Skip to main content
Log in

Látky stimulující biosyntesu chlortetracyklinu u nízkoprodukčního kmenestreptomyces aureofaciens

Вещества, стимулирование биосинтеза хлортетрациклинав с низким уровнем производства штамма streptomyces aureofaciens

Substances stimulating the biosynthesis of chlortetracycline in a low-production strain ofstreptomyces aureofaciens

  • Published:
Folia Microbiologica Aims and scope Submit manuscript

Резюме

С большой выбор из 32 соединений, 13 были найдены иметь благоприятный эффект в увеличении производства от хлортетрациклина. Из них, β-indolylacetic кислота, phenylacetic кислотα,-нафтил-acetie кислота п-chlorphenoxyacetic кислота, α-naphthylamine β-naphthylamme p-aminobenzoic кислота, кислота quinic, phloroglucinol, галльской кислоты и m-инозитол увеличения урожайности в низкие производственные штамма Streptomyces aureofaciens более чем на 100%, используя Duggar брожения среды.

Summary

From a wide selection of 32 compounds, 13 were found to have a favourable effect in increasing production of chlortetracycline. Of these, β-indolylacetic acid, phenylacetic acid, a-naphthyl-acetie acid, p-chlorphenoxyacetic acid, α-naphthylamine, β-naphthylamme, p-aminobenzoic acid, quinic acid, phloroglucinol, gallic acid and m-inositol increased yield in a low production strain of Streptomyces aureofaciens by more than 100%, using a Duggar fermentation medium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatura

  • Baron, A. L.:Handbook of antibiotics. New York 1950.

  • Fruton, J. S., Simmonds, S.:General biochemistry. New York 1953.

  • Gordon, M., Haskins, F. A., Mitchell, H. K.:The growth-promoting properties of quinic acid. Proc. Nati. Acad. Sci. U. S. 36: 427, 1950.

    Article  CAS  Google Scholar 

  • Gottlieb, D., Carter, H. E., Legator, M., Gallicchio, V.:The biosynthesis of chloramphenicol. I. Precursors stimulating the synthesis. J. Bact. 68: 243, 1954.

    PubMed  CAS  Google Scholar 

  • Gourévitch, A., Lein, J.:Tetracycline and substitued tetracyclines. C. A. 49: 14278d, 1955.

    Google Scholar 

  • Hutehings, B. L., Waller, W., Gordon, S., Broschard, R. W., Wolf, F., Goldman, A. A., Wiliams, J. H.:Degradation of aureomycin. J. Am. Chem. Soc. 74: 3710, 1952a.

    Article  Google Scholar 

  • Hutchings, B. L., Waller, W., Broschard, R. W., Wolf, C. F., Fryth, P. W., Williams, J. H.:V. Degradation of aureomycin. Aureomycinic acid. J. Am. Chem. Soc. 74: 4980, 1952b.

    Article  CAS  Google Scholar 

  • Kuhn, R., Dury, K.:Alkalischer Abbau von Aureomycin und Terramycin. Chem. Berichte 84: 563, 1951.

    Article  CAS  Google Scholar 

  • Kursanov, A. L.:Sintez i prevraščenija dubilnych veščestv v čajnom rasteniji. Moskva 1952.

  • Miller, P. A., McCormick, J. R. D., Doerschuk, A. P.:Studies of chlortetracycline biosynthesis and the preparation of chlortetracycline-C 14. Science 123: 3206, 1956.

    Google Scholar 

  • Mitsuhashi, S., Davis, B. D.:Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase. Biochim. Biophys. Acta 15: 268, 1954.

    Article  PubMed  CAS  Google Scholar 

  • Snell, E. E.:Growth promotion on tryptophan-deficient media by o-aminobenzoic acid and its attempted reversal with orthanilamide. Arch. Biochem. 2: 389, 1943.

    CAS  Google Scholar 

  • Waller, W., Hutchings, B. L., Wolf, C. F., Broschard, R. W., Goldman, A. A., Williams, J. H.:Degradation of aureomycin. III. 3,4-dihydroxy-2,5-dioxocyclopentane-1-carboxamide. J. Am. Chem. Soc. 74: 4978, 1952a.

    Article  CAS  Google Scholar 

  • Waller, C. W., Hutchings, B. L., Wolf, C. F., Broschard, R. W., Goldman, A. A., Williams, J. H.:Degradation of aureomycin. IV. Desdimethylaminoaureomycinic acid. J. Am. Chem. Soc. 74: 4978, 1952b.

    Article  CAS  Google Scholar 

  • Waller, W., Hutchings, B. L., Wolf, F., Goldman, A. A., Broschard, R. W., Williams, J. H.:Degradation of aureomycin. VI. Isoaureomycin and aureomycin. J. Am. Chem. Soc. 74: 4981, 1952c.

    Google Scholar 

  • Waller, C. W., Hutchings, B. L., Broschard, R. W., Goldman, A. A., Stein, W. J., Wolf, F., Williams, J. H.:Degradation of aureomycin. VII. Aureomycin and anhydroaureomycin. J. Am. Chem. Soc. 74: 4981, 1952d.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vaněk, Z. Látky stimulující biosyntesu chlortetracyklinu u nízkoprodukčního kmenestreptomyces aureofaciens . Folia Microbiol 2, 275–281 (1957). https://doi.org/10.1007/BF02927463

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02927463

Navigation