Summary
The effect of an acute gastral ethanol application and an additional induction of a pancreatic juice edema by an obstruction/hyperstimulation mechanism was studied in rats.
Neither ethanol administration nor the combination of ductal obstruction and secretory stimulation resulted in an acute pancreatitis when applied independently. A combination of these factors, however, led to the development of AP in two-thirds of the rats treated in this manner. Its severity was evaluated by the degree of extrapancreatic fat necrosis, the increase in serum amylase and lipase activities, and by histologic investigations. It is assumed that a pancreatic juice edema, provoked by pancreatic secretion at temporary ductal obstruction, could be an important cofactor in formation of ethanol-induced acute pancreatitis.
Similar content being viewed by others
References
Steer ML. Etiology and pathophysiology of acute pancreatitis. In: Go VLW, Brooks EP, DiMagno FP, Gardner JD, Lebenthal E, Scheee, GA, eds., The Exocrine Pancreas. Biology, pathobiology, and diseases. Raven Press, New York, 1986;465–474.
Strum WB, Spiro HM. Chronic pancreatitis. Ann. Int. Med. 1971; 74: 264–272.
Malagelada JR. The pathophysiology of alcoholic pancreatitis. Pancreas 1986; 1: 270–278.
Mössner J. Ätiologie, Pathogenese und Pathophysiologie der akuten Pankreatitis. Internist 1989; 30: 705–717.
Ramö OJ. Antecedent long term ethanol consumption with different diets alters the severity of experimental acute pancreatitis in rats. Gut 1987; 28: 64–69.
Jalovaara P, Apaja M. Alcohol and acute pancreatitis. An experimental study in the rat. Scand. J. Gastroenterol. 1978; 13: 703–709.
Becker V. Speicheiöde, und Pankreatitis. Akt. Chir. 1988; 23: 183–189.
Hollender LF, Lehnert P, Wanke M. Akute Pankreatitis. Eine interdisziplinare Synopsis. Urban and Schwarzenberg, Miinchen 1984.
Spormann H, Sokolowski A, Letko G. Effect of temporary ischemia upon development and histological patterns of acute pancreatitis in the rat. Path. Res. Pract. 1989; 184: 507–513.
Popper HL, Necheles H, Russel KC. Transition of pancreatic edema into pancreatic necrosis. Surg. Gynecol. Obstet. 1948; 87: 79–83.
Letko G, Sokolowski A, Spormann H, Heinrich P. A hierarchic approach for experimental investigations into the pathogenesis of acute pancreatitis. Dtsch. Z. Verdau Stoff-wechselkr. 1985; 45: 59–67.
Letko G, Siech M, Sokolowski A, Spormann H. Experimental acute pancreatitis in rats after chronic and chronic plus acute ethanol administration in combination with a pancreatic juice edema. Int. Surg. 1989; 74: 77–80.
Biochemisches Taschenbuch. HM Rauen (Hrsg.) 1964, Springer-Verlag Berlin; 2: 655
Arzneibuch der DDR. Diagnostik und Laboratoriumsmethoden. Akademieverlag Berlin, 1983.
Weber H. Mikromethode zur Bestimmung der Pankreaslipase im Serum. Dtsch. Med. Wochenschr. 1965; 90: 1170–1174.
Sachs L. Angewandte Statistik. Springer-Verlag, Berlin, 1974.
Ramö OJ, Schröder T, Kuusi T, Puolakkainen P, Mäkelä A, Jalovaara P. Long-term ethanol ingestion causes an increase of phospholipase A2 activity in acute experimental pancreatitis in rats. Surg. Res. 1986; 41: 362–366.
Becker V. Pathological anatomy and pathogenesis of acute pancreatitis. World J. Surg. 1981; 5: 303–313.
Becker V. Morphology of chronic pancreatitis. In: Scuro LA, Dagradi A. Topics in acute and chronic pancreatitis. Springer-Verlag, Berlin, 1981; 161–171.
Sokolowski A, Spormann H, Letko G. Influence of pancreatic edema and short-term ischemia of rat pancreas on lipase and amylase activities in the serum and in the pancreas. Dtsch. Z. Verdau Stoffwechselkr. 1987; 47: 119–127.
Sanfey H, Bulkley GB, Cameron JL. The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Ann. Surg. 1984; 200: 405–413.
McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 1985; 312: 159–163.
Lieber C. Metabolic effects of ethanol and its interaction with other drugs, hepatotoxic agents, vitamins, and carcinogens: A 1988 update. Sem. Liver Dis. 1988; 8: 47–68.
Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin induced gastric mucosal injury. Dig. Dis. Sci. 1987; 32: 1395–1401.
Yonei Y, Guth PH. Lipoxygenase metabolites in the rat. Gastric microvascular response to intragastric ethanol. Gastroenterol. 1989; 97: 304–312.
Letko G, Falkenberg B, Wilhelm W. Effects of trypsin, chymotrypsin, and uncoupling on survival of isolated acinar cells from the pancreas. Int. J. Pancreatol. 1989; 4: 431–442.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Siech, M., Heinrich, P. & Letko, G. Development of acute pancreatitis in rats after single ethanol administration and induction of a pancreatic juice edema. Int J Pancreatol 8, 169–175 (1991). https://doi.org/10.1007/BF02924430
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02924430