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Major histocompatibility complex-linked transport proteins and antigen processing

  • MHC Proteins and Antigen Processing
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Abstract

The major histocompatibility complexes of mice, rats and humans each contain a pair of related genes,Tap-1 andTap-2, that encode members of a large superfamily of proteins having similar structure and function. The TAP-1 (previously called HAM1 in the mouse) and TAP-2 (HAM2) proteins each contain 6–8 predicted membrane-spanning α helices, and a cytoplasmic domain containing a putative ATP-binding site. Recent evidence suggests that a functional TAP-1/TAP-2 heterodimer is required for efficient presentation of antigens to CD8+ cytotoxic T cells. This heterodimer resides in the membrane of the endoplasmic reticulum (ER), and probably functions to transport peptides (produced in the cytoplasm) into the ER lumen for binding to MHC class I molecules.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Box 678 MCV Station, 23298-0678, Richmond, Va., USA

    John J. Monaco

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  1. John J. Monaco
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Monaco, J.J. Major histocompatibility complex-linked transport proteins and antigen processing. Immunol Res 11, 125–132 (1992). https://doi.org/10.1007/BF02918617

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  • DOI: https://doi.org/10.1007/BF02918617

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