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Is solubility in vitro a reliable predictor of iron bioavailability?

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Abstract

In this paper we have described physiological factors that are likely to influence iron bioavailability, reviewed chemical properties of iron important to its absorption, and addressed the question posed in the title. Intestinal transit times, luminal pH, and diffusion barriers resulting from gastrointestinal mucus may affect absorption. The tendency of iron to form large-molecular-weight species and to bind to macromolecules may limit its absorption. Iron solubility following in vitro gastrointestinal digestion is a reliable predictor of ascorbic acid effects on bioavailability but not of protein effects. Solubility of lowmolecular-weight iron is better than simple solubility for predicting iron bioavailability.

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Authors and Affiliations

  1. Institute of Food Science, Stocking Hall, Cornell University, 14853, Ithaca, NY

    D. D. Miller

  2. National Dairy Council, 6300 North River Rd., 60018, Rosemont, IL

    L. A. Berner

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  1. D. D. Miller
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  2. L. A. Berner
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Miller, D.D., Berner, L.A. Is solubility in vitro a reliable predictor of iron bioavailability?. Biol Trace Elem Res 19, 11–24 (1989). https://doi.org/10.1007/BF02925446

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  • DOI: https://doi.org/10.1007/BF02925446

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