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Multiple roles of leu-8/MEL-14 in leukocyte adhesion and function

  • Mucosal Cell Traffic
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Summary

Leu-8 and its murine homologue MEL-14 are members of a new family of adhesion molecules encoded on chromosome-1 that share common structural features, including lectin-like domains and tandem repeats homologous to complement binding proteins. The expression of Leu-8 is rapidly down-regulated during cell activation, both at the transcriptional level, and by a rapid post-translational event at the cell membrane, probably involving direct cleavage of the molecule from the cell surface. Lymphocytes that express Leu-8/MEL-14 bind selectively to HEVs in peripheral lymph nodes, and MEL-14 on neutrophils is thought to be important in the initial localization of neutrophils to sites of inflammation. In addition to its role in leukocyte adhesion, there is evidence that the Leu-8 molecule plays a role in cell function. Anti-Leu-8 monoclonal antibody increases suppressor activity of CD4+, Leu-8+T cells for immunoglobulin synthesis, and anti-Leu-8 directly inhibits differentiation of Leu-8+ B cells. Together these findings indicate that the Leu-8 molecule in common with other cellular adhesion molecules is important not only in cellular adhesion, but also in modification of cell function.

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Authors and Affiliations

  1. Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Md., USA

    Stephen P. James, Yohko Murakawa, Marjorie E. Kanof & Maria Berg

  2. Division of Gastroenterology, University of Maryland at Baltimore, 22 S. Greene Street, 21201, Baltimore, MD, (USA)

    Stephen P. James

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  1. Stephen P. James
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  2. Yohko Murakawa
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  3. Marjorie E. Kanof
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  4. Maria Berg
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James, S.P., Murakawa, Y., Kanof, M.E. et al. Multiple roles of leu-8/MEL-14 in leukocyte adhesion and function. Immunol Res 10, 282–292 (1991). https://doi.org/10.1007/BF02919708

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