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Effects of choline-esterase inhibitor in experimental acute pancreatitis in rats

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Summary

Choline-esterase inhibitor (Cl-INH), a regulatory alpha-glycoprotein, was administered at different dosages and intervals to rats with induced acute pancreatitis. When compared to controls, treated rats showed no significant differences in the severity of histopathological lesions, such as edema and single cell necrosis. On the other hand, both mortality and extent of massive necrosis were significantly affected by Cl-INH administration regardless of the dosages.

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Authors and Affiliations

  1. Surgical Departments, University of Verona, Verona, Italy

    Sergio Vesentini, Luigi Benetti, Claudio Bassi, Antonio Bonora & Paolo Pederzoli

  2. Statistical Departments, University of Verona, Verona, Italy

    Angelo Campedelli

  3. Pathological Departments, University of Verona, Verona, Italy

    Giuseppe Zamboni & Paola Castelli

Authors
  1. Sergio Vesentini
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  2. Luigi Benetti
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  3. Claudio Bassi
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  4. Antonio Bonora
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  5. Angelo Campedelli
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  6. Giuseppe Zamboni
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  7. Paola Castelli
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  8. Paolo Pederzoli
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Vesentini, S., Benetti, L., Bassi, C. et al. Effects of choline-esterase inhibitor in experimental acute pancreatitis in rats. Int J Pancreatol 13, 217–220 (1993). https://doi.org/10.1007/BF02924443

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  • DOI: https://doi.org/10.1007/BF02924443

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