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Diagnosis of chronic pancreatitis by means of a sonographic secretin test

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Summary

The pancreatic duct can be demonstrated today by sonography in about 90% of all persons examined. In 159 persons, aged 18–79 yr, we measured sonographically the pancreatic duct diameter before and after intravenous secretin injection. After secretin stimulation, 20 healthy controls and 90 patients without pancreatic disease showed a distinct pancreatic duct dilatation of 93 and 94% of basal duct diameter lasting only several minutes. No distinct secretin-induced duct enlargement was observed in 35 of 40 patients with chronic pancreatitis. Patients with chronic pancreatitis and circumscript duct stenosis even had a marked and longerlasting duct dilatation of 156% of basal duct diameter after secretin stimulation. This study showed a high reliability of the sonographic secretin test in the diagnosis of chronic pancreatitis—even in an early stage—recording a sensitivity of 92.5%, a specificity of 93%, and a predictive value of 84%.

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Authors and Affiliations

  1. Department of Internal Medicine, Municipal Hospital Kassel, University Teaching Hospital of the Philipps-University, Mönchebergstr. 41-43, D-3500, Kassel, Marburg, Germany

    Joachim Glaser, Ortwin Mann & Jürgen Pausch

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  1. Joachim Glaser
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  2. Ortwin Mann
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  3. Jürgen Pausch
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Glaser, J., Mann, O. & Pausch, J. Diagnosis of chronic pancreatitis by means of a sonographic secretin test. Int J Pancreatol 15, 195–200 (1994). https://doi.org/10.1007/BF02924194

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  • DOI: https://doi.org/10.1007/BF02924194

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