Abstract
The production isolation and purification of a yellow mycotoxin fromPenicillium citreoviride NRRL 2579 in different culture media was described. When injected subcutaneously to albino rats it alters the kinetic pattern of transketolase (EC 2.2.1.1) in liver in vivo in a competitive manner. In vitro, the inhibition is noncompetitive in nature. However, addition of thiamine diphosphate (TPP) to the m vitro system relieved the inhibitory effect. These findings suggested a relationship between citreoviridininduced beriberi and the probable antithiamine effect of the toxin.
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Part of this paper was presented at the 47th Annual Conference of the Society of Biological Chemists (India) held at Delhi, October 1978.
We thank Dr. J.V. Rodricks, Chief, Biochemistry Division, Food and Drug Administration, Washington D.C. USA for the gift of standard citreoviridin for comparison with our prepared toxin. The authors are thankful to Calcutta University for the financial assistance enjoyed during this investigation.
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Datta, S.C., Ghosh, J.J. Production and purification ofPenicillium citreoviride toxin and its effect on tpp-dependent liver transketolase. Folia Microbiol 26, 408–412 (1981). https://doi.org/10.1007/BF02927336
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DOI: https://doi.org/10.1007/BF02927336