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Proopiomelanocortin mrna expression by small cell bladder carcinoma associated with cushing’s syndrome: diagnostic contribution of in situ hybridization

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Abstract

A case of ectopic ACTH secretion by primary small-cell carcinoma of the urinary bladder is described. The patient, a 38-year-old woman, presented with Cushing's syndrome. Although immunocytochemistry of the tumor for ACTH and corticotropin-releasing factor yielded negative results, in situ hybridization demonstrated a conclusive signal for proopiomelanocortin messenger RNA. This case report shows the value of in situ hybridization in diagnostic pathology.

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Authors and Affiliations

  1. Departments of Clinical Endocrinology and Urology, “Polyklinic” Hospital of Athens, 3 Pireaus Str, 105 52, Athens, Greece

    Elli Lakka-Papadodima, Yvonne Dimoula, George Kontogeorgos, Zissoula Manika, John Kiayias & Harafambos Theodorou

  2. Department of Pathology, General Hospital of Athens, Greece

    Elli Lakka-Papadodima, Yvonne Dimoula, George Kontogeorgos, Zissoula Manika, John Kiayias & Harafambos Theodorou

Authors
  1. Elli Lakka-Papadodima
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  2. Yvonne Dimoula
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  4. Zissoula Manika
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  6. Harafambos Theodorou
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Lakka-Papadodima, E., Dimoula, Y., Kontogeorgos, G. et al. Proopiomelanocortin mrna expression by small cell bladder carcinoma associated with cushing’s syndrome: diagnostic contribution of in situ hybridization. Endocr Pathol 5, 66–71 (1994). https://doi.org/10.1007/BF02921372

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