Abstract
The locus encoding for meprin activity in kidney was found polymorphic in the rat. The BDIV and COP strains that carried theMep-1 a allele had high meprin concentration in the kidney, while the ACI, BN, LE and LEW strains that carried theMep-1 b allele had low meprin levels. TheMep-1 a allele that controlled the high activity enzyme was expressed in a dominant fashion in the (BN × COP) F1 progeny. The backcross studies showed that the segregation of alleles at theMep-1 and theGlo-1 loci was normal and that the genes were linked (x 2 = 4.06,P < 0.05). The map distance between theMep-1 andGlo-1 genes was 41 ± 4 centimorgans.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beynon R J, Shannon J D and Bond J S 1981 Purification and characterization of a metalloendoproteinase from mouse kidney.Biochem. J. 199: 591–598
Bond J S, Beynon R J, Reckelhoff J F and David C S 1984Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice.Proc. Natl. Acad. Sci. USA 81: 5542–5545
Cohen N 1979 Evolution of the major histocompatibility complex in vertebrates: a saga of convergent gene evolution?Transplant. Proc. 11: 1118–1122
Dupont B, Smithwick E M, Oberfield S E, Lee T D and Levine L S 1977 Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency).Lancet 11: 1309–1312
Lalley P A and McKusick V A 1985 Report of the committee on comparative mapping.Cytogenet. Cell Genet. 40: 536–566
Lowry O H, Rosebrough N J, Farr A L and Randall R J 1951 Protein measurement with the Folin phenol reagent.J. Biol. Chem. 193: 265–275
MacLean C J, Morton N E, Elston R C and Yee S 1976 Skewness in commingled distributions.Biometrics 32: 695–699
Nadeau J H, Collins R L and Klein J 1982 Organization and evolution of the mammalian genome.Genetics 102: 583–598
Reckelhoff J F, Beynon R J and Bond J S 1984 Degradation of radioiodinated polypeptides by kidney brush-borders of meprin-sufficient and meprin-deficient mice.Proc. Soc. Exp. Biol. Med. 176: 219
Reckelhoff J F, Bond J S, Beynon R J, Savarirayon S and David C S 1985 Genetic analysis mapping the Mep-1 gene, that controls a kidney proteinase activity, telometric to the H-2D locus.Fed. Proc, Fed. Am. Soc. Exp. Biol. 44: 559
Stolc V, Kunz H W and Gill III T J 1980 The linkage of glyoxylase-I to the major histocompatibility complex in the rat.J. Immunol. 125: 1167–1170
Szymura J M and Klein J 1982 Mapping of the mouse Upg-1 locus.Immunogenetics 16: 89–90
Womack J E, Yan D L S and Potier M 1981 Gene for neuraminidase activity on mouse chromosome 17 near H-2: pleiotropic effect on multiple hydrolases.Science 212: 63–65
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stolc, V. Genetics of meprin in the rat. J. Genet. 65, 13–17 (1986). https://doi.org/10.1007/BF02923531
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02923531