Abstract
Using the migration of human polymorphonuclear leukocytes in agarosein vitro, it was established that bilirubin inhibits migration (chemotaxis) of these cells upon stimulation with both complement-derived (zymosan-activated serum) and bacteria-derived (abacterial filtrate ofE. coli) chemotactic agents.
Similar content being viewed by others
References
Ansaldi N., Fiandino G., Ciriotti G.: Changes in the imunoglobulin level in hyperbilirubinaemic premature infants.Minerva Paediat. 20, 1982 (1968).
Becker E.L.: Stimulated neutrophil locomotion.Arch.Pathol.Lab.Med. 101, 509 (1977).
Cowger M.L., Mustafa M.G.: Some membrane effects of bilirubin (Abstract).Pediat.Res. 5, 419 (1971).
De Ritis F., Paeadisi F., Maio G.: The effect of unconjugated bilirubin and some bilirubin precursors on cell culture.Path.Microbiol. 37, 37 (1971).
De Sanctis C, Malandra C, Zanetti P., Fabris C, Ponzone A.: Neonatal hyperbilirubinaemia and response of lymphocytes to phytohaemagglutinin.Minerva Paediat. 20, 2011 (1968).
Diazdel CastilloE.: Neonatal hyperbilirubinaemia. Its relation to the immunological response capacity of the newborn infants.Gac.Med.Mex. 105, 185 (1973).
Maisels M. J.: Bilirubin. On understanding and influencing its metabolism in the newborn infant.Ped.Clin. N.Amer. 19, 447 (1972).
Miler I., Vondráček J., Hromádková L.: The bactericidal activity of sera of healthy neonates and of newborns with hyperbilirubinaemia toEscherickia coli.Folia Microbiol. 24, 143 (1979).
Nejedlá Z.: The development of immunological factors in infants with hyperbilirubinaemia.Pediatrics 45, 102 (1970).
Nelson R.D., Quie P.G., Simmons R.L.: Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.J.Immunol. 115, 1650 (1975).
Rola-Plesczynski M., Hensen S.A., Vincent M.M., Bellanti J.A.: Inhibitory effects of bilirubin on cellular immune responses of man.J.Pediat. 86, 690 (1975).
Rubaltelli F.F., Piovesan A.L., Semenzato C., Barbato A., Ongabo G.: Immune competence assessment in hyperbilirubinaemic newborns before and after phototherapy.Helv.Paediat.Acta 32, 129 (1977).
Schenker S., Mc Candless D.W., Zollman P.E.: Studies of cellular toxicity of unconjugated bilirubin in kernicterus brain.J.Clin.Invest. 45, 1213 (1966).
Thong Y.H., Rencis V.: Bilirubin inhibits hexose-monophosphate shunt activity of phagocytosing neutrophils.Acta Paediat.Scand. 66, 757 (1977).
Thong Y.H., Ness D., Ferrante A.: Effect of bilirubin on the fungicidal capacity of human neutrophils.Sabouraudia 17, 125 (1979).
Xanthou M., Mandyla-Sfagou E., Campbell A.C., Waller C.A., Economott-Mavrott C, Matsaniotis N.: Lymphocyte subpopulations and their function in the blood of neonates, p. 139 inIntensive Care in the Newborn. Masson Publ. Inc., New York 1976.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Miler, I., Vondeáček, J. & Hromádková, L. Bilirubin inhibits the chemotactic activity of human polymorphonuclear leukocytesin vitro . Folia Microbiol 26, 413–416 (1981). https://doi.org/10.1007/BF02927337
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02927337