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Prevention of infection transmission during stem cell transplantation

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Abstract

Group of 152 patients (investigated before autologous transplantation) and 35 healthy donors for allogeneic transplantation was examined for the risk of infection transmission that can be associated with the infusion of cryopreserved peripheral blood progenitor cells to the patient and/or cross-contamination of stored grafts. No laboratory signs of active infection were found in 22 donors (63 %) and in 91 patients (60%). The most common was active infection by herpes viruses — 50 cases in patients, 21 cases in donors; hepatitis B was found in only two cases. The rate of clinically unsuspected (but dangerous) infections in donors and patients thus remains relatively high in spite of the fact that the system of donor search and the whole transplantation procedure have improved in the last years. The system of safety assurance is extremely important and the whole palette of preventive tests according to EBMT (European Blood and Marrow Transplantation Group) and ISHAGE (International Society for Hemotherapy and Graft Engineering) is fully justified.

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Abbreviations

AU:

arbitrary unit

EIA:

enzyme immunoassay method

EBMT:

European Blood and Marrow Transplantation Group

HR:

International Institute of Refrigeration

ISHAGE:

International Society for Hemotherapy and Graft Engineering

CMV:

cytomegalovirus

EBV:

Epstein-Barr virus

HAV:

hepatitis A virus

HIV:

human immunodeficiency virus

G-CSF:

granulocyte colony-stimulating factor

SCT:

stem cell transplantation(s)

HSV:

herpes simplex virus

HTLV:

human T-cell lymphotropic virus

VZV:

varicella-zoster virus

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Authors and Affiliations

  1. University Hospital, Medical Faculty, Charles University, 500 05, Hradec Králové, Czechia

    M. Bláha, P. Měřička, V. Štěpánová, M. Špliňo, J. Malý, L. Jebavý, P. Žák, M. Cermanová, S. Filip, M. Blažek & V. Řeháček

Authors
  1. M. Bláha
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  2. P. Měřička
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  3. V. Štěpánová
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  4. M. Špliňo
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  5. J. Malý
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  6. L. Jebavý
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  7. P. Žák
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  8. M. Cermanová
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  9. S. Filip
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  10. M. Blažek
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  11. V. Řeháček
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Additional information

This work was supported by grant MZ0 0017 9906 of theMinistry of Health of the Czech Republic.

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Bláha, M., Měřička, P., Štěpánová, V. et al. Prevention of infection transmission during stem cell transplantation. Folia Microbiol 51, 609–613 (2006). https://doi.org/10.1007/BF02931627

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  • DOI: https://doi.org/10.1007/BF02931627

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