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The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment

  • B Cell Differentiation
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Conclusion

The prompt switching to the expression of different non-IgM/IgD isotypes in PP and LN during acute, de novo GC reactions at the two types of sites suggests intrinsic differences in their microenvironments as the basis for isotype preference.

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Authors and Affiliations

  1. Department of Biology, University of Pennsylvania, 415 South University Avenue, 19104-6018, Philadelphia, PA, (USA)

    John J. Cebra, Ava C. Logan & Peter D. Weinstein

Authors
  1. John J. Cebra
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  2. Ava C. Logan
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  3. Peter D. Weinstein
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Cebra, J.J., Logan, A.C. & Weinstein, P.D. The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment. Immunol Res 10, 393–395 (1991). https://doi.org/10.1007/BF02919728

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  • DOI: https://doi.org/10.1007/BF02919728

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