International Journal of Pancreatology

, Volume 7, Issue 1–3, pp 117–123 | Cite as

Tumor size as a predictive factor

  • Ryoichi Tsuchiya
  • Tsukasa Tsunoda
Article
  • 19 Downloads

Summary

Is tumor size a predictive factor in carcinoma of the pancreas? In order to answer this question, the data of the Japan Pancreatic Cancer Registry from 1981 to 1987 were retrospectively analyzed.

Of the 7687 cases that were registered, 5826 cases (75.7%) were laparotomized. Out of the 5826, 2311 (39.7%) underwent resection. Postoperative deaths within 1 mo among resected cases numbered 104, and the operative mortality rate was 4.5%. The postoperative survival rates were calculated by Kaplan-Meier’s method. They clearly showed that the rates for small carcinomas (>2 cm [T1]) were significantly higher than those for the tumors larger than 2 cm (T2, T3, T4) according to the Greenwood formula. Although the survival-rate calculation excluded operative deaths and deaths of causes other than pancreatic cancer, and included islet cell carcinoma, cystadenocarcinoma, and acinar cell carcinoma, it seems that tumor size may be a predictive factor for postoperative prognosis. However, our previous study on long-term survivors (more than 5 yr) after resection on the exocrine pancreatic cancer) revealed that there was no relation between the size of tumor and the postoperative prognosis. In those long-term survivors, there was no definite or severe cancerous invasion of either the retroperitoneal tissue or the portal venous system.

It is concluded that a tumor 2 cm or smaller has a significantly better prognosis after resection than does a tumor larger than 2 cm, and it seems, in general, that tumor size may be a predictive factor. However, if the tumor does not invade the retroperitoneal tissue or the portal venous system, tumor size per se is not always a predictive factor.

Key Words

Pancreatic Cancer Registry postoperative survival rate T1 carcinoma early carcinoma long-term survivor 

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References

  1. 1.
    Japan Pancreas Society. Report of Pancreatic Cancer Registry. 1981–1987 (in Japanese).Google Scholar
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    Tsuchiya R, Oribe T, and Noda T. Size of the tumor and other factors influencing prognosis of carcinoma of the head of the pancreas. Am. J. Gastroenterol. 1985; 80: 459–462.PubMedGoogle Scholar
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    Tsuchiya R, Tomioka T, Izawa K, Noda T, Yamamoto K, Tsunoda T, Harada N, Yamaguchi T, Yoshino R, Miyamoto T, and Eto T. Collective review of small carcinomas of the pancreas. Ann. Surg. 1986; 203: 77–81.PubMedCrossRefGoogle Scholar
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    Tsuchiya R, Harada N, Tsunoda T, Miyamoto T, and Ura K. Long-term survivors after operation on carcinoma of the pancreas. Int. J. Pancreatol. 1988; 3: 491–498.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • Ryoichi Tsuchiya
    • 1
  • Tsukasa Tsunoda
    • 1
  1. 1.The Second Department of SurgeryNagasaki University School of MedicineNagasakiJapan

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