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Tissue plasminogen activator, plasminogen activator inhibitor, and other parameters of fibrinolysis in the early stages of taurocholate acute pancreatitis in rats

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Summary

It is well known that fibrinolytic activity in the early stages of acute experimental pancreatitis (AEP) as assessed by euglobulin lysis time (ELT) is depressed. The aim of this study was to evaluate changes in the fibrinolytic system in the early stages of taurocholate AEP in rats. Tissue plasminogen activator (t-PA) activity, plasminogen activator inhibitor 1 (PAI-1) activity, plasminogen, α1 proteinase inhibitor (α1PI), α2 antiplasmin (α2AP), antithrombin III (AT III), fibrinogen, and ELT were measured 0.5, 1, 3, and 6 h after the induction of taurocholate AEP in rats, as well as in sham-operated animals and the control group, which was not submitted to any operation. T-PA activity decreased significantly after 3 and 6 h of AEP; PAI activity had a time course reverse to t-PA and was parallel to α1 PI activity. ELT was slightly prolonged after 0.5, 1, and 3 h, whereas α2 AP activity and plasminogen levels increased significantly; AT III activity was increased after 1 h in comparison to control group. Sham operation caused nonsignificant changes in fibrinolysis. Increase of PAI activity and decrease of t-PA could be a reasonable explanation for inhibited plasma euglobulin fibrinolytic activity noted in the early period of AEP.

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Authors and Affiliations

  1. Gastroenterology Department, Medical Academy, ul.M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland

    Grazyna Rydzewska, Slawomir Kosidlo & Antoni Gabryelewicz

  2. Nephrology, Medical Academy, Bialystok, Poland

    Andrzej Rydzewski

Authors
  1. Grazyna Rydzewska
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  2. Slawomir Kosidlo
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  3. Antoni Gabryelewicz
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  4. Andrzej Rydzewski
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Rydzewska, G., Kosidlo, S., Gabryelewicz, A. et al. Tissue plasminogen activator, plasminogen activator inhibitor, and other parameters of fibrinolysis in the early stages of taurocholate acute pancreatitis in rats. Int J Pancreatol 11, 161–168 (1992). https://doi.org/10.1007/BF02924181

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  • DOI: https://doi.org/10.1007/BF02924181

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