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The enigmatic specificity of γδ T cells

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Abstract

In most scientific investigations, the study of mechanism follows the study of function. For example, αβ T cells were shown to be important mediators of immunity before the interaction between the T cell receptor (TCR) and peptide-MHC complexes was understood. However, sometimes the study of function follows from the study of mechanism. Research of γδ T cell receptors falls into this category. The γ chain of the TCR was first cloned in 1984, which then led to the discovery of γδ T cells in 1985. Since then, research has focused on understanding ligands of the γδ TCR with the hope of better understanding the function of γδ T cells. An initial assumption was that γδ T cells, like αβ T cells, recognize peptides bound to MHC molecules; however, recent data indicate that γδ T cells are not biased towards MHC recognition in the same way as αβ T cells. Although there are intriguing new insights, the specificity and function of γδ T cells remains a mystery.

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  1. Department of Biology, University of California, San Diego, 9500 Gilman Drive San Diego, 92093-0687, San Diego, CA, (USA)

    Bennett G. Weintraub & Stephen M. Hedrick

  2. Cancer Center, University of California, San Diego, Calif., USA

    Bennett G. Weintraub & Stephen M. Hedrick

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Weintraub, B.G., Hedrick, S.M. The enigmatic specificity of γδ T cells. Immunol Res 14, 163–175 (1995). https://doi.org/10.1007/BF02918214

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