Skip to main content
Log in

Regulation of the antibody class switch to IgA

  • B Cell Differentiation
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Stavnezer-Nordgren J, Sirlin S: Specificity of immunoglobulin heavy-chain switch correlates with activity of germline heavy-chain genes prior to switching. EMBO J 1986;5:95–102.

    PubMed  CAS  Google Scholar 

  2. Yancopoulos GD, Depinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW: Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J 1986;5:3259–3266.

    PubMed  CAS  Google Scholar 

  3. Stavnezer, J, Radcliffe G, Lin, Y-C, Nictupski J, Berggren L, Sitia R, Severinson E: Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci USA 1988;85:7704–7708.

    Article  PubMed  CAS  Google Scholar 

  4. Berton MT, Uhr JM, Vitetta ES: Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon γ. Proc Natl Acad Sci USA 1989;86:2829–2833.

    Article  PubMed  CAS  Google Scholar 

  5. Rothman P, Lutzker S, Cook W, Coffman R, Alt FW: Mitogen plus interleukin 4 induction of Cε transcripts in B lymphoma cells. J Exp Med 1988; 168:2385–2389.

    Article  PubMed  CAS  Google Scholar 

  6. Esser C, Radbruch A: Rapid induction of transcription of unrearranged Sγ1 switch regions in activated murine B cells by interleukin 4. EMBO J 1989;8:483–488.

    PubMed  CAS  Google Scholar 

  7. Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW: Mitogen- and IL-4-regulated expression of germ-line Igγ2b transcripts: Evidence for directed heavy chain class switching. Cell 1988;53:177–184.

    Article  PubMed  CAS  Google Scholar 

  8. Severinson E, Fernandez C, Stavnezer J: Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination. Eur J Immunol 1990;20:1079–1084.

    Article  PubMed  CAS  Google Scholar 

  9. Radoliffe G, Lin Y-C, Julius M, Marcu KB, Stavnezer J: Structure of germ-line immunoglobulin α heavy-chain RNA and its location on polysomes. Mol Cell Biol 1990;10:382–386.

    Google Scholar 

  10. Lebman DA, Lee FD, Coffman RL: Mechanism for transforming growth factor β and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures. J Immunol 1990; 144:952–959.

    PubMed  CAS  Google Scholar 

  11. Lebman DA, Nomura DY, Coffman RL, Lee FD: Molecular characterization of germ-line immunoglobulin α transcripts produced during transforming growth factor type β-induced isotype switching. Proc Nat Acad Sci USA. 1990;87:3962–3966.

    Article  PubMed  CAS  Google Scholar 

  12. Kezak M: Selection of initiation sites by eukaryotic ribosomes: Effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. Nucleic Acids Res 1984;12:3873–3893.

    Article  Google Scholar 

  13. Kozak M: Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eakaryotic ribosomes. Cell 1986; 44:283–292.

    Article  PubMed  CAS  Google Scholar 

  14. Kozak M: At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987;196:947–950.

    Article  PubMed  CAS  Google Scholar 

  15. Kozak M: Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. Proc Nat Acad Sci USA 1990;87: 8301–8305.

    Article  PubMed  CAS  Google Scholar 

  16. Stavnezer J, Shockett P, Lin Y-C, Saikh KU, Xu M: The L29 mouse B lymphoma: Regulation of the antibody class switch. Cytokines 1990;3:154–169.

    CAS  Google Scholar 

  17. Lin Y-C, Stavnezer J: Promoter for the germ-line immunoglobulin α constant region gene. Evidence that an ATF sequence motif regulates transcription, submitted for publication.

  18. Sen R, Baltimore D: Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705–716.

    Article  PubMed  CAS  Google Scholar 

  19. Hai T, Liu F, Coukos WJ, Green MR: Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selcetively form DNA-binding heterodimers. Genes Dev 1989;3:2083–2090.

    Article  PubMed  CAS  Google Scholar 

  20. Distel RT, Ro HS, Rosen BS, Groves DL, Spiegelman BM: Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: Direct participation of c-fos. Cell 1987;49:835–844.

    Article  PubMed  CAS  Google Scholar 

  21. Kim SJ, Glick A, Sporn MB, Roberts AB: Characterization of the promoter region of the human transforming growth factor-β1 gene. J Biol Chem 1989;264:402–408.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lin, YC.A., Shockett, P. & Stavnezer, J. Regulation of the antibody class switch to IgA. Immunol Res 10, 376–380 (1991). https://doi.org/10.1007/BF02919724

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02919724

Keywords

Navigation