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The multielemental analysis of bone

A review

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Abstract

Numerous elements, especially metals, possess biological activity. But until now, they were of interest mainly as ingredients of foods.

This caused the grouping in essential and nonessential elements, and characteristic changes of their concentrations in tissues and body fluids of man are often accompanied by pathologic alterations. The growing interest in environmental influences on human, animal, and plant health has focused our view on the toxicity of certain elements. Often it depends on concentration (1) or chemical form (e.g., Cr3+ is essential whereas Cr6+ is venomous) if an element is vital or poisonous.

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Abbreviations

AAS:

atomic absorption spectroscopy

AES:

atomic emission spectroscopy

ASV:

anodic stripping voltammetry

CCP:

capacitively coupled plasma

CMP:

capacitive microwave plasma

CT:

computer tomography

DPASV:

difference pulse ASV

EDAX:

energy disperse analysis of X-rays

EPMA:

electron probe microanalysis

ES:

emission spectroscopy

ESR:

electron spin resonance

ETA-AAS:

electro-thermal atomization AAS

EXAFS:

extended X-ray absorption fine structure

FAAS:

flame AAS

FAES:

flame AES

GF-AAS:

graphite furnace AAS

HCES:

hollow cathode discharge emission spectroscopy

IAEA:

International Atomic Energy Agency

ICAP:

inductively coupled argon plasma

ICP:

inductively coupled plasma

INAA:

instrumental neutron activation analysis

IR:

infrared spectroscopy

ISE:

ion selective electrodes

ISFET:

ion selective field effect transistors

LAMMA:

laser microprobe mass analysis

MEA:

multielemental analysis

MIP:

microwave induced plasma

MS:

mass spectrometry

NAA:

neutron activation analysis

OAES:

optical atomic emission spectroscopy

PAA:

photon activation analysis

PAS:

photo acoustic spectroscopy

PIGE:

proton induced prompt gamma ray emission

PIXE:

particle/ or proton induced X-ray emission

RBS:

Rutherford back scattering

RNAA:

radiochemical NAA

SEM:

scanning electron microscope

SSMS:

spark source MS

TDPAC:

time differential PAC

UV:

ultra violet spectroscopy

XRF:

X-ray fluorescence analysis

XMA:

X-ray microanalysis

XRD:

x-ray diffraction

References

  1. Paracelsus Septem Defensiones, 3rd Def., (1538).

  2. J. M. Mermet and J. HubertProg. Analyt. Atom. Spectrosc. 5, 1–33 (1982).

    CAS  Google Scholar 

  3. T. NishimaICP Inf. Newsletters 8, 147 (1982).

    Google Scholar 

  4. H. Zwanziger, W. Görner, A. Vogel, and R. KrämerCalc. Tissue Int., submitted for publication (1987).

  5. T. Uchida, I. Kojima, and Ch. IidaAnal. Chim. Acta 116, 205–210 (1980).

    Article  CAS  Google Scholar 

  6. H. T. Delves,Prog. Analyt. Atom. Spectrosc. 4, 1–48 (1981).

    CAS  Google Scholar 

  7. P. Schramel, B.-J. Klose, and S. HassePres. Z. Anal. Chem. 310, 209–216 (1982).

    Article  CAS  Google Scholar 

  8. V. KrivanAngew. Chem. 91, 132–155 (1979).

    Article  CAS  Google Scholar 

  9. T. TakeuchiJ. Radioanal. Chem. 59, 545–569 (1980).

    Article  CAS  Google Scholar 

  10. L. E. Preuss and F. P. BolinProc. 4th Int. Conf. on Bone Measurement, Ontario (1978) R. B. Mazess (Ed.)

  11. J. Simon and Th. LieseFres. Z. Anal. Chem. 309, 383–385 (1981).

    Article  CAS  Google Scholar 

  12. W. D. Lehmann and H.-R. SchultenAngew. Chem. 90, 233–250 (1978).

    Article  CAS  Google Scholar 

  13. J. Veseley, D. Weiss, and K. Stulik, “Analysis with Ion-Selective Electrodes”, Ellis Horwood Series in Analytical Chemistry (1978). R. Chalmers, M. Mason (Eds.).

  14. M. J. Adams,Prog. Analyt. Atom. Spectr. 5, 153–204 (1982).

    CAS  Google Scholar 

  15. R. B. SomoanoAngew. Chem. 90, 250–258 (1978).

    Article  CAS  Google Scholar 

  16. H.-H. PerkampusNaturwiss. 69, 162–172 (1982).

    Article  CAS  Google Scholar 

  17. E. Gabriel, Y. Kato, and P. J. Rech,Fres. Z. Anal. Chem. 308, 234–238 (1981).

    Article  CAS  Google Scholar 

  18. P. M. Kidd, G. Nicolao, and N. M. SpyrouJ. Radioanal. Chem. 71, 489–507 (1982).

    CAS  Google Scholar 

  19. A. K. Susheela and M. Iha,IRCS Med. Sci.: Libr. Compend. 9, 640 (1981).

    CAS  Google Scholar 

  20. V. Iyengar,Anal. Chem. 54, 554A-560A (1982).

    Google Scholar 

  21. D. J. SimmonsBone Histomorph. 3rd Int. Workshop, 137–149 (1980).

  22. D. J. Simmons, L. A. Whiteside, and S. W. WhitsonMetab. Bone Dis. & Rel. Res. 2, 49–64 (1979).

    Article  Google Scholar 

  23. D. J. Simmons and M. CohenClin. Orthop. 149, 240–248 (1980).

    PubMed  Google Scholar 

  24. Y. K. Erataly, D. J. Simmons, and othersArchs. Oral Biol. 26, 769–777 (1981).

    Article  Google Scholar 

  25. C. M. Buczko and L. VasNature 269, 792–793 (1977).

    Article  PubMed  CAS  Google Scholar 

  26. R. E. Thiers in “Methods of Biochemical Analysis”, J. Wiley, New York, (1957), p. 274.

    Google Scholar 

  27. D. BehneJ. Clin. Chem. Clin. Biochem. 19, 115–120 (1981).

    PubMed  CAS  Google Scholar 

  28. H. Kijewski and H. D. LowitzArch. Toxicol. 50, 301–311 (1982).

    Article  PubMed  CAS  Google Scholar 

  29. E. Weinig and B. Börner,Arch. f. Toxikol. 19, 34–48 (1961).

    Article  CAS  Google Scholar 

  30. B. Sansoni and G. V. Iyengar,IAEA Tech. Rep. Ser. 197, Vienna, 57–71 (1980).

  31. G. Tölg,Naturwiss. 63, 99–100 (1976).

    Article  PubMed  Google Scholar 

  32. G. Tölg,Fres. Z. Anal. Chem. 283, 257–267 (1977).

    Article  Google Scholar 

  33. K. Garmestani, A. J. Blotcky, and E. P. RackAnal. Chem. 50, 144–147 (1978).

    Article  PubMed  CAS  Google Scholar 

  34. W. G. Dorner,GIT Fachz. Labor 26, 750–754 (1982).

    CAS  Google Scholar 

  35. M. S. Vigler, A. W. Varnes, and H. A. Strecker,Int. Labor. 51–55 (1980).

  36. S. A. KhalawanFluoride 14, 56–61 (1981).

    CAS  Google Scholar 

  37. R. Lappalainen, M. Knuutila, S. Lammi, and E. M. AlhavaActa Orthop. Scand. 53, 51–55 (1982).

    PubMed  CAS  Google Scholar 

  38. T. S. Koh,Anal. Chem. 52, 1978–1979 (1980).

    Article  PubMed  CAS  Google Scholar 

  39. G. V. Iyengar, K. Kasperek, and L. E. Feinendegen,Analyst 105, 794–801 (1980).

    Article  PubMed  CAS  Google Scholar 

  40. H. T. Delves, G. Shepard, and P. Vinter,Analyst 96, 260–273 (1971).

    Article  PubMed  CAS  Google Scholar 

  41. H. Agemian, D. P. Sturtevant, and K. D. Austen,Analyst 105, 125–130 (1980).

    Article  PubMed  CAS  Google Scholar 

  42. G. Drasch, L. V. Meyer, and G. KauertFres. Z. Anal. Chem. 311, 571–577 (1982).

    Article  CAS  Google Scholar 

  43. G. Drasch, L. V. Meyer, and G. Kauert,Fres. Z. Anal. Chem. 311, 695–696 (1982).

    Article  CAS  Google Scholar 

  44. N. Deschamps, V. Vernois, and F. Calza,J. Radioanal. Chem. 70, 109–116 (1982).

    CAS  Google Scholar 

  45. E. Kamata, R. Nakashima, K. Goto, M. Furukawa, Sh. Shibata,Anal. Chim. Acta 144, 197–203 (1982).

    Article  CAS  Google Scholar 

  46. R. Nakashima, E. Kamata, and Sh. ShibataKogai 18, 37–44 (1983).

    CAS  Google Scholar 

  47. W. T. Buckley, St. N. Huckin, J. J. Budac, and G. K. EigendorfAnal. Chem. 54, 504–510 (1982).

    Article  PubMed  CAS  Google Scholar 

  48. Z. Hölgye,Fres. Z. Anal. Chem. 315, 247–248 (1983).

    Article  Google Scholar 

  49. A. J. Jackson, L. M. Michael, and H. J. Schumacher,Anal. Chem. 44, 1064–1065 (1972).

    Article  PubMed  CAS  Google Scholar 

  50. Y. Doi, T. Aoba, M. Okazaki, J. Takahashi and Y. Moriwaki,J. Dent. Res. 60, 1053–1056 (1981).

    PubMed  CAS  Google Scholar 

  51. J. D. Termine, E. D. Eanes, D. J. Greenfield, M. U. Nylen, and R. A. Harper,Calcif. Tissue Res. 12, 73–90 (1973).

    Article  PubMed  CAS  Google Scholar 

  52. T. T. Gorsuch,Analyst 84, 135–173 (1959).

    Article  CAS  Google Scholar 

  53. Th. Liese, Dissertation, Univ. Berlin (1982).

  54. H. R. Watling and I. M. Wardale in “The Analysis of Biological Materials”, L. R. Butler, ed., Pergamon Press, Oxford (1979), pp. 69–80.

    Google Scholar 

  55. M. Blanusa and D. BreskiTalanta 28, 681–684 (1981).

    Article  CAS  PubMed  Google Scholar 

  56. G. Knapp,Ärztl. Labor. 28, 179–186 (1982).

    CAS  Google Scholar 

  57. G. F. Carter and W. B. Yeoman,Analyst 105, 295–297 (1980).

    Article  PubMed  CAS  Google Scholar 

  58. Ch. E. Gleit and W. D. Holland,Anal. Chem. 34, 1454–1457 (1962).

    Article  CAS  Google Scholar 

  59. E. E. Menden, D. Brockman, H. Choudhury, and H. G. Petering,Anal. Chem. 49, 1644–1645 (1977).

    Article  PubMed  CAS  Google Scholar 

  60. K. Klingler, E. Hauser, and H. Hiestand,Schwarz. Arch. Tierheilkd. 123, 311–321 (1981).

    CAS  Google Scholar 

  61. S. A. Witkowski, S. R. Ault, and R. W. Field,Bull. Environm. Contam. Toxicol. 28, 561–562 (1982).

    Article  CAS  Google Scholar 

  62. H. J. Tochon-Danguy, J. M. Very, M. Goeffroy, and C. A. Baud,Calcif. Tissue Res. 25, 99–104 (1978).

    Article  PubMed  CAS  Google Scholar 

  63. I. S. Parkinson, S. M. Channon, M. K. Ward, and D. N. S. Kerr, 1st Biennial Ntl. At. Spectr. Symp., Sheffield (1982).

  64. E. V. Williams,Analyst 107, 1006–1013 (1982).

    Article  PubMed  CAS  Google Scholar 

  65. A. Abu-Samra, J. S. Morris, and S. R. Koirtjohann,Anal. Chem. 47, 1475–1477 (1975).

    Article  PubMed  CAS  Google Scholar 

  66. P. Barrett, L. J. Davidowski, and Th. R. Copeland,Anal. Chem. 50, 1021–1023 (1978).

    Article  CAS  Google Scholar 

  67. Chr. A. Johnson,Anal. Chim. Acta 81, 69–74 (1976).

    Article  PubMed  CAS  Google Scholar 

  68. N. R. McQuaker, D. F. Brown, and P. D. Kluckner,Anal. Chem. 51, 1082–1084 (1979).

    Article  CAS  Google Scholar 

  69. G. A. Drasch,Sci. Total Environ. 24, 199–231 (1982).

    Article  PubMed  CAS  Google Scholar 

  70. J. Lee,ICP Inf. Newsletters 8, 553–561 (1983).

    Google Scholar 

  71. M. S. Clegg, C. L. Keen, B. Lönnerdal, and L. S. Hurley,Biol. Trace Elem. Res. 3, 107–115 (1981).

    CAS  Google Scholar 

  72. M. S. Clegg, C. L. Keen, B. Lönnerdal, and L. S. Hurley,Biol. Trace Elem. Res. 4, 145–156 (1982).

    Article  CAS  Google Scholar 

  73. Ch.-I. Siripone, G. D. Wals, and H. A. Das,J. Radioanal. Chem. 79, 35–41 (1983).

    Article  CAS  Google Scholar 

  74. S. Bajo and U. Suter,Anal. Chem. 54, 49–51 (1982).

    Article  CAS  Google Scholar 

  75. E. Scheubeck, J. Gehring, and M. Pickel,Fres. Z. Anal. Chem. 297, 112–116 (1979).

    Article  Google Scholar 

  76. E. Scheubeck, A. Nielsen, and G. Iwantscheff,Fres. Z. Anal. Chem. 294, 398–401 (1979).

    Article  CAS  Google Scholar 

  77. M. Stöppler, K. P. Mueller, and F. Backhaus,Fres. Z. Anal. Chem. 297, 107–112 (1979).

    Article  Google Scholar 

  78. H. B. Han, G. Kaiser, and G. Tölg,Anal. Chim. Acta 134, 3–11 (1982).

    Article  CAS  Google Scholar 

  79. R. Uhrberg,Anal. Chem. 54, 1906–1908 (1982).

    Article  CAS  Google Scholar 

  80. G. Werner,Z. Chem. 22, 325–332 (1982).

    CAS  Google Scholar 

  81. K. Bächmann,CRC Crit. Rev. in Anal. Chem. 12, 1–67 (1981).

    Google Scholar 

  82. M. S. W. Webb and M. L. Wordingham,Anal. Chim. Acta 26, 349–354 (1962).

    Article  CAS  Google Scholar 

  83. R. V. Jury, M. S. W. Webb, and R. J. Webb,Anal. Chim. Acta 22, 145–152 (1960).

    Article  CAS  Google Scholar 

  84. F. J. Langmyhr,Analyst 104, 993–1016 (1979).

    Article  CAS  Google Scholar 

  85. F. J. Langmyhr and I. Kjuus,Anal. Chim. Acta 100, 139–144 (1978).

    Article  CAS  Google Scholar 

  86. F. J. Langmyhr and I. M. Dahl,Anal. Chim. Acta 131, 303–306 (1981).

    Article  CAS  Google Scholar 

  87. W. Oelschläger and W. Lautenschläger,Fres. Z. Anal. Chem. 287, 28–36 (1977).

    Article  Google Scholar 

  88. H. Kawamura, G. Tanaka, and Y. Ohyagi,Spectrochim. Acta B 28, 309–318 (1973).

    Article  CAS  Google Scholar 

  89. R. C. Fry and N. Mohamed,ICP Inf. Newsletters 6, 29–30 (1980).

    Google Scholar 

  90. N. Mohamed and R. C. Fry,Anal. Chem. 53, 450–455 (1981).

    Article  PubMed  CAS  Google Scholar 

  91. I. Sarudi,Fres. Z. Anal. Chem. 303, 197–199 (1980).

    Article  CAS  Google Scholar 

  92. M. Knuutila, R. Lappalainen, S. Lammi, E. Alhava, and H. Olkkonen,Chem.-Biol. Interactions 40, 77–83 (1982).

    Article  Google Scholar 

  93. P. Brätter, D. Gawlik, J. Lausch, and U. Roesick,J. Radioanal. Chem. 37, 393–403 (1977).

    Article  Google Scholar 

  94. G. E. James, Hewlett Pack. Technical Paper, UV-1 and UV-4, (1980).

  95. P. S. I. Barry,Br. J. Int. Med. 32, 119–139 (1975).

    CAS  Google Scholar 

  96. H. H. Gossmann and S. Heilenz,Dt. Med. Wschr. 92, 2267–2269 (1967).

    CAS  Google Scholar 

  97. M. G. Rabinowitz, G. W. Wetherill, and J. D. Kopple,J. Clin. Invest. 58, 260–270 (1976).

    Article  PubMed  CAS  Google Scholar 

  98. J. A. Inglis, D. A. Henderson, and B. T. Emmerson,J. Pathol. 124, 65–76 (1978).

    Article  PubMed  CAS  Google Scholar 

  99. L. E. Wittmers, A. Alich, and A. C. Aufderheide,Am. J. Clin. Pathol. 75, 80–85 (1981).

    PubMed  CAS  Google Scholar 

  100. L. Wielopolski, J. F. Rosen, D. N. Slatkin, D. Vartsky, K. J. Ellis, and S. H. Cohn,Med. Phys. 10, 248–251 (1983).

    Article  PubMed  CAS  Google Scholar 

  101. R. L. Dahlquist and J. W. Knoll,Appl. Spectrosc. 32, 1–30 (1978).

    Article  CAS  Google Scholar 

  102. P. Kluckner and D. F. Brown, Int. Conf. “Developments in Atomic Plasma Spectral Analysis” Puerto Rico (1980) #99.

  103. F. M. Abercrombie, M. D. Silvester, and R. B. Cruz in “Advances in Chemistry” Ser., No. 172, Ultratrace Metal Analysis in Biological Science and Environment”, T. H. Risby (Ed.), (1979) chapter 2.

  104. P. Schramel and Xui-giang,ICP Inf. Newsletters 7, 429–440 (1982).

    Google Scholar 

  105. J. W. Jones and K. W. Boyer,Eastern Anal Sympos. (1977).

  106. St. G. Capar and J. H. Gould,ICP Inf. Newsletters 4, 328 (1978).

    Google Scholar 

  107. H. S. Mahanti and R. M. Barnes,Anal. Chim. Acta 151, 409–417 (1983).

    Article  CAS  Google Scholar 

  108. W. J. Kinsey and R. R. Comtois, 29th Canad. Spectr. Symp. (1982).

  109. G. J. Batra and D. K. Bewley,J. Radioanal Chem. 16, 275–280 (1973).

    Article  CAS  Google Scholar 

  110. S. Whineray, B. J. Thomas, J. H. Ternouth, and H. M. S. Davies,Int. J. Appl. Radiat. and Isotopes 31, 443–445 (1980).

    Article  CAS  Google Scholar 

  111. D. Gawlik, D. Behne, P. Brätter, W. Gatschke, H. Gessner,J. Clin. Chem. Clin. Biochem. 20, 449–507 (1982).

    Google Scholar 

  112. P. Brätter, D. Gawlik, P. Jost, J. Möller, P. Reimers,Z. Anal Chem. 283, 121–127 (1977).

    Article  Google Scholar 

  113. J. R. W. Woittiez and H. A. Das,J. Radioanal Chem. 59, 213–219 (1980).

    Article  CAS  Google Scholar 

  114. W. Gatschke, D. Gawlik, and D. Kraft,J. Clin. Chem. Clin. Biochem. 18, 403–406 (1980).

    PubMed  CAS  Google Scholar 

  115. E. Badone and R. M. Farquhar,J. Radioanal Chem. 69, 291–311 (1982).

    Article  CAS  Google Scholar 

  116. J. Korkisch, I. Steffan, P. Hille, H. Vonach, and E. Wild,J. Radioanal Chem. 68, 107–116 (1982).

    Article  CAS  Google Scholar 

  117. W. Maenhaut, R. Cornelis, J. Cafmeyer, and L. Mees,Bull Soc. Chim. Belg. 90, 115–1125 (1981).

    Google Scholar 

  118. E. M. Wild, P. Hille, and G. Rabeder,J. Radioanal. Chem. 68, 193–197 (1982).

    Article  CAS  Google Scholar 

  119. R. A. Geidel,MASCA J. 2, 13–16 (1982).

    CAS  Google Scholar 

  120. V. K. Chindhade, V. D. Gogte, A. K. Joglekar, V. N. Bhoraskar,Radiochem. Radioanal Letters 52, 141–148 (1982).

    CAS  Google Scholar 

  121. W. Sontag,KFK-Nachr. 11, 32–37 (1979).

    CAS  Google Scholar 

  122. R. Cornelis, J. Hoste, and J. Versieck,Talanta,29, 1029–1034 (1982).

    Article  CAS  PubMed  Google Scholar 

  123. W. Görner,J. Radioanal Chem. 58, 61–81 (1980).

    Article  Google Scholar 

  124. K. Eichhorn, B. Knobus, G. Rosenkranz, and H. Tellkamp,Radiol. Diagn. 21, 714–720 (1980).

    CAS  Google Scholar 

  125. D. H. Retief, P. E. Cleaton-Jones, J. Turkstra, W. J. DeWet,Arch. Oral Biol 16, 1257–1267 (1971).

    Article  PubMed  CAS  Google Scholar 

  126. M. Lundberg, R. Söremark, and H. Thilander,Odontol. Revy 16, 8–11 (1965).

    PubMed  CAS  Google Scholar 

  127. M. Lundberg, R. Söremark, and H. Thilander,Odontol Revy,16, 97–100 (1965).

    PubMed  CAS  Google Scholar 

  128. B. Maziere, D. Kuntz, and D. Comar, 4th Int. Conf. on Bone Mass., Toronto, CEA-CONF4379 (1978).

  129. G. Seiler,KFK-Nachr. KFK-2420 (1977).

  130. D. Behne, P. Brätter, D. Gawlik, C. Keller, J. Möller, and U. Rösick, 7.Wiss. Tag. Dt. Ges. f. Med. Phys., AED-CONF-134-035, (1976).

  131. R. Söremark and B. Bergman,Acta Isotopica 2, 1–15 (1962).

    Google Scholar 

  132. M. Hyvönen-Dabek,J. Radioanal. Chem. 63, 367–378 (1981).

    Article  Google Scholar 

  133. R. Wilson and St. Adelstein, NTIS-Rep. No.: NSF-RA-T-73-044 (1973).

  134. U. Lindh, D. Brunne, and G. Nordberg,Sci. Total Environ. 10, 31–37 (1978).

    Article  PubMed  CAS  Google Scholar 

  135. M. Hyvönen-Dabek, J. Räisänen, and J. T. Dabek,J. Radioanal Chem. 63, 163–175 (1981).

    Article  Google Scholar 

  136. L. Ahlgren, J.-O. Christofferson, Th. Grönberg, and S. Mattson, “X-ray fluorescence in Medicine”, Proc. Workshop, pp. 61–74 (1982).

  137. R. E. Snyder and D. C. Secord,Phys. Med. Biol. 27, 515–529 (1982).

    Article  PubMed  CAS  Google Scholar 

  138. R. Wollast and F. Burny,Calcif. Tissue Res. 8, 73–82 (1971).

    Article  PubMed  CAS  Google Scholar 

  139. B. Gonsior and M. Roth,Talanta 30, 385–400 (1983).

    Article  CAS  PubMed  Google Scholar 

  140. M. B. Engel,Histochem. 72, 443–452 (1981).

    Article  CAS  Google Scholar 

  141. W. A. P. Nicholson and D. W. Dempster,Scanning El. Microsc., pp. 517–533 (1980).

  142. D. Meyer and W. Schuler,Microchim. Acta II 365–374 (1981).

  143. E. H. Burger, 2nd Int. Congr. Cell Biol. Pap., pp. 957–965 (1980).

  144. S. Bang, 2nd Symp. CEMO “Fluoride and Bone”, Nyon (Switzerland) (1977).

  145. E.-R. Krefting, G. Lissner, and H.-J. Höhling,Scanning El. Microsc. 369–376 (1981).

  146. P. Quint, J. Althoff, and H. J. Höhling,Naturwiss,64, 389–390 (1977).

    PubMed  CAS  Google Scholar 

  147. E. M. Alhava, H. Olkkonen, J. Puittinen, V. M. Nokso-Koivisto,Acta Orthop. Scand. 48, 1–4 (1977).

    PubMed  CAS  Google Scholar 

  148. V. C. West and A. S. Malcolm,Calcif. Tissue Res. 22, 285–296 (1977).

    Article  PubMed  CAS  Google Scholar 

  149. S. A. Kerr, K. Kouris, E. Webber, and T. J. Kennett,Phys. Med. Biol. 25, 1037–1047 (1980).

    Article  PubMed  CAS  Google Scholar 

  150. J. G. Marshall,Phys. Med. Biol. 13, 15 (1968).

    Article  CAS  Google Scholar 

  151. C. Kellershohn, J. N. Rimbert, F. Soubiron, and C. Hubert,Proc. 18th Ampere Congr. 1, 289 (1974)

    Google Scholar 

  152. C. Kellershohn, J. N. Rimbert, D. Fortier, and M. Maziere,J. Physique Coll. C-6 40, 505 (1979).

    Google Scholar 

  153. J. N. Rimbert, C. Kellershohn, F. Dumas, and C. Hubert,Phys. Med. Biol. 26, 221–230 (1981).

    Article  PubMed  CAS  Google Scholar 

  154. J. N. Rimbert, C. Kellershohn, F. Dumas, D. Fortier, M. Maziere, and C. Hubert,Biochimie 63, 931–936 (1981).

    Article  PubMed  CAS  Google Scholar 

  155. H. Zumkley and H. P. Bertram,Münch. med. Wochenschr. 124, 709–711 (1982).

    CAS  Google Scholar 

  156. M. Yamaguchi, K. Sugii, and Sh. Okada,Toxicol. Lett. 10, 7–10 (1982).

    Article  PubMed  CAS  Google Scholar 

  157. H. M. Roushdy, M. K. Moloukhia, and A. T. Abdel-Fattah,Isot. Radiat. Res. 13, 19–26 (1981).

    CAS  Google Scholar 

  158. T. Wilson, J. M. Katz, and D. H. Gray,Calcif. Tissue Int. 33, 35–39 (1981).

    Article  PubMed  CAS  Google Scholar 

  159. L. E. Seargeant and R. A. Stinson,Biochem. J. 181, 247–250 (1979).

    PubMed  CAS  Google Scholar 

  160. D. Liao, D. Wang, and J. Zhang,Zhonghua Heyixue Zazhi,2, 47–48 (1982).

    CAS  Google Scholar 

  161. H. Iguchi and S. Sano,J. UOEH (Suppl.) 4, 205–215 (1982).

    Google Scholar 

  162. E. D. Brown, W. Chan, and J. C. Smith,Proc. Soc. Exp. Biol. Med. 157, 211–214 (1978).

    PubMed  CAS  Google Scholar 

  163. M. Yamaguchi, K. Sugii, and Sh. Okada,J. Pharmacobio-Dyn. 5, 388–393 (1982).

    PubMed  CAS  Google Scholar 

  164. M. Kirchgessner and A. Schnegg, 3. Spurenelem.-Symp. “Nickel”, Jena, M. Anke, ed., (1980)

  165. M. Kirchgessner, J. Perth, and A. Schnegg,Arch. Tiererernähr. 30, 805–810 (1980).

    CAS  Google Scholar 

  166. T. V. Hansen, J. Aaseth, and J. Alexander,Arch. Toxicol. 50, 195–202 (1982).

    Article  PubMed  CAS  Google Scholar 

  167. C. J. Frederickson, W. I. Manton, M. H. Frederickson, G. A. Howell, and M. A. Mallory,Brain Res. 246, 338–341 (1982).

    Article  PubMed  CAS  Google Scholar 

  168. D. L. Dresner, N. G. Ibrahim, B. R. Mascarenhas, R. D. Levere,Environ. Res. 28, 55–66 (1982).

    Article  PubMed  CAS  Google Scholar 

  169. I. M. V. DeOliveira and M. A. Pourchet-Campos,An. Esc. Super. Agric. “Luiz de Queiroz” Univ. Sao Paulo37, 1059–1076 (1980).

    CAS  Google Scholar 

  170. E. J. Murray and H. H. Messer,J. Nutr. 111, 1641–1647 (1981).

    PubMed  CAS  Google Scholar 

  171. E. J. Murray, H. H. Messer, and N. Alamoudi,J. Dent. Res. 61, 1107–1109 (1982).

    PubMed  CAS  Google Scholar 

  172. R. B. Parker and H. Toots, Fossils Making: Vertebr. Taxonomy Paleocol., Symp. Paper, pp. 197–207 (1980).

  173. K. Dominiczak, A. Put, E. Marcinkiewicz, and W. Sawarczyk,Patol. Pol. 32, 67–77 (1981).

    PubMed  CAS  Google Scholar 

  174. E. P. Polyakova and G. V. Kruteleva, Ratsion, Korml.: Osn. Povysh. Prod. S-Kh. Zhivotn., 77–81 (1981).

  175. M. J. Jackson, D. A. Jones, and R. H. T. Edwards,Clin. Physiol. 2, 333–343 (1982).

    Article  PubMed  CAS  Google Scholar 

  176. J. Kutzner, A. Sachs, and W. Grimm,Nucl. Med. 17, 63 (1978).

    CAS  Google Scholar 

  177. G. Anders, S. Tachibano, H. Schlebusch, and K. J. Munzenberg,Magnesium-Bull 3, 84–90 (1981).

    CAS  Google Scholar 

  178. E. Sabbioni, R. Pietra, and E. Marafante,J. Radioanal. Chem. 69, 381–400 (1982).

    Article  CAS  Google Scholar 

  179. M. F. Hutin, P. Netter, D. Burnel, and A. Gaucher,Rhumatologie 12, 199–203 (1982).

    CAS  Google Scholar 

  180. K. Milachowski, D. Moschinski, and B. Stawinoga,Unfallheilkunde,84, 168–174 (1981).

    PubMed  CAS  Google Scholar 

  181. G. Tanaka, H. Kawamura, and E. Namura,Health Phys. 40, 601–614 (1981).

    Article  PubMed  CAS  Google Scholar 

  182. A. Sillen,Am. J. Phys. Anthropol. 56, 131–137 (1981).

    Article  PubMed  CAS  Google Scholar 

  183. M. J. Schoeninger,Am. J. Phys. Anthropol. 51, 295–310 (1979).

    Article  PubMed  CAS  Google Scholar 

  184. Y. Suzuki,Tohoku J. Exp. Med. 129, 327–336 (1979).

    Article  PubMed  CAS  Google Scholar 

  185. J. F. Rosen, H. W. Kraner, and K. W. Jones,Toxicol. and Applied Pharmacol. 64, 230–235 (1982).

    Article  CAS  Google Scholar 

  186. T. Sato and T. Kato,J. Radioanal. Chem. 68, 175–180 (1982).

    Article  CAS  Google Scholar 

  187. L. Delaquerriere-Richardson, C. Anderson, U. M. Jorch, and M. Cook,Vet. Hum. Toxicol. 24, 401–405 (1982).

    PubMed  CAS  Google Scholar 

  188. M. J. Fauran-Clavel, J. Oustrin, J. Godin, and J. Boudene,Ann. Pharm. Fr. 40, 213–220 (1982).

    PubMed  CAS  Google Scholar 

  189. S. Kizuki,Shigaku 70, 151–161 (1982).

    PubMed  CAS  Google Scholar 

  190. J. M. Mirra, N. W. Alcock, M. E. Shils, and P. Tannenbaum,Magnesium 1, 16–33 (1982).

    CAS  Google Scholar 

  191. E. J. Murray, B. Langhans, and H. H. Messer,Nutr. Res. 1, 107–115 (1981).

    Article  CAS  Google Scholar 

  192. H. S. Hsieh and J. M. Navia,J. Nutr. 110, 1581–1588 (1980).

    PubMed  CAS  Google Scholar 

  193. W. Weidenmaier and G. Christ,Strahlentherapie 11, 765–769 (1980).

    Google Scholar 

  194. M. Itoga,Ochanomizu Igaku Zasshi 28, 359–367 (1980).

    CAS  Google Scholar 

  195. K. C. Kanwar and M. Singh,IRCS Med. Sci.: Libr. Compend. 9, 60 (1981).

    CAS  Google Scholar 

  196. A. K. Susheela and M. Iha,IRCS Med. Sci.: Libr. Compend. 9, 1021–1022 (1981).

    CAS  Google Scholar 

  197. K. A. V. R. Krishnamachari,Fluoride 15, 25–31 (1982).

    CAS  Google Scholar 

  198. V. Kontsevenko and V. Zakorko, Svinovodstvo (Moscow), 32–33 (1982).

  199. J. F. Rosen, Organ-Directed Toxic: Chem. Indices Mech., Proc. Symp., 305–310 (1981).

  200. T. Miyahara, T. Kamurasaki, Y. Oh-E, and H. Kozuka,Nippon Koshu Eisei Zasshi 27, 361–366 (1980).

    CAS  Google Scholar 

  201. T. Miyahara, M. Miyagoshi, and H. Kozuka,Nippon Koshu Eisei Zasski 27, 323–328 (1980).

    CAS  Google Scholar 

  202. M. J. Fauran-Clavel, J. C. Trombe, B. Maziere, and J. Oustrin,J. Biophys. Med. Nucl. 5, 265–268 (1981).

    CAS  Google Scholar 

  203. Y. Kono, T. Ichikawa, and M. Kondo,J. Pharmacobio-Dyn. 4, S-82 (1981).

    CAS  Google Scholar 

  204. K. C. Kanwar and M. Singh,Sci. Total Environ. 22, 79–83 (1981).

    Article  PubMed  CAS  Google Scholar 

  205. F. J. Langmyhr, T. Undo, and I. Kjuus,Anal. Chim. Acta 80, 297 (1975).

    Article  CAS  Google Scholar 

  206. F. Ishino, K. Matsumae, N. Shibata, N. Ariga, F. GoshimaBuns. Kagaku 27, 232–236 (1978).

    CAS  Google Scholar 

  207. T. Okano, T. Ichikawa, M. Kondo, and K. Ikebe,Eisei Kagaku 24, 231 (1978).

    CAS  Google Scholar 

  208. C. D. Strehlow and T. J. Kneip,Am. Ind. Hyg. Ass. J. 30, 372 (1969).

    CAS  Google Scholar 

  209. P. Holmberg, M. Hyvönen, and M. Tarvainen,J. Radioanal. Chem. 42, 169–175 (1978).

    Article  CAS  Google Scholar 

  210. C. A. Baud, R. Lagler, G. Boivin, and M. A. Boulot,Virchows Arch. PathoL Anat. 380, 283–293 (1978).

    PubMed  CAS  Google Scholar 

  211. P. Quint and H. J. Höhling,Fres. Z. Anal. Chem. 296, 411–412 (1979).

    Article  CAS  Google Scholar 

  212. E. Weinig and P. Zink,Archiv für Toxikol. 22, 255–274 (1967).

    CAS  Google Scholar 

  213. V. K. Panday, S. J. Raut, and S. D. Soman,Bull. Radiat. Prot. 4, 11–15 (1981).

    CAS  Google Scholar 

  214. S. Niese, W. Görner, A. Vogel, R. Krämer, H. Zwanziger, unpublished results (1982).

  215. K. Irlweck and H. Sorantin,Microchimica Acta II, 5–31 (1977).

    Google Scholar 

  216. G. Stein, M. Anke, R. Fünfstück, and H. J. Schneider,Z. ges. inn. Med. 34, 648–651 (1979).

    PubMed  CAS  Google Scholar 

  217. L. Singer and W. D. Armstrong,Anal. Chem. 40, 613–614 (1968).

    Article  PubMed  CAS  Google Scholar 

  218. H. Kawamura, G. Tanaka, and Y. Ohyyagi,Spectrochim. Acta B 28, 309–318 (1973).

    Article  CAS  Google Scholar 

  219. K. Niebergall, H. Brauer, W. Görner, A. Vogel, R. Krämer, and H. Zwanziger, Poster, 3rd Int. Meet. Nuclear Anal. Methods, Dresden (1983).

  220. R. M. Biltz and E. D. Pellegrino,Clin. Orthop. and Rel. Res. 129, 279–292 (1977).

    CAS  Google Scholar 

  221. N. Emslander, Ludwig-Max. Univ. München, Dissertation, (1978).

  222. P. Grandjean in “Environ. Quality and Safety”, Suppl. vol. II, Georg Thieme Publ., Stuttgart, pp. 6–75 (1975).

  223. M. F. Hutin, P. Netter, D. Burnel, G. Faure, and F. Cussenot,Ann. Med. Nancy Est. 21, 41–42 (1982).

    CAS  Google Scholar 

  224. M. J. Glimcher, L. C. Bonar, M. D. Grynpas, W. J. Landis, and A. H. Roufosse,J. Cryst. Growth,53, 100–119 (1981).

    Article  CAS  Google Scholar 

  225. H. Zwanziger, A. Vogel, R. Krämer, W. Görner, K. Neibergall, and H. Brauer,ZfK-Report 524, 317–322 (1985).

    Google Scholar 

  226. U. Lindh, D. Brune, G. Nordberg, and P. O. Wester,Sci. Total Environ. 16, 109–116 (1980).

    Article  PubMed  CAS  Google Scholar 

  227. S. Cardi and P. Delle-Femmine,Spectroscopy Letters 15, 303–312 (1982).

    Article  Google Scholar 

  228. C. M. Buczko, J. Csikai, and J. Nemeskery,Acta Phys. Acad. Sci. Hung. 53, 165–178 (1982).

    Article  CAS  Google Scholar 

  229. G. Gigante, A. Festinesi, and G. E. Gigante,Boll. Soc. Ital. Biol. Sper. 57, 2270–2276 (1981).

    PubMed  CAS  Google Scholar 

  230. W. J. Landis, M. D. Grynpas, R. M. Latinision, J. R. Martin,Microbeam Anal. 17, 121–127 (1982).

    Google Scholar 

  231. J. A. Weatherell and C. Robinson,Proc. Finn. Dent. Soc. 78, 81–92 (1982).

    PubMed  CAS  Google Scholar 

  232. E. D. Eanes, L. Powers, and J. L. Costa,Cell Calcium 2, 251–262 (1981).

    Article  CAS  Google Scholar 

  233. J. P. Robin,Progr. Analyt. Atom. Spectrosc. 5, 79–110 (1982).

    CAS  Google Scholar 

  234. W. Schrader,GIT Fachz. Lab. 26, 429–440 (1982).

    CAS  Google Scholar 

  235. J. Lausch, Doctoral Thesis, Univ. Berlin (West) (1977).

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Zwanziger, H. The multielemental analysis of bone. Biol Trace Elem Res 19, 195–232 (1989). https://doi.org/10.1007/BF02924296

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