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Expression of IgA and IgM Fc receptors on murine T lymphocytes

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Abstract

Fc receptors are induced on T cells following activation via the TCR. T cells that express Fc receptors transiently have the ability to use two different cognate systems: the TCR and immunoglobulins bound to the Fc receptors. The studies discussed in this article are focused on the Fcα and Fcμ receptors that can be induced on certain subsets of murine T lymphocytes. The article emphasizes the role of the T cell receptor for antigen in the expression of Fcα and Fcμ receptors on murine T cells and reviews experimental observations that suggest significant molecular heterogeneity of these Fc receptors. The finding that regulation of expression of Fcα receptors and Fcμ receptors on T lymphocytes is linked to cellular activation via the CD3/TCR complex implies that these Fc receptors might mediate important functions in the biology and pathology of T cells.

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References

  1. Lynch RG, Sandor M: Fc receptors on T and B Lymphocytes. Am Soc Microbiol Monogr 1990;305–334.

  2. Ravetch JV, Anderson CL: FcγR family: Proteins, transcripts and genes. Am Soc. Microbiol Monogr 1990;211–235.

  3. Unkeles JC, Scigliano E, Freedman VH: Structure and function of human and murine receptors for IgE. Annu Rev Immunol 1988;6:251–281.

    Article  Google Scholar 

  4. Conrad DH: FcσRII/CD23: The low affinity receptor for IgE. Annu Rev Immunol 1990;8:623–646.

    PubMed  CAS  Google Scholar 

  5. Lynch RG: Immunoglobulin-specific suppressor T cells. Adv Immunol 1987;40:135–151.

    PubMed  CAS  Google Scholar 

  6. Kiyono H, Phillips JO, Colwell DE, Koopman SM, McGhee JR: Isotype specificity of helper T-cell clones: Fcα receptors regulate T- and B-collaboration of IgA responses. J Immunol 1984;133:1087–1089.

    PubMed  CAS  Google Scholar 

  7. Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD: Functional analysis of two human subpopulations: Help and suppression of B cell responses by T cells bearing receptors for IgM (Tμ) or IgG (Tγ). J Exp Med 1977;146:184–200.

    Article  PubMed  CAS  Google Scholar 

  8. Sandor M, Waldschmidt TJ, Williams KR, Lynch RG: IgA induced avidity maturation of IgA Fc receptors on murine T lymphocytes. J Immunol 1990;144:4562–4570.

    PubMed  CAS  Google Scholar 

  9. Mosmann TR, Coffman RL: Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145–174.

    Article  PubMed  CAS  Google Scholar 

  10. Sandor M, Gajewski T, Thorson J, Kemp JD, Fitch FW, Lynch RG: CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the IL-4 producing T helper cell type 2 subset. J Exp Med 1990;171:2171–2176.

    Article  PubMed  CAS  Google Scholar 

  11. Coico R, Finkelman F, Swenson CD, Siskind GW, Thorbecke GF: Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro. Proc Natl Acad Sci USA 1988;85:559–563.

    Article  PubMed  CAS  Google Scholar 

  12. Fridman WH, Sautes C: Immunoglobulin-binding factors. Am Soc Microbiol Monogr 1990;335–355.

  13. Adachi M, Yodoi J, Noro N, Masuda T, Uchino H: Murine IgA binding factors produced by FcμR(+)_ T cells: Role of FcγR(+) cells for the induction of FcαR and formation of IgA-binding factors in ConA-activated cells. J Immunol 1984;133:65–71.

    PubMed  CAS  Google Scholar 

  14. Gajewski TF, Shell GR, Nau G, Fitch FW: Regulation of T cell activation: Differences among T cell subsets. Immunol Rev 1988;111:79.

    Article  Google Scholar 

  15. Taniguchi T: Regulation of cytokine gene expression. Annu Rev Immunol 1988;6:439–464.

    Article  PubMed  CAS  Google Scholar 

  16. Sandor M, Houlden B, Hedrick S, Weinstock J, Bluestone J, Lynch RG: In vitro and in vivo activation of murine γ/δ TCR+ T cells induces the expression of IgA, IgM and IgG Fc receptors. J Immunol 1992;148: 2363–2370.

    PubMed  CAS  Google Scholar 

  17. Mostov KE, Friedlander M, Blobel G: The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 1984;308:37–43.

    Article  PubMed  CAS  Google Scholar 

  18. Mestecky J, McGhee JR: Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol 1987;40:153–245.

    Article  PubMed  CAS  Google Scholar 

  19. Mathur, A, Lynch RG, Köhler G: The contribution of constant region domains to the binding of murine IgM to Fcμ receptors on T cells. J Immunol 1988;140:143–147.

    PubMed  CAS  Google Scholar 

  20. Lynch RG, Sandor M, Waldschmidt TJ: Receptors for IgA and IgE on T and B lymphocytes: Development, regulation and function. Res Immunol 1990;141:241–248.

    Article  PubMed  CAS  Google Scholar 

  21. Crago SS, Word CJ, Tomasi TB: Antisera to the secretory component recognize the murine Fc receptor for IgA. J Immunol 1989;142:3909–3912.

    PubMed  CAS  Google Scholar 

  22. Shen L, Lasser R, Fanger MW: My43 a monoclonal antibody that reacts with human myeloid cells inhibits monocyte IgA binding and triggers function. J Immunol 1989; 143:4117–4122.

    PubMed  CAS  Google Scholar 

  23. Maliszweski CR, March CJ, Schoenborn MA, Gimpel S, Shen L: Expression cloning of a human Fc receptor for IgA. J Exp Med 1990;172: 1665–1672.

    Article  Google Scholar 

  24. Monteiro RC, Kubawa H, Cooper MD: Cellular distribution, regulation and biochemical nature of an Fcα receptor in human. J Exp Med 1990;171:597.

    Article  PubMed  CAS  Google Scholar 

  25. Noro N, Adachi M, Yashuda K, Masuda T, Yodoi J: Murine IgA binding factors (IgA-Bf) suppressing IgA production: Characterization and target specificity of IgA-Bf. J Immunol 1986;136:2910.

    PubMed  CAS  Google Scholar 

  26. Aicher WK, McGhee ML, McGhee JR, Eldridge JH, Beagley KW, Meyer TF, Kiyono H: Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-Kd FcαR protein and development of an anti FcαR antiserum. J Immunol 1990;145:1745–1753.

    PubMed  CAS  Google Scholar 

  27. Aruffo A, Seed B: Molecular cloning of two CD7 (T cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J 1987;6:3313–3318.

    PubMed  CAS  Google Scholar 

  28. Ohno T, Kubayawa H, Sanders SK, Cooper MD: Biochemical nature of an Fcμ receptor on human B-lineage cells. J Exp Med 1990;172:1165–1175.

    Article  PubMed  CAS  Google Scholar 

  29. Uher F, Sandor M, Medgyesi GA, Gergely J: Receptors for IgM on rat spleen cells. Cell Immunol 1981;60: 168–173.

    Article  PubMed  CAS  Google Scholar 

  30. Kiyono H, McGhee JR: Mucosal T cell networks: Role of FcαR+ T cells and IBfα in regulation of IgA response. Int Rev Immunol 1987;2:157.

    Article  PubMed  CAS  Google Scholar 

  31. Hickman S, Kulczycki A, Lynch RG, Kornfeld S: Studies of the mechanism of tunicamycin inhibition of IgA and IgE secretion by plasma cells. J Biol Chem 1977;252: 4402–4408.

    PubMed  CAS  Google Scholar 

  32. Stafford HA, Knight KL, Fanger MW: Receptors for IgA on rabbit lymphocytes. II. Characterization of their binding parameters for IgA. J Immunol 1982;129:2201–2205.

    Google Scholar 

  33. Yodoi J, Adachi M, Masuda T: Induction of FcαR on murine lymphocytes by IgA in vitro. J Immunol 1982;128:888–894.

    PubMed  CAS  Google Scholar 

  34. O’Grady JH, Looney RJ, Anderson CL: The valence for ligand of the human mononuclear phagocyte 72 Kd high affinity IgG receptor is one. J Immunol 1986;137:2307–2310.

    PubMed  CAS  Google Scholar 

  35. Metzger H, Alcaraz G, Hohman R, Kinet JP, Priblude V, Quatro R: The receptor with high affinity for immunoglobulin E. Annu Rev Immunol 1986;4:419–470.

    Article  PubMed  CAS  Google Scholar 

  36. Feinstein A, Richardson NE, Yorick BD, Hughes-Jones NC: Immunoglobulin M confirmational change is a signal for complement activation; in Celada F, Schumaker VN, Sercarz EE (eds): Protein Conformation as Immunological Signal. New York, Plenum Publishing, 1983, pp 45–57.

    Google Scholar 

  37. Urnovitz HB, Chang Y, Scott M, Fleischman J, Lynch RG: IgA:IgM and IgA:IgA hybrid hybridomas secrete heteropolymeric immunoglobulins that are polyvalent and bispecific. J Immunol 1988;140:558–563.

    PubMed  CAS  Google Scholar 

  38. Springer TA: Adhesion receptors of the immune system. Nature 1990; 346:425–434.

    Article  PubMed  CAS  Google Scholar 

  39. Teeraratkul P, Lynch RG: IgM Fc receptors on T cells and membrane IgM molecules on B cells can function as accessory adhesion molecules in the conjugation of T and B cells. FASEB J 1991;5:A1464.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    Matyas Sandor, Alexander Ibraghimov, Michael G. Rosenberg, Phataraporn Teeraratkul & Richard G. Lynch

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  1. Matyas Sandor
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  2. Alexander Ibraghimov
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  3. Michael G. Rosenberg
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  4. Phataraporn Teeraratkul
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  5. Richard G. Lynch
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Sandor, M., Ibraghimov, A., Rosenberg, M.G. et al. Expression of IgA and IgM Fc receptors on murine T lymphocytes. Immunol Res 11, 169–180 (1992). https://doi.org/10.1007/BF02919124

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