Skip to main content
Log in

Pharmacological modification of immunoregulatory activity of lymphocytes: Facts and potential1

  • Guest Editorial Reviews
  • Published:
Survey of Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Reinherz, E.L.; Schlossman, S.F.: Regulation of the immune response: inducer and suppressor T-lymphocyte subsets in human beings. New Engl. J. med.505: 370–373 (1980).

    Google Scholar 

  2. Reinherz, E.L.; Kung, P.C.; Goldstein, G.; Levey, R.H.; Schlossman, S.F.: Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc. natn. Acad. Sci. USA77: 1588–1592 (1980).

    Article  CAS  Google Scholar 

  3. Reinherz, E.L.; Morimoto, C.; Fitzgerald, K.A.; Hussey, R.E.; Daly, J.F.; Schlossman, S.F.: Heterogeneity of human T4+ inducer T-cells defined by a monoclonal antibody that delineates two functional subpopulations. J. Immun.128: 463–468 (1982).

    PubMed  CAS  Google Scholar 

  4. Thomas, Y.; Rogozinski, L.; Irigoyen, O.H.; Shen, H.H.; Talle, M.A.; Goldstein, G.; Chess, L.: Functional analysis of human T-cell subsets defined by monoclonal antibodies. V. Suppressor cells within the activated OKT4+ population belong to a distinct subset. J. Immun.128: 1386–1390 (1982).

    PubMed  CAS  Google Scholar 

  5. Van Wauwe, J.P.; DeMey, J.R.; Gossens, J.G.: OKT3: a monoclonal anti-human T-lymphocyte with potent mitogenic properties. J. Immun.124: 2708–2713 (1980).

    PubMed  Google Scholar 

  6. Meuer, S.C.; Hodgdon, J.C.; Cooper, D.A.; Hussay, R.E.; Fitzgerald, K.A.; Schlossman, S.F.; Reinherz, E.L.: Human cytotoxic T-cell clones directed at autologous virus transformed targets: further evidence for lineage of genetic restriction to T4 and T8 surface glycoproteins. J. Immun.131: 186–190 (1983).

    PubMed  CAS  Google Scholar 

  7. Weite, K.; Platzer, E.; Wang, C.Y.; Kan, E.A.R.; Moore, M.A.S.; Mertelsmann, R.: OKT8 antibody inhibits OKT3-induced IL2 production and proliferation in OKT8+ cells. J. Immun.131: 2356–2361 (1983).

    Google Scholar 

  8. Moroz, C.; Stevens, R.H.: Suppression of immunoglobulin production in normal human B-lymphocytes by two T-cell subsets distinguished following in vitro treatment with adenosine. Clin. Immunol. Immunopathol.75: 44–51 (1980).

    Article  Google Scholar 

  9. Birch, R.E.; Polmar, S.H.: Pharmacological modification of immunoregulatory T-lymphocytes. I. Effect of adenosine, H1, and H2 histamine agonists upon T-lymphocyte regulation of B-lymphocyte differentiation in vitro. Clin. exp. Immunol.48: 218–230 (1982).

    PubMed  CAS  Google Scholar 

  10. Birch, R.E.; Rosenthal, A.K.; Polmar, S.H.: Pharmacological modulation of immunoregulatory T-lymphocytes. II. Modulation of T-lymphocyte cell surface characteristics. Clin. exp. Immunol.48: 231–238 (1982).

    PubMed  CAS  Google Scholar 

  11. Londos, C.; Wolff, J.: Two distinct adenosine sensitive sites on adenylate cyclase. Proc. natn. Acad. Sci. USA74: 5482–5486 (1977).

    Article  CAS  Google Scholar 

  12. Polmar, S.H.; Birch, R.E.; Mandler, R.; Rudolph, S.A.: Adenosine and cyclic nucleotides in the modulation of immune responses; in Berne, Rall, Rubio, Regulatory function of adenosine, pp. 249–259 (Nijhoff, The Hague 1983).

    Google Scholar 

  13. Birch, R.E.; Polmar, S.H.: Adenosine induced immunosuppression: the relationship of adenosine induced biochemical events to the alteration of lymphocyte surface phenotype and the development of suppressor activity (submitted for publication, 1984).

  14. Rocklin, R.E.: Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. J. clin. Invest.57: 1051–1058 (1976).

    Article  PubMed  CAS  Google Scholar 

  15. Garovoy, M.R.; Reddish, M.A.; Rocklin, R.E.: Histamine-induced suppressor factor (HSF): inhibition of helper T-cell generation and function. J. Immun.130: 357–361 (1983).

    PubMed  CAS  Google Scholar 

  16. Rocklin, R.E.; Greineder, D.; Littman, B.H.; Melmon, K.L.: Modulation of cellular immune function in vitro by histamine receptor-bearing lymphocytes: mechanism of action. Cell. Immunol.37: 162–173 (1978).

    Article  PubMed  CAS  Google Scholar 

  17. Rocklin, R.E.; Blidy, A.; Kamal, M.: Physiochemical characterization of human histamine-induced suppressor factor. Cell Immunol.76: 243–252 (1983).

    Article  PubMed  CAS  Google Scholar 

  18. Beer, DJ.; Rosenwasser, L.J.; Dinarello, C.A.; Rocklin, R.E.: Cellular interactions in the generation and expression of histamine induced suppressor activity. Cell Immunol.69: 101–112 (1982).

    Article  PubMed  CAS  Google Scholar 

  19. Goodwin, J.S.; Webb, D.R.: Regulation of the immune response by prostaglandins. Clin. Immunol. Immunopathol.15: 106–122 (1980).

    Article  PubMed  CAS  Google Scholar 

  20. Rola-Pleszczynski, M.; Borgeat, P.; Sirois, P.: Leukotriene B4 induces human suppressor lymphocytes. Biochem. biophys. Res. Commun.108: 1531–1537 (1982).

    Article  PubMed  CAS  Google Scholar 

  21. Rola-Pleszczynski, M.; Sirois, P.: Leukotrienes as immunoregulators; in Piper, Leukotrienes and other lipoxygenase products, pp. 234–240 (Wiley & Sons, London 1983).

    Google Scholar 

  22. Berne, R.M.; Knabb, R.M.; Ely, S.W.; Rubio, R.: Adenosine in the local regulation of blood flow: a brief overview. Fed. Proc.42: 3136–3142 (1983).

    PubMed  CAS  Google Scholar 

  23. Kammer, G.M.; Birch, R.E.; Polmar, S.H.: Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T-lymphocyte generation. J. Immun.130: 1706–1712 (1983).

    PubMed  CAS  Google Scholar 

  24. Mandler, R.; Birch, R.E.; Polmar, S.H.; Kammer, G.M.; Rudolph, S.A.: Abnormal adenosine-induced immunosuppression and cAMP metabolism in T-lymphocytes of patients with systemic lupus erythematosus. Proc. natn. Acad. Sci. USA79: 7542–7546 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported by research grants (AI 17570, AI 20086 and CA 38353) from the US Public Health Service, National Institutes of Health, DHHS.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Polmar, S.H. Pharmacological modification of immunoregulatory activity of lymphocytes: Facts and potential1. Surv. immunol. Res. 3, 274–279 (1984). https://doi.org/10.1007/BF02919043

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02919043

Keywords

Navigation