McMichael A. J. and Greenwood B. M. 1991 Common West African HLA antigens are associated with protection from severe malaria.Nature 352: 595–600

    Article  PubMed  CAS  Google Scholar 

  • Hughes A. L. and Nei M. 1988 Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection.Nature 353: 167–170

    Article  Google Scholar 

  • Kenter M., Otting N., Anholts J., Jonker M., Schipper R. and Bontrop R. E. 1992Mhc-DRB diversity of the chimpanzee.Immunogenetics 37: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Kimura M. 1968 Evolutionary rate at the molecular level.Nature 217: 624–626

    Article  PubMed  CAS  Google Scholar 

  • Kimura M. 1983The neutral theory of molecular evolution (Cambridge: Cambridge University Press)

    Google Scholar 

  • Klein D., Ono H, O’hUigin C., Vincek V., Goldschmidt T. and Klein J. 1993 Extensive MHC variability in cichlid fishes of Lake Malawi.Nature 364: 330–334

    Article  PubMed  CAS  Google Scholar 

  • Klein J. 1975 Many questions (and almost no answers) about the phylogenetic origin of the major histocompatibility complex.Adv. Exp. Med. Biol. 64: 467–478

    PubMed  CAS  Google Scholar 

  • Klein J. 1980 Generation of diversity at MHC loci: Implications for T-cell receptor repertoires. InImmunology 80 (eds.) M. Fougereau and J. Dausset (London: Academic Press) 239–253

    Google Scholar 

  • Klein J. 1986Natural history of the major histocompatibility complex (New York: Wiley)

    Google Scholar 

  • Klein J. 1987 Origin of major histocompatibility complex polymorphism: The trans-species hypothesis.Hum. Immunol. 19: 155–162

    Article  PubMed  CAS  Google Scholar 

  • Klein J. and Figueroa F. 1986 Evolution of the major histocompatibility complex.CRC Crit. Rev. Immunol. 6: 295–386

    CAS  Google Scholar 

  • Klein J. and O’hUigin C. 1995 Class II BMhc motifs in an evolutionary perspective.Immunol. Rev. 143: 89–111

    Article  PubMed  CAS  Google Scholar 

  • Klein J., Satta Y., O’hUigin C. and Takahata N. 1993a The molecular descent of the major histocompatibility complex.Annu. Rev. Immunol. 11: 269–295

    Article  PubMed  CAS  Google Scholar 

  • Klein J., Satta Y., Takahata N. and O’hUigin C. 1993b Trans-specific Mhc polymorphism and the origin of species in primates.J. Med. Primatol. 22: 57–64

    PubMed  CAS  Google Scholar 

  • Klitz W., Thomson G. and Baur M. P. 1986 Contrasting evolutionary histories among tightly linked HLA loci.Am. J. Hum. Genet. 39: 340–349

    PubMed  CAS  Google Scholar 

  • Lewontin R. C. and Hubby J. L. 1966 A molecular approach to the study of genic heterozygosity in natural populations, II. Amount of variation and degree of heterozygosity in natural populations ofDrosophila pseudoobscura.Genetics 54: 595–609

    PubMed  CAS  Google Scholar 

  • Lewontin R. C., Ginzburg L. R. and Tuljapurkar S. D. 1978 Heterosis is an explanation for large amounts of genie polymorphism.Genetics 88: 149–170

    PubMed  Google Scholar 

  • Nei M. 1987Molecular evolutionary genetics (New York: Columbia University Press)

    Google Scholar 

  • Nei M. and Graur D. 1984 Extent of protein polymorphism and the neutral mutation theory.Evol. Biol. 17: 73–118

    Google Scholar 

  • O’hUigin C. 1995 Quantifying the degree of convergence in primate Mhc-DRB genes.Immunol. Rev. 143:123–140

    Article  PubMed  CAS  Google Scholar 

  • Ono H., O’hUigin C., Tichy H. and Klein J. 1993 Major-histocompatibility-complex variation in two species of cichlid fishes from Lake Malawi.Mol. Biol. Evol. 10: 1060–1072

    PubMed  CAS  Google Scholar 

  • Pazderka F., Longenecker B. M., Law G. R. J., Stone H. A. and Ruth R. F. 1975 Histocompatibility of chicken populations selected for resistance to Marek’s disease.Immunogenetics 2: 93–100

    Article  Google Scholar 

  • Satta Y., Takahata N., Schonbach C., Gutknecht J. and Klein J. 1991 Calibrating evolutionary rates at major histocompatibility complex loci. InMolecular evolution of the major histocompatibility complex (eds.) J. Klein and D. Klein (Heidelberg: Springer-Verlag) pp. 51–62

    Google Scholar 

  • Satta Y., O’hUigin C., Takahata N. and Klein J. 1993 The synonymous substitution rate of the major histocompatibility complex loci in primates.Proc. Natl. Acad. Sci. USA 90: 7480–7484

    Article  PubMed  CAS  Google Scholar 

  • Satta Y., O’hUigin C., Takahata N. and Klein J. 1994 Intensity of natural selection at the major histocompatibility complex loci.Proc. Natl. Acad. Sci. USA 91: 7184–7188

    Article  PubMed  CAS  Google Scholar 

  • Takahata N. 1990 A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism.Proc. Natl Acad. Sci. USA 87: 2419–2423

    Article  PubMed  CAS  Google Scholar 

  • Takahata N., Satta Y. and Klein J. 1992 Polymorphism and balancing selection at major histocompatibility complex loci.Genetics 130: 925–938

    PubMed  CAS  Google Scholar 

  • Trewavas E. 1983Tilapiine fishes of the genera Sarotherodon, Oreochromis and Danakilia (London: British Museum (Nat. Hist.))

    Google Scholar 

  • Vincek V., O’hUigin C., Satta Y., Boag P., Grant P. R., Grant B. R. and Klein J. 1996 How large was the founding population of Darwin’s finches?Proc. R. Soc. London (submitted)

  • Watkins D. I., McAdam S. N., Liu X., Strang C. R., Milford E. L., Levine C. G., Garber T. L., Dogon A. L., Lord C. I., Ghim S. H., Troup G. M., Hughes A. L. and Letvin N. L. 1992 New recombinant HLA-B alleles in a tribe of South Amerindians indicate rapid evolution of MHC class I loci.Nature 357:329–333

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institute for Biology, Abteilung Immungenetik, Corrensstrasse 42, D-72076, Tubingen, Germany

    Jan Klein

  2. Department of Microbiology and Immunology, University of Miami School of Medicine, 33136, Miami, FL, USA

    Jan Klein

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Klein, J. The major histocompatibility complex and the neutral theory: The exception that proves the rule?. J. Genet. 75, 117–124 (1996). https://doi.org/10.1007/BF02931755

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