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Antimicrobial activity of some 2- and 3-pyridinyl-1H-benzimidazoles and their FeIII, CuII, ZnII, and AgI complexes

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Abstract

2-(2-Pyridinyl)-(L I), 2-(6-methyl-2-pyridinyl)-(L II), 2-(6-methyl-2-pyridinyl)-5-methyl-(L III), 2-(3-pyridinyl)- (L IV), 2-(3-pyridinyl)-5-methyl-1H-benzimidazoles (L V) and their complexes with Fe(NO3)3, Cu(NO3)2, Zn(NO3)2, and AgNO3 were synthesized and antibacterial activity of the compounds was tested towardStaphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity againstCandida albicans. The methyl groups ofL III increase the antimicrobial activity. The AgI complexes have considerable activity toward the microorganisms. Some ZnII complexes show an antimicrobial effect againstS. aureus andS. flexneri, although the ligands themselves have no effect. CuII complexes have a considerable antibacterial effect toS. aureus andS. epidermidis.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Engineering, Istanbul University, 34850, Avcilar, Istanbul, Turkey

    A. Tavman & B. Ülküseven

  2. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116, Beyazit, Istanbul, Turkey

    S. Birteksöz & G. Ötük

Authors
  1. A. Tavman
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  2. B. Ülküseven
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  3. S. Birteksöz
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  4. G. Ötük
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Additional information

This work was supported by the Research Fund ofThe University of Istanbul, project no. 1087/010598.

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Tavman, A., Ülküseven, B., Birteksöz, S. et al. Antimicrobial activity of some 2- and 3-pyridinyl-1H-benzimidazoles and their FeIII, CuII, ZnII, and AgI complexes. Folia Microbiol 48, 479–483 (2003). https://doi.org/10.1007/BF02931328

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  • DOI: https://doi.org/10.1007/BF02931328

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