Skip to main content
SpringerLink
Log in

A family of trans-acting factors with distinct regulatory functions control expression of MHC class II genes

  • MHC Class II Genes and Molecules, Symposium (Part I)
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Benacerraf B: Role of MHC gene products in immune regulation. Science 1981;212:1229–1238.

    Article  PubMed  CAS  Google Scholar 

  2. Guillemot F, Auffray C, Orr HT, et al: MHC antigen genes; in Hames BD, Glover DM (eds): Molecular Immunology. Frontiers in Molecular Biology. Oxford, IRL Press, 1988, pp 81–143.

    Google Scholar 

  3. Foon KA, Todd RF III: Immunologic classification of leukemia and lymphoma. Blood 1986;68:1–31.

    PubMed  CAS  Google Scholar 

  4. Collins T, Pober JS, Strominger JL: Physiologic regulation of class II major histocompatibility complex gene expression; in Solheim BG, Moller E, Ferrone S (eds). HLA Class II Antigens. Berlin, Springer, 1986, pp 14–31.

    Google Scholar 

  5. Hanafusa T, Chiovato L, Doniach D, et al: Aberrant expression of HLA-DR antigen on thyrocytes in Graves’ Disease: relevance for autoimmunity. Lancet 1983;12:1111–1115.

    Article  Google Scholar 

  6. Griscelli C, Fisher A, Grospierre B, et al: Clinical and immunological aspects of combined immunodeficiency with defective expression of HLA antigens; in Griscelli C, Vossen J (eds): Progress in Immunodeficiency Research and Therapy I. New York, Excerpta Medica, 1984, pp 19–26.

    Google Scholar 

  7. Halper J, Fu SF, Wang CY, et al: Patterns of expression of ‘Ia-like’ antigens during the terminal stages of B cell development. J Immunol 1978; 120:1480–1484.

    PubMed  CAS  Google Scholar 

  8. Accolla RS: Human B cell variants immunose-lected against a single Ia subset have lost expression of several Ia antigen subsets. J Exp Med 1983;157:1053–1058.

    Article  PubMed  CAS  Google Scholar 

  9. Long EO, Mach B, Accolla RS: Ia-negative B cell variants reveal a coordinate regulation in the transcription of the HLA class II gene family. Immunogenetics 1984;19:349–353.

    Article  PubMed  CAS  Google Scholar 

  10. Gladstone P, Pious D: Stable variants affecting B cell alloantigens in human lymphoid cells. Nature 1978;271:459–461.

    Article  PubMed  CAS  Google Scholar 

  11. Loosmore S, Gladstone P, Pious D, et al: Control of HLA-DR antigen expression at the pretranslational level: comparison of an HLA-DR positive lymphoblastoid cell line and its HLA-DR negative variant. Immunogenetics 1982;15:139–150.

    Article  PubMed  CAS  Google Scholar 

  12. Calman AJ, Peterlin BM: Mutant human B cell lines deficient in class II major histocompatibility complex transcription. J Immunol 1987;139:2489–2495.

    PubMed  CAS  Google Scholar 

  13. Accolla RS, Carra G, Guardiola J: Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma. Proc Natl Acad Sci USA 1985;82:5145–5149.

    Article  PubMed  CAS  Google Scholar 

  14. Accolla RS, Scarpellino L, Carra G, et al: Transacting element(s) operating across species barriers positively regulate the expression of major histocompatibility complex class II genes. J Exp Med 1985;162:1117–1133.

    Article  PubMed  CAS  Google Scholar 

  15. Accolla RS, Jotterand-Bellomo M, Scarpellino L, et al: aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression. J Exp Med 1986;164:369–374.

    Article  PubMed  CAS  Google Scholar 

  16. Robinson J, Sieff C, Delia D, et al: Expression of cell surface HLA-DR. HLA-ABC and glycophorin during erythroid differentiation. Nature 1981; 289:68–71.

    Article  PubMed  CAS  Google Scholar 

  17. Guy K, Van Heyningen V, Dewar E, et al: Enhanced expression of human Ia antigens by chronic lymphocytic leukemia cells following treatment with 12-0-tetradecanocylphorbol-B-acetate. Eur J Immunol 1983;13:156–159.

    Article  PubMed  CAS  Google Scholar 

  18. Carrel S, Mach J-P, Ferremi P, et al: Expression of class II Ia antigens on non-hematopoietic tumor cells; in Solheim BG, Moller E, Ferrone S (eds): HLA Class II Antigens. Berlin, Springer, 1986, pp 412–428.

    Google Scholar 

  19. Long EO: In search of a function for the invariant chain associated with Ia antigens. Surv Immunol Res 1985;4:27–34.

    PubMed  CAS  Google Scholar 

  20. Collins T, Korman AJ, Wake CT, et al: Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA 1984;81:4917–4921.

    Article  PubMed  CAS  Google Scholar 

  21. Accolla RS, Carra G, Buchegger F, et al: The human Ia-associated invariant chain is synthesized in Ia-negative B cell variants and is not expressed on the cell surface of both Ia-negative and Ia-positive parental cells. J Immunol 1985; 134:3265–3271.

    PubMed  CAS  Google Scholar 

  22. De Preval C, Lisowska-Grospierre B, Loche M, et al: A trans-acting class II regulatory gene unlinked to the MHC controls the expression of HLA class II genes. Nature 1985;318:291–293.

    Article  PubMed  Google Scholar 

  23. Gladstone P, Pious D: Identification of a transacting function regulating HLA-DR expression in DR-negative B cell variant. Somatic Cell Genet 1980;6:285–298.

    Article  PubMed  CAS  Google Scholar 

  24. Yang Z, Accolla RS, Pious D, et al: Two distinct genetic loci regulating class II gene expression are defective in human mutant and patients cell lines. EMBO J 1988;7:1965–1972.

    PubMed  CAS  Google Scholar 

  25. Salter RD, Alexander J, Levine F, et al: Evidence for two trans-acting genes regulating HLA class II antigen expression. J Immunol 1985;135:4235–4238.

    PubMed  CAS  Google Scholar 

  26. Howell DN, Berger AE, Cresswell P: Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent. Immunogenetics 1982;17:411–425.

    Article  Google Scholar 

  27. Boss JM, Strominger JL: Regulation of transfected class II major histocompatibility complex gene in human fibroblasts. Proc Natl Acad Sci USA 1986;83:9139–9143.

    Article  PubMed  CAS  Google Scholar 

  28. Dorn A, Durand B, Marfing C, et al: Conserved major histocompatibility complex class II boxes-X and Y—are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci USA 1987;84:6249–6253.

    Article  PubMed  CAS  Google Scholar 

  29. Dorn A, Bollekens J, Staub A, et al: A multiplicity of CCAAT box-binding proteins. Cell 1987;50:863–872.

    Article  PubMed  CAS  Google Scholar 

  30. Sherman PA, Basta PV, Ting JP: Upstream DNA sequences required for tissue-specific expression of HLA-DR alpha gene. Proc Natl Acad Sci USA 1987;84:4254–4258.

    Article  PubMed  CAS  Google Scholar 

  31. Miwa K, Doyle C, Strominger JL: Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes. Proc Natl Acad Sci USA 1987;84:4939–4944.

    Article  PubMed  CAS  Google Scholar 

  32. Guardiola J, Scarpellino L, Carra G, et al: Stable integration of mouse DNA into Ia-negative human B-lymphoma cells causes reexpression of the human Ia-positive phenotype. Proc Natl Acad Sci USA 1986;83:7415–7418.

    Article  PubMed  CAS  Google Scholar 

  33. Koch W, Candeias S, Guardiola J, et al: An enhancer factor defect in a mutant Burkitt lymphoma cell line. J Exp Med 1988;167:1781–1790.

    Article  PubMed  CAS  Google Scholar 

  34. Reith W, Satola S, Herrero-Sanchez C, et al: Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 1988;53:897–906.

    Article  PubMed  CAS  Google Scholar 

  35. Liou H-C, Boothby MR, Glimcher LH: Distinct cloned class II MHC DNA-binding proteins recognize the X box transcription element. Science 1988;242:69–71.

    Article  PubMed  CAS  Google Scholar 

  36. Didier DK, Shiffenbauer J, Woulfe SL, et al: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc Natl Acad Sci USA 1988;85:7322–7326.

    Article  PubMed  CAS  Google Scholar 

  37. Latron F, Jotterand-Bellomo M, Maffei A, et al: Active suppression of major histocompatibility class II gene expression during differentiation from B cells to plasma cells. Proc Natl Acad Sci USA 1988;85:2229–2233.

    Article  PubMed  CAS  Google Scholar 

  38. Dellabona P, Latron F, Maffei A, et al: Transcriptional control of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells. J Immunol 1988;142:2902–2910.

    Google Scholar 

  39. Zlotnick A, Shimonkevitz RP, Gefter ML, et al: Characterization of the γ-interferon-mediated induction of antigen-presenting ability in P388 D1 cells. J Immunol 1983;131:2814–2820.

    Google Scholar 

  40. Maffei A, Scarpellino L, Bernard M, et al: Distinct mechanisms regulate class II gene expression in B cells and macrophages. J Immunol 1987;139:942–948.

    PubMed  CAS  Google Scholar 

  41. Bottger EC, Blanar MA, Flavell RA: Cycloheximide, an inhibitor of protein synthesis, prevent g-interferon-induced expression of class II mRNA in a macrophage cell line. Immunogenetics 1988; 28:215–220.

    Article  PubMed  CAS  Google Scholar 

  42. Polla BS, Poljak A, Geier SG, et al: Three distinct signals can induce class II gene expression in a murine pre-B cell line. Proc Natl Acad Sci USA 1986;83:4878–4882.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France

    Paolo Dellabona

  2. Istituto di Chimica Biologica, Università di Verona, Italy

    Giuseppe Carra

  3. Istituto di Scienze Immunologiche, Università di Verona Policlinico di Borgo Roma, I-37100, Verona, Italy

    Roberto S. Accolla, Leonardo Scarpellino & Silvia Sartoris

Authors
  1. Roberto S. Accolla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paolo Dellabona
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Leonardo Scarpellino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giuseppe Carra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Silvia Sartoris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Accolla, R.S., Dellabona, P., Scarpellino, L. et al. A family of trans-acting factors with distinct regulatory functions control expression of MHC class II genes. Immunol Res 9, 20–33 (1990). https://doi.org/10.1007/BF02918476

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02918476

Keywords

Search

Navigation