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The effect of bilirubin on the fc receptor expression and phagocytic activity of mouse peritoneal macrophages

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Abstract

The effect of bilirubin on the phagocytic activity of mouse peritoneal macrophages and on the expression of Fc receptors and receptors for SRBC was studied. Intraperitoneally administered bilirubin influenced the expression of Fc receptors for IgM, IgG2B, IgA and IgE, whereas the expression of other receptors as well as the phagocytic activity of peritoneal macrophages remained unchanged. The possible mechanism of the effect of bilirubin on Fc receptors is discussed.

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Abbreviations

ADCC:

antibody-dependent cell cytotoxicity

FcR:

receptor for the Fc fragment of an immunoglobulin

PBS:

phosphate-buffered saline

PHA:

phytohemagglutinin

SRBC:

sheep red blood cells

TNP:

2,4,6-trinitrophenyl

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Authors and Affiliations

  1. Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20, Prague 4

    V. Větvička, I. Miler, P. Šíma, L. Táborský & L. Fornůsbk

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  1. V. Větvička
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  2. I. Miler
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  3. P. Šíma
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  4. L. Táborský
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  5. L. Fornůsbk
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Větvička, V., Miler, I., Šíma, P. et al. The effect of bilirubin on the fc receptor expression and phagocytic activity of mouse peritoneal macrophages. Folia Microbiol 30, 373–380 (1985). https://doi.org/10.1007/BF02927593

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  • DOI: https://doi.org/10.1007/BF02927593

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