Skip to main content
SpringerLink
Log in

Selective T cell immunoregulatory function and contrasuppression in the mucosal immune system

  • T Cell Subsets
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gershon RK, Eardley DD, Durum S, Green DR, Shen FW, Yamauchi K, Cantor H, Murphy DB: Contrasuppression; Novel immunoregulatory activity. J Exp Med 1981;153:1533–1546.

    Article  PubMed  CAS  Google Scholar 

  2. Ptak W, Flood PM, Janeway CA, Mareinkiewicz RJ, Green DR: Immunoregulatory role of Ig isotypes: I. Induction of contrasuppressor T cells for contact sensitivity responses by antibodies of the IgM, IgG1, and IgG3 isotypes. J Immunol 1988; 141:756–764.

    PubMed  CAS  Google Scholar 

  3. Braley-Mullen H: Requirement for B cells for activation of contrasuppressor T cells by type III pneumococcal polysaccharide. J Immunol, 1990; 144:2465–2472.

    PubMed  CAS  Google Scholar 

  4. Rohrer JW, Kemp JD: Function and regulation of SRBC induced contrasuppressor T cells which modulate suppression of MOPC-315 cell secretory differentiation in vivo and in vitro. Immunol Res 1988;7:45–55.

    Article  PubMed  CAS  Google Scholar 

  5. Kelly CJ, Nellson EG: Contrasuppression in autoimmunty: Abnormal contrasuppression facilitates expression of nephritogenic effector T cells and interstitial nephritis in kdkd mice. J Exp Med 1987;165:107–123.

    Article  PubMed  CAS  Google Scholar 

  6. Green DR, Gold J, Martin SS, Gershon R, Gershon RK; Microenvironmental immunoregulation: Possible role of contrasuppressor cells in maintaining immune responses in gut-associated lymphoid tissues. Proc Natl Acad Sci USA 1982; 79:889–892.

    Article  PubMed  CAS  Google Scholar 

  7. Kiyono H, Green DR, McGhee JR: Constrasuppression in the mucosal immune system. Immunol Res 1988;7:67–81.

    Article  PubMed  CAS  Google Scholar 

  8. Beagley KW, Fujihashi K, Aicher W, Xu J, Kiyono H, Eldridge JH, Bruce MG, Taguchi T, Green DR, Singh B, Everson MP, Koopman WP, McGhee JR: Mucosal Homeostasis: Role of interleukins, isotype-specific factors and contrasuppression in the IgA response. Immunol Invest 1989;18:77–89.

    Article  PubMed  CAS  Google Scholar 

  9. Suzuki I, Kitamura K, Kiyono H, Kurita T, Green DR, McGhee JR: Isotype-specific immunoregulation: Evidence for a distinct subset of T contra-suppressor cells for IgA responses in murine Peyer's patches. J Exp Med 1986;164:501–516.

    Article  PubMed  CAS  Google Scholar 

  10. Taguchi T, Aicher WK, Mega J, Fujihashi K, Beagley KW, McGhee JR, Hirasawa M, Otake S, Kiyono H: CD3+, CD8+ intraepithelial lymphocytes (IELs) produce both IL-5 and IL-6. FASEB J 1990;4:A2037.

    Google Scholar 

  11. Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA: Recognition of cluster of differentiation 1 antigens by human CD4− CD8− cytolytic T lymphocytes. Nature 1990;341:447–450.

    Article  Google Scholar 

  12. Schoenbeck S, Hammen MJ, Kagnoff MF:Vicia villosa agglutinin separates freshly isolated Peyer's Patch T cells into interleukin 5-or interleukin 2-producing subsets. J Exp Med 1989;169:1491–1496.

    Article  PubMed  CAS  Google Scholar 

  13. Lehner T: Antigen presenting, contrasuppressor human T cells. Immunol Today, 1986;7:87–92.

    Article  Google Scholar 

  14. Lehner T, Brines R: Phenotypic and functional characterization of human contrasuppressor cell interactions. Immunol Res 1988;7:33–44.

    Article  PubMed  CAS  Google Scholar 

  15. Fellows R, Fortune F, Bergmeier LA, Lehner T: The effect of immunization with a 14-kDa streptococcal antigen on primate T cell and B cell responses. Eur J Immunol 1988;18:559–564.

    Article  Google Scholar 

  16. Fortune F, Lehner T: Phenotypic expression ofVicia villosa binding T cell subsets, as markers of contrasuppressor cells in systemic lupus erythematosus. Clin Exp Immunol 1988;74:100–104.

    PubMed  CAS  Google Scholar 

  17. Raedler A, Lenz HJ, Sandgren K, deWeerth A, Enversen S, Schreiber S, Thiele HG, Greten H: Phenotype and functional properties ofVicia villosa agglutinin (VVA) binding T cells in patients with Crohn's disease: Detection of contrasuppressor activity in patients lacking extra-intestinal manifestations, abscesses and fistulas. Clin Exp Immunol 1988;74:264–269.

    PubMed  CAS  Google Scholar 

  18. Raedler A, Enversen S, Sandgren K, deWeerth A, Thiele HG, Greten H: Evidence for contrasuppression in patients with Crohn's disease; in McDermott (ed). Inflammatory Bowel Disease: Current Status and Future Approach. Amsterdam, Elsevier, 1988.

    Google Scholar 

  19. Raedler A, Schreiber S, deWeerth A, Brinkmann B, et al: Evidence for contrasuppression in patients with Crohn's disease. Adv Exp Med Biol 1988;237:655–663.

    PubMed  CAS  Google Scholar 

  20. Elson CO, Graeff AS, James SP, Strober W: Covert suppressor T cells in Crohn's disease. Gastroenterology 1980;80:1513–1521.

    Google Scholar 

  21. Salomon P, Panja A, Mayer L: Functional and phenotypic characteristics of T cell lines derived from mucosal biopsies of normal and inflammatory bowel disease intestine. Gastroenterology 1990;98:A472.

    Google Scholar 

  22. Kimura A, Wigzell H, Holmquist G, Ersson B, Carlsson P: Selective affinity fractionation of murine cytotoxic T lymphocytes (CTL): Unique lectin specific binding of the CTL associated surface glycoprotein T145. J Exp Med 1979;149:473–484.

    Article  PubMed  CAS  Google Scholar 

  23. Kaufmann Y, Berke G: Cell surface glycoproteins of cytotoxic T lymphocytes induced in vivo and in vitro. J Immunol 1981;126:1443–1446.

    PubMed  CAS  Google Scholar 

  24. Conzeimann A, Pink R, Acuto O, Mach J-P, Dolivo S, Nabholz M: Presence of T145 on cytolytic T cell lines and their lectin-resistant mutants. Eur J Immunol 1980;10:860–868.

    Article  Google Scholar 

  25. Tollefsen SE, Kornfeld R: The B4 lectin fromVicia villosa seeds interacts with N-acetylgalactosamine amine residues alpha-linked to serine or threonine residues in cell surface glycoproteins. J Biol Chem 1983;258:5172–5276.

    PubMed  CAS  Google Scholar 

  26. Chilson OP, Kelly-Chilson AE: Mitogenic lectins bind to the antigen receptor on human lymphocytes. Eur J Immunol 1989;19:389–396.

    Article  PubMed  CAS  Google Scholar 

  27. Abrignani S, Cammisuii S:Vicia villosa lectin is a mitogen for mouse T lymphocytes. Int Arch Allergy Appl Immunol 1988;85:446–451.

    PubMed  CAS  Google Scholar 

  28. Almeida BM, Eveson JW, Challacombe SJ: Preliminary characterization and distribution ofVicia villosa binding cells in human tonsils. Virchows Arch [A] A 1989;414:173–178.

    Article  CAS  Google Scholar 

  29. Lang I, Banga JP, Varey A, Gunn H, Cooke A, Roitt IM: Direct staining of mouse T lymphoblasts with flouresceinatedVicia villosa lectin. Immunology 1982;46:769–776.

    PubMed  CAS  Google Scholar 

  30. MacDonald HR, Mach J-P, Schreyer M, Zaech P, Cerottini J-C: Flow cytofluorometric analysis of the binding ofVicia villosa lectin to T lymphoblasts: Lack of correlation with cytolytic function. J Immunol 1981;126:883–886.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Md., USA

    Lorenz Braun-Elwert & Stephen P. James

  2. Division of Gastroenterology, University of Maryland at Baltimore, 21201, Baltimore, MD, (USA)

    Stephen P. James

Authors
  1. Lorenz Braun-Elwert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen P. James
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braun-Elwert, L., James, S.P. Selective T cell immunoregulatory function and contrasuppression in the mucosal immune system. Immunol Res 10, 211–217 (1991). https://doi.org/10.1007/BF02919695

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02919695

Keywords

Search

Navigation