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Structural changes of the exocrine pancreas in a patient with cholecystolithiasis

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Summary

The exocrine pancreas has been studied histologically, morphometrically, and ultrastructurally in a patient with choiecystolithiasis in comparison with three control patients free from gastrointestinal or pancreatic diseases. In the gallstone-bearing patient, acinar cells undergo a significant increase in the average cell area and average zymogenic area (i.e., the portion of acinar cell cytoplasm occupied by zymogen granules). In addition, these cells showed cytological signs of enhanced synthesis of secretory proteins and increased formation and release of zymogen granules. The findings concerning centroacinar/ductular cells are consistent with a significant increase in their number and average cell area that is associated with ultrastructural signs of enhanced functional activity.

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References

  1. Kataoka S, Syoji K. Elevated cholecystokinin-like activity in the duodenal mucosa in patients with cholecystolithiasis.Tohoku J Exp Med 1985; 145: 395–402.

    Article  PubMed  CAS  Google Scholar 

  2. Upp JR, Nealon WH, Singh P, Fagan CJ, Jonas AS, Greeley GH, Thompson JC. Correlation of cholecystokinin receptors with gallbladder contractility in patients with gallstones.Ann Surg 1987; 205: 641–648.

    Article  PubMed  Google Scholar 

  3. Albores-Saavedra J, Nadji M, Henson DE, Ziegels-Weissman J, Mones JM. Intestinal metaplasia of the gallbladder: a morphologic and immunocytochemical study.Hum Pathol 1986; 17: 614–620.

    Article  PubMed  CAS  Google Scholar 

  4. Tsutsumi Y, Nagura H, Osamura RY, Watanabe K, Yanaihara N. Histochemical studies of metaplastic lesions in the human gallbladder.Arch Pathol Lab Med 1984; 108: 917–921.

    PubMed  CAS  Google Scholar 

  5. Dockray GJ, Gregory, RA. Gastrin.Handbook ofPhysiology: The Gastrointestinal System, vol. 2. Schultz SG, Makhlouf GM, Rauner BB, eds., Oxford UniversityPress, New York, 1989; 311–336.

    Google Scholar 

  6. Rehfeld JF. Cholecystokinin.Handbook of Physiology:The Gastrointestinal System, vol. 2, Schultz SG, Makhlouf GM, Rauner BB, eds. Oxford University Press, New York, 1989; 337–358.

    Google Scholar 

  7. Lee KT, Ching Sheen P. Effects of gallstones on pancreaticacinar cells. An ultrastructural study.Eur Surg Res 1988; 20: 341–351.

    Article  PubMed  CAS  Google Scholar 

  8. Riva A. A simple and rapid staining method for enhancingthe contrast of tissues previously treated with uranylacetate.J Microscopie 1974; 19: 105–108.

    CAS  Google Scholar 

  9. Bani D, Magnani L, Bani Sacchi T, Biliotti G. Theexocrine pancreas in patients with hyperinsulinemichypoglycemia.Int J Pancreatol 1989; 5: 239–248.

    PubMed  CAS  Google Scholar 

  10. Ghadially FN.Ultrastructural Pathology of the Cell: A Textand Atlas of Physiological and Pathological Alterations inCell Fine Structure, Butterworth, London, 1975; 80–83.

    Google Scholar 

  11. Buanes T, Grotmol T, Landsverk T, Nafstad P, Raeder MG. Effects of arterial pH and carbon dioxide onpancreatic exocrine H+ HCO3 secretion and secretin-dependent translocation of cytoplasmic vesicles inpancreatic duct cells.Acta Physiol Scand 1988; 133: 1–9.

    Article  PubMed  CAS  Google Scholar 

  12. Stace NH, Palmer TJ, Vaja S, Dowling RH. Longtermpancreatico-biliary diversion stimulates hyperplastic andadenomatous nodules in the rat pancreas: a new modelfor spontaneous tumor formation.Gut 1987; 28 (Suppl.1): 265–268.

    Article  PubMed  Google Scholar 

  13. Howatson AG, Carter DC. Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model.Br J Cancer 1985; 51: 107–114.

    PubMed  CAS  Google Scholar 

  14. Lhoste EF, Longnecker DS. Effect of bombesin andcaerulein on early stages of carcinogenesis induced byazaserine in the rat pancreas.Cancer Res 1987; 47: 3273–3277.

    PubMed  CAS  Google Scholar 

  15. Konishi Y, Denda A, Inui S, Takahashi S, Kondo H. Pancreatic carcinoma induced by 4-hydroxyamino-quinoline 1-oxide after partial pancreatectomy andsplenectomy in rats.Gann 1976; 67: 919,920.

    PubMed  CAS  Google Scholar 

  16. Konishi Y, Denda A, Miyata Y, Kawabata H. Enhance-ment of pancreatic tumorigenesis of 4-hydroxyamino-quinoline 1-oxide by ethionine in rats.Gann 1976; 67: 91–95.

    PubMed  CAS  Google Scholar 

  17. Denda A, Inui S, Sunagawa M, Takahashi S, Konishi Y. Enhancing effect of partial pancreatectomy and ethionine-induced pancreatic regeneration on the tumorigenesis ofazaserine in rats.Gann 1978; 69: 633–639.

    PubMed  CAS  Google Scholar 

  18. Levison DA, Morgan RG, Brimacombe JS, Hopwood D, Coghill G, Wormsley KG. Carcinogenic effect of di(2-hydroxypropyl)nitrosamine (DHPN) in male Wistar rats:promotion of pancreatic cancer by a raw soya flour diet.Scand J Gastroenterol 1979; 14: 217–224.

    Article  PubMed  CAS  Google Scholar 

  19. Sommers SC, Murphy SA, Warren S. Pancreatic ducthyperplasia and cancer.Gastroenterology 1954; 27: 629–640.

    PubMed  CAS  Google Scholar 

  20. Konishi Y, Mizumoto K, Kitazawa S, Tsujiuchi T, Tsutsumi M, Kamano T. Early ductal lesions of pancreaticcarcino-genesis in animals and humans.Int J Pancreatol 1990; 7: 83–89.

    Article  PubMed  CAS  Google Scholar 

  21. Norell S, Halbom A, Erwald R, Jacobson G, Lindberg-Navier I, Olin R, Wiechel KL. Diabetes, gall stone disease,and pancreatic cancer (letter to the editor).Br J Cancer 1986; 54: 377–378.

    PubMed  CAS  Google Scholar 

  22. Kuzick J, Babiker AG. Pancreatic cancer, alcohol, diabetesmellitus and gall-bladder disease.Int J Cancer 1989; 43: 415–421.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Human Anatomy and Histology-Section of Histology, University of Florence, Florence, Italy

    Leonardo Magnani, Daniele Bani & Tatiana Bani Sacchi

  2. Department of Physiopathology-Section of Surgery, University of Florence, Florence, Italy

    Giancarlo Biliotti

Authors
  1. Leonardo Magnani
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  2. Daniele Bani
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  3. Giancarlo Biliotti
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  4. Tatiana Bani Sacchi
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Magnani, L., Bani, D., Biliotti, G. et al. Structural changes of the exocrine pancreas in a patient with cholecystolithiasis. Int J Pancreatol 12, 53–59 (1992). https://doi.org/10.1007/BF02927070

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  • DOI: https://doi.org/10.1007/BF02927070

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