Abstract
The economics of using Na2CO3 rather than CaCO3 as the neutralizing agent in fumaric acid production byRhizopus arrhizus is investigated and compared with the benzene route. Because sodium fumarate, unlike calcium fumarate, is soluble, downstream processing is simplified by requiring less equipment and no heat, and also allows the reuse of cells. In spite of a fumaric acid productivity (g/L/h) 2.4 x lower than the CaCO3 case, the Na2CO3 alternative with cell reuse has a higher rate of return. However, with the current cost of petroleum, the selling price of fumaric acid from the benzene route is half as much as from an idealized Na2CO3 fermentation.
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Gangl, I.C., Weigand, W.A. & Keller, F.A. Economic comparison of calcium fumarate and sodium fumarate production byRhizopus arrhizus . Appl Biochem Biotechnol 24, 663–677 (1990). https://doi.org/10.1007/BF02920287
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DOI: https://doi.org/10.1007/BF02920287