Skip to main content
Log in

Transforming growth factor-beta in a model of IgA switching

  • B Cell Differentiation
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Kawanishi H, Saltzman LE, Strober W: Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B cells to sIgA B cells in vitro. J Exp Med 1983;157:433–450.

    Article  PubMed  CAS  Google Scholar 

  2. Benson EB, Strober W: Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract. J Immunol 1988;140:1874–1882.

    PubMed  CAS  Google Scholar 

  3. Sakal H, Miyazaki M, Endoh M, Nomoto Y: Increase of IgA-specific switch T cells in patients with IgA nephropathy. Clin Exp Immunol 1989; 78:378–382.

    Google Scholar 

  4. Coffman RL, Lebman DA, Shrader B: Transforming growth factor-β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 1989;170:1039–1044.

    Article  PubMed  CAS  Google Scholar 

  5. Lebman DA, Lee FD, Coffman RL: Mechanism for transforming growth factor-β and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures. J Immunol 1990; 144:952–959.

    PubMed  CAS  Google Scholar 

  6. Sonoda E, Matsumoto R, Hitoshi Y, Ishii T, Sugimoto M, Araki S, Tominaga A, Yamaguchi N, Takatsu K: Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med 1989;170:1415–1420.

    Article  PubMed  CAS  Google Scholar 

  7. Kim P-H, Kagnoff MF: Transforming growth factor-β1 is a costimulator for IgA production. J Immunol 1990;144:3411–3416.

    PubMed  CAS  Google Scholar 

  8. Matsuoka M, Yoshida K, Maeda T, Usuada S, Sakano H: Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell 1990;62:135–142.

    Article  PubMed  CAS  Google Scholar 

  9. Helfgott DC, May LT, Sthoeger Z, Tamm I, Sehgal PB: Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts. J Exp Med 1987;166:1300–1309.

    Article  PubMed  CAS  Google Scholar 

  10. Taffet SM, Singhel KJ, Overholtzer JF, Shurtleff SA: Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP. Cell Immunol 1989;120:291–300.

    Article  PubMed  CAS  Google Scholar 

  11. Cornwell RD, Golenbock DT, Proctor RA: Lipopolysaccharide, but not lethal infection, releases tumor necrosis factor in mice. Adv Exp Med Biol 1990;256:585–588.

    PubMed  CAS  Google Scholar 

  12. Moses HL, Yang EY, Pietenpol JA: TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights. Cell 1990;63:245–247.

    Article  PubMed  CAS  Google Scholar 

  13. Kehri JH, Taylor AS, Delsing GA, Roberts AB, Sporn MB, Fauci AS: Further studies of the role of transforming growth factor-β in human B cell function. J Immunol 1989;143:1868–1874.

    Google Scholar 

  14. Cross David, Cambier John C: Transforming growth factor β1 has differential effects on B cell proliferation and activation antigen expression. J Immunol 1990;114:432–439.

    Google Scholar 

  15. Haughton G, Arnold LW, Bishop GA, Mercolino TJ: The CH series of murine B cell lymphomas: Neoplastic analogues of Ly-1+ normal B cells. Immunol Rev 1986;93:35–51.

    Article  PubMed  CAS  Google Scholar 

  16. Mercolino TJ, Arnold LW, Haughton G: Phosphatidyl choline is recognized by a series of Ly-1+ murine B cell lymphomas specific for erythrocyte membranes. J Exp Med 1986;163:155–165.

    Article  PubMed  CAS  Google Scholar 

  17. Corley RB, LoCascio NJ, Ovnic M, Haughton G: Two separate functions of class II (Ia) molecules: T-cell stimulation and B-cell excitation. Proc Natl Acad Sci USA 1985;82:516–520.

    Article  PubMed  CAS  Google Scholar 

  18. Bishop GA, Haughton G: Induced differentiation of a transformed clone of Ly-1+B cells by clonal T cells and antigen. Proc Natl Acad Sci USA 1986; 83:7410–7414.

    Article  PubMed  CAS  Google Scholar 

  19. Swain SL, Dutton RW, McKenzie D, Helstrom H, English M: Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion. J Immunol 1988; 140:4224–4230.

    PubMed  CAS  Google Scholar 

  20. Stockdale AM, Dul JL, Wiest DL, Digel M, Argon Y: The expression of membrane and secreted immunoglobulin during the in vitro differentiation of the murine B cell lymphoma CH12. J Immunol 1987;139:3527–3535.

    PubMed  CAS  Google Scholar 

  21. Kunimoto DY, Harriman GR, Strober W: Regulation of IgA differentiation in CH12.LX B cells by lymphokines. J Immunol 1988;141:713–720.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

D.Y.K. is funded by an Alberta Heritage Clinical Investigatorship and the work is funded by the Medical Research Council of Canada.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kunimoto, D.Y. Transforming growth factor-beta in a model of IgA switching. Immunol Res 10, 400–403 (1991). https://doi.org/10.1007/BF02919730

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02919730

Keywords

Navigation