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Eosinophil IgE receptor and CD23

  • Eosinophil IgE Receptor
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Abstract

In the present review, eosinophil FcεRII was compared to CD23, a differentiation marker of B cells. Biochemical analysis revealed that molecules of similar molecular weight were immunoprecipitated from eosinophils and B cells by an anti-CD23 monoclonal antibody (mAb) or by BB10, an anti-eosinophil FcεRII. By flow cytometry, a correlation was found between the binding of anti-CD23 mAb and myeloma IgE. However, a low expression of different epitopes of CD23 was observed in various hypereosinophilic patients. Northern blot analysis of eosinophil RNA with the cDNA probe of CD23 revealed a weak message in only 3 of the 6 patients expressing membrane CD23. The inhibition by anti-CD23 mAbs of IgE-mediated cytotoxicity and IgE binding to eosinophils clearly indicated the participation of CD23 or a related moclecule in IgE-dependent eosinophil functions. However, the differential effects of anti-CD23 mAbs on eosinophils and B cells suggest major differences in the characteristics of the molecule expressed by eosinophils and by B cells.

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Authors and Affiliations

  1. Centre d’Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U167-CNRS 624, Institut Pasteur, HP 245, F-59019, Lille Oedex, France

    Monique Capron, Marie-José Truong, Delphine Aldebert, Valérie Gruart, Béatrice Tourvieille & André Capron

  2. Department of Internal Medicine, Osaka University Hospital, Osaka, Japan

    Masaki Suemura

  3. Centre de Recherches en Allergie, Hôpital Notre Dame, Montréal, Québec, Canada

    Guy Delespesse

Authors
  1. Monique Capron
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  2. Marie-José Truong
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  3. Delphine Aldebert
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  4. Valérie Gruart
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  5. Masaki Suemura
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  6. Guy Delespesse
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  7. Béatrice Tourvieille
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  8. André Capron
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Capron, M., Truong, MJ., Aldebert, D. et al. Eosinophil IgE receptor and CD23. Immunol Res 11, 252–259 (1992). https://doi.org/10.1007/BF02919131

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