Abstract
Variants resistant to propionate wore prepared from a mutant strain ofStreptomyces cinnamonensis producing predominantly monensin A. Using selected resistants the production of monensins (in media with higher concentrations of propionate) was examined. Stimulation of monensin synthesis by propionate. was observed with 70% of the resistants studied. Propionate did not influence the ratio between monensin A and B production.
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Agtarap A., Chamberlin J.W.: Monensin, a new biologically active compound. TV. Chemistry.Antimicrob. Agents Chemother. 1967, 359–362 (1968).
Ajaz A.A., Robinson J.A., Turner D.L.: Biosynthesis of the polyether ionophore antibiotic monensin A: Assignment of the carbon-13 and proton N.M.R. spectra of monensin A by two-dimensional spectroscopy. Incorporation of oxygen-18 labelled molecular oxygen.J. Chem. Soc. Perkin Trans. 1, 27–36 (1987).
Beran M., Zima J., Schön V.: Determination of sodium salts of monensin A and B in the premix and fermentation broth by electron impact mass spectrometry.Biomed. Environment. Mass Spectrom. 14, 153–156 (1987).
Blumauerová M., Matějů J., Stajner K., Vaněk Z.: Studies on the production of daunomy-cinone-derived glycosides and related metabolites inStreptomyces coeruleorubidus andStreplomyces peucetius.Folia Microbiol. 22, 275–285 (1977).
Cane D.E., Liang T.-C., Hasler H.: Polyether biosynthesis. Origin of the oxygen atoms of monensin A.J. Amer. Chem. Soc. 103, 5962–5965 (1981).
Cane D.E., Liang T.-C, Hasler H.: Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A.J. Amer. Chem. Soc. 104, 7274–7281 (1982).
Day L.E., Chamberlin J.W., Gordee E.Z., Chen S., Gorman M., Hamill R.L., Ness T., Weeks R.E., Stroshane R.: Biosynthesis of monensin.Antimicrob. Agenta Chemother. 4, 410–414 (1973).
Gorman M., Chamberlin J.W., Hamill R.L.: Monensin, a new biologically active compound. V. Compou1nds related to monensin.Antimicrob. Agents Chernother. 1967, 363–368 (1968).
Hanby M.E., Hoehn M.M.: Monensin, a new biologically active compound. I. Discovery and isolation.Antimicrob. Agents Chemother. 1967, 349–352 (1968).
Hesseltine C.W., Benedict R.G., Pridham F.G.: Useful criteria for species differentiation in the genusStreptomyces.Ann. N.Y. Acad.Sci. 60, 136–151 (1954).
Královcová E., Krumphanzl V., Vaněk Z.: Improving the production of monensin byStreptomyces cinnamonensis.Folia Microbiol. 29, 35–42 (1984).
Liu C.: Microbial aspects of polyether antibiotics: Activity, production, and biosynthesis, p. 43–102 in Westley J. W. (Ed.):Polyether Antibiotics, Vol. 1. Marcel Dekker, New York-Basel 1982.
Lutz W.K., Winkler F.K., Dunitz J.D.: Crystal structure of the antibiotic monensin. Similarities and differences between the free acid and metal complex.Helv. Chim. Acta 54, 1103–1108 (1971).
Matějů J., Blumauerová M., Vaněk Z.: Biogenesis of substances of the daunomycin type byStreptomyces coeruleorubidus 39-146.Folia Microbiol. 22, 470 (1977).
Paranosenkova V.I., Karpov V.L.: The study of rubomycin biosynthesis.Bioorg. Khim. 1, 1755–1759 (1975).
Pinkerton M., Steinrauf L.K.: Molecular structure of monovalent metal cation complexes of monensin.J. Mol. Biol. 49, 533–546 (1970).
Pospíšil S., Cimburková E., Krumphanzl V., Vaněk Z.: Effect of precursors on biosynthesis of monensins A and B.Folia Microbiol. 30, 30–33 (1985).
Pospíšil S., Královcová E., Stajner K., Tax J., Krumphanzl V., Vaněk Z.: Regulation of biosynthesis of monensins on the chemically defined medium.Folia Microbiol. 27, 275–277 (1982).
Pospíšil S., Peterková M., Krumphanzl V., Vaněk Z.: Regulatory mutants ofStreptomyces cinnamonensis producing monensin A.FEMS Microbiol. Lett. 24, 209–213 (1984).
Pospíšil S., Sedmera P., Havránek M., Krumphanzl V., Vaněk Z.: Biosynthesis of monensins A and B.J. Antibiot. 36, 617–619 (1983).
Pospíšil S., Sedmera P., Krumphanzl V., Vaněk Z.: Biosynthesis of monensins A and B: the role of isoleucine.Folia Microbiol. 31, 8–14 (1986).
Pressman B.C.: Biological applications of ionophores.Ann. Rev. Biochem. 45, 501–530 (1976).
Sherman M.M., Hutchinson C.R.: Biosynthesis of lasalocid A. Biochemical alteration of polyether antibiotic production.J. Antibiot. 39, 1270–1280 (1986).
Sherman M.M., Yue S., Hutchinson C.R.: Biosynthesis of lasalocid A. Metabolic interrelationships of carboxylie acid precursors and polyether antibiotics.J. Antibiot. 39, 1135–1143 (1986).
Shumard R.F., Callender M.E.: Monensin, a new biologically active compounds. VI. Anticoccidical activity.Antimicrob. Agents Chemother. 1967, 369–377 (1968).
Sood G.R., Robinson J.A., Ajaz A.A.: Biosynthesis of the polyether antibiotic monensin-A. Incorporation of [2-2H2]-(R)-[2-2H1]-and(S)-[2-2H1]-propionate.J. Chem. Soc. Chem. Commun. 1421–1423 (1984).
Vaněk Z., Pospíšil S., Tax J., Klánová K., Cimburková E., Tichý P., Voříšek J., Cudlín J., Krumphanzl V.: Biogenesis of oligoketides, p. 213–219 in Umezawa H., Demain A. L., Hata T., Hutchinson R. C. (Eds.):Trends in Antibiotic Research. Japan Antibiotic Research Association, Tokyo 1982.
Westley J.W.: Polyether antibiotics: Versatile carboxylie acid ionophores produced byStreptomyces.Adv. Appl. Microbiol. 22, 177–223 (1977).
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The authors wish to thank Dr. M. Beran for the measurement of mass spectra and Dr. S. Pospíšil who kindly provided the parent strain of this study.
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Matějů, J., Karnetová, J., Nohýnek, M. et al. Propionate and the production of monensins inStreptomyces cinnamonensis . Folia Microbiol 33, 440–446 (1988). https://doi.org/10.1007/BF02925768
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DOI: https://doi.org/10.1007/BF02925768