Abstract
Some patients with immunodeficiency develop clinical features of autoimmune disorders. A previously asymptomatic antibody deficiency can underlie the development of autoimmune diseases and a severe course of infection, with a risk of sepsis; such cases are known in selective IgA deficiency. On the other hand, little information is available on selective IgG subclass deficiencies. An unexpectedly severe course ofCampylobacter infection in a 19-year-old woman with a previously undiagnosed complex immune disorder, including selective IgG1 immunodeficiency, Hashimoto’s autoimmune thyroiditis with hypothyroidism combined with Addison’s disease presumably due to autoimmune adrenalitis, autoimmunity and allergy is described. The pathophysiological mechanisms of autoimmunity in latent humoral defects are discussed.
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This study was supported by Research Project no. MZO 0017 9906 of theMinistry of Health of the Czech Republic.
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Kopecký, O., Lukešová, Š., Horáček, J. et al. Campylobacter sepsis with multiple organ failure in IgG subclass deficiency. Folia Microbiol 51, 604–608 (2006). https://doi.org/10.1007/BF02931626
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DOI: https://doi.org/10.1007/BF02931626