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Effect of cyclophosphamide on the candidacidal activity of rabbit peritoneal macrophages

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Abstract

Single and repeated intravenous administration of cyclophosphamide significantly decreased the candidacidal activity of rabbit peritoneal macrophages. Using higher doses of the drug, a more pronounced decrease, persisting up to 10 d, was observed. The phagoeytic index has not changed significantly 10 d after cyclophosphamide injection as compared with controls. No changes in the phagocytic activity were recorded. The decreased candidacidal activity may be one of the causes of serious microbial infections in cyclophosphamide-treated patients.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Medical Faculty, Comenius University, 81108, Bratislava, Czechoslovakia

    D. Kotulová, M. Žalkovičová & J. Štefanovič

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  1. D. Kotulová
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  2. M. Žalkovičová
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  3. J. Štefanovič
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Kotulová, D., Žalkovičová, M. & Štefanovič, J. Effect of cyclophosphamide on the candidacidal activity of rabbit peritoneal macrophages. Folia Microbiol 33, 401–406 (1988). https://doi.org/10.1007/BF02925851

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  • DOI: https://doi.org/10.1007/BF02925851

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