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Propionate and the production of monensins inStreptomyces cinnamonensis

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Abstract

Variants resistant to propionate wore prepared from a mutant strain ofStreptomyces cinnamonensis producing predominantly monensin A. Using selected resistants the production of monensins (in media with higher concentrations of propionate) was examined. Stimulation of monensin synthesis by propionate. was observed with 70% of the resistants studied. Propionate did not influence the ratio between monensin A and B production.

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References

  • Agtarap A., Chamberlin J.W.: Monensin, a new biologically active compound. TV. Chemistry.Antimicrob. Agents Chemother. 1967, 359–362 (1968).

    Google Scholar 

  • Ajaz A.A., Robinson J.A., Turner D.L.: Biosynthesis of the polyether ionophore antibiotic monensin A: Assignment of the carbon-13 and proton N.M.R. spectra of monensin A by two-dimensional spectroscopy. Incorporation of oxygen-18 labelled molecular oxygen.J. Chem. Soc. Perkin Trans. 1, 27–36 (1987).

    Article  Google Scholar 

  • Beran M., Zima J., Schön V.: Determination of sodium salts of monensin A and B in the premix and fermentation broth by electron impact mass spectrometry.Biomed. Environment. Mass Spectrom. 14, 153–156 (1987).

    Google Scholar 

  • Blumauerová M., Matějů J., Stajner K., Vaněk Z.: Studies on the production of daunomy-cinone-derived glycosides and related metabolites inStreptomyces coeruleorubidus andStreplomyces peucetius.Folia Microbiol. 22, 275–285 (1977).

    Article  Google Scholar 

  • Cane D.E., Liang T.-C., Hasler H.: Polyether biosynthesis. Origin of the oxygen atoms of monensin A.J. Amer. Chem. Soc. 103, 5962–5965 (1981).

    Article  CAS  Google Scholar 

  • Cane D.E., Liang T.-C, Hasler H.: Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A.J. Amer. Chem. Soc. 104, 7274–7281 (1982).

    Article  CAS  Google Scholar 

  • Day L.E., Chamberlin J.W., Gordee E.Z., Chen S., Gorman M., Hamill R.L., Ness T., Weeks R.E., Stroshane R.: Biosynthesis of monensin.Antimicrob. Agenta Chemother. 4, 410–414 (1973).

    CAS  Google Scholar 

  • Gorman M., Chamberlin J.W., Hamill R.L.: Monensin, a new biologically active compound. V. Compou1nds related to monensin.Antimicrob. Agents Chernother. 1967, 363–368 (1968).

    Google Scholar 

  • Hanby M.E., Hoehn M.M.: Monensin, a new biologically active compound. I. Discovery and isolation.Antimicrob. Agents Chemother. 1967, 349–352 (1968).

    Google Scholar 

  • Hesseltine C.W., Benedict R.G., Pridham F.G.: Useful criteria for species differentiation in the genusStreptomyces.Ann. N.Y. Acad.Sci. 60, 136–151 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Královcová E., Krumphanzl V., Vaněk Z.: Improving the production of monensin byStreptomyces cinnamonensis.Folia Microbiol. 29, 35–42 (1984).

    Article  Google Scholar 

  • Liu C.: Microbial aspects of polyether antibiotics: Activity, production, and biosynthesis, p. 43–102 in Westley J. W. (Ed.):Polyether Antibiotics, Vol. 1. Marcel Dekker, New York-Basel 1982.

    Google Scholar 

  • Lutz W.K., Winkler F.K., Dunitz J.D.: Crystal structure of the antibiotic monensin. Similarities and differences between the free acid and metal complex.Helv. Chim. Acta 54, 1103–1108 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Matějů J., Blumauerová M., Vaněk Z.: Biogenesis of substances of the daunomycin type byStreptomyces coeruleorubidus 39-146.Folia Microbiol. 22, 470 (1977).

    Google Scholar 

  • Paranosenkova V.I., Karpov V.L.: The study of rubomycin biosynthesis.Bioorg. Khim. 1, 1755–1759 (1975).

    CAS  Google Scholar 

  • Pinkerton M., Steinrauf L.K.: Molecular structure of monovalent metal cation complexes of monensin.J. Mol. Biol. 49, 533–546 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Pospíšil S., Cimburková E., Krumphanzl V., Vaněk Z.: Effect of precursors on biosynthesis of monensins A and B.Folia Microbiol. 30, 30–33 (1985).

    Article  Google Scholar 

  • Pospíšil S., Královcová E., Stajner K., Tax J., Krumphanzl V., Vaněk Z.: Regulation of biosynthesis of monensins on the chemically defined medium.Folia Microbiol. 27, 275–277 (1982).

    Article  Google Scholar 

  • Pospíšil S., Peterková M., Krumphanzl V., Vaněk Z.: Regulatory mutants ofStreptomyces cinnamonensis producing monensin A.FEMS Microbiol. Lett. 24, 209–213 (1984).

    Google Scholar 

  • Pospíšil S., Sedmera P., Havránek M., Krumphanzl V., Vaněk Z.: Biosynthesis of monensins A and B.J. Antibiot. 36, 617–619 (1983).

    PubMed  Google Scholar 

  • Pospíšil S., Sedmera P., Krumphanzl V., Vaněk Z.: Biosynthesis of monensins A and B: the role of isoleucine.Folia Microbiol. 31, 8–14 (1986).

    Article  Google Scholar 

  • Pressman B.C.: Biological applications of ionophores.Ann. Rev. Biochem. 45, 501–530 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Sherman M.M., Hutchinson C.R.: Biosynthesis of lasalocid A. Biochemical alteration of polyether antibiotic production.J. Antibiot. 39, 1270–1280 (1986).

    PubMed  CAS  Google Scholar 

  • Sherman M.M., Yue S., Hutchinson C.R.: Biosynthesis of lasalocid A. Metabolic interrelationships of carboxylie acid precursors and polyether antibiotics.J. Antibiot. 39, 1135–1143 (1986).

    PubMed  CAS  Google Scholar 

  • Shumard R.F., Callender M.E.: Monensin, a new biologically active compounds. VI. Anticoccidical activity.Antimicrob. Agents Chemother. 1967, 369–377 (1968).

    Google Scholar 

  • Sood G.R., Robinson J.A., Ajaz A.A.: Biosynthesis of the polyether antibiotic monensin-A. Incorporation of [2-2H2]-(R)-[2-2H1]-and(S)-[2-2H1]-propionate.J. Chem. Soc. Chem. Commun. 1421–1423 (1984).

  • Vaněk Z., Pospíšil S., Tax J., Klánová K., Cimburková E., Tichý P., Voříšek J., Cudlín J., Krumphanzl V.: Biogenesis of oligoketides, p. 213–219 in Umezawa H., Demain A. L., Hata T., Hutchinson R. C. (Eds.):Trends in Antibiotic Research. Japan Antibiotic Research Association, Tokyo 1982.

    Google Scholar 

  • Westley J.W.: Polyether antibiotics: Versatile carboxylie acid ionophores produced byStreptomyces.Adv. Appl. Microbiol. 22, 177–223 (1977).

    Article  PubMed  CAS  Google Scholar 

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The authors wish to thank Dr. M. Beran for the measurement of mass spectra and Dr. S. Pospíšil who kindly provided the parent strain of this study.

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Matějů, J., Karnetová, J., Nohýnek, M. et al. Propionate and the production of monensins inStreptomyces cinnamonensis . Folia Microbiol 33, 440–446 (1988). https://doi.org/10.1007/BF02925768

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  • DOI: https://doi.org/10.1007/BF02925768

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