Skip to main content

Transport and expression of HLA class-II glycoproteins

Immunologic Research volume 9, pages 190–199 (1990)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Kaufman JF, Auffray C, Korman AJ, et al: The class II molecules of the human and murine major histocompatibility complex. Cell 1984; 36: 1–13.

    PubMed  Article  CAS  Google Scholar 

  2. Jones PP, Murphy DB, Newgill D, et al: Detection of a common polypeptide chain in I-A and I-E subregion immunoprecipitation. Mol Immunol 1978; 16: 51–60.

    Article  Google Scholar 

  3. Claesson-Welsh L, Barber PE, Larhammar D, et al: The gene encoding the human class II antigen-associated gamma chain is located on chromosome 5. Immunogenetics 1984; 20: 89–93.

    PubMed  Article  CAS  Google Scholar 

  4. Yamamoto K, Floyd-Smith G, Franche V, et al: The gene encoding the Ia-associated invariant chain is located on chromosome 18 in the mouse. Immunogenetics 1985; 21: 83–90.

    PubMed  Article  CAS  Google Scholar 

  5. Long EO, Strubin M, Wake CT, et al: Isolation of cDNA clones for the p33 invariant chain associated with HLA-DR antigens. Proc Natl Acad Sci USA 1983; 80: 5714–5718.

    PubMed  Article  CAS  Google Scholar 

  6. Claesson L, Larhammar D, Rask L, et al: cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. Proc Natl Acad Sci USA 1983; 80: 7395–7399.

    PubMed  Article  CAS  Google Scholar 

  7. Strubin M, Berte C, Mach B: Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J 1986; 5: 3483–3488.

    PubMed  CAS  Google Scholar 

  8. Koch N, Lauer W, Habicht J, et al: Primary structure of the gene for the mouse Ia-antigen associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J 1987; 6: 1677–1683.

    PubMed  CAS  Google Scholar 

  9. Sant AJ, Schwartz BD, Cullen SE: Identification of a new component in the murine Ia molecular complex. J Exp Med 1983; 158: 1979–1992.

    PubMed  Article  CAS  Google Scholar 

  10. Sant AJ, Cullen SE, Giacolletto KS, et al: Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan. J Exp Med 1985; 162: 1916–1934.

    PubMed  Article  CAS  Google Scholar 

  11. Machamer CE, Cresswell P: Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens. J Immunol 1982; 129: 2564–2569.

    PubMed  CAS  Google Scholar 

  12. Blum JS, Cresswell P: Intracellular transport of class II HLA antigens; in Pernis B, Silverstein SC, Vogel MJ (eds): Processing and Presentation of Antigens. San Diego, Academic Press, 1988, pp 43–51.

    Google Scholar 

  13. Bjorkman PJ, Saper MA, Samraoui B, et al: Structure of the human class I histocompatibility antigen HLA-A2. Nature 1987; 329: 506–512.

    PubMed  Article  CAS  Google Scholar 

  14. Brown JM, Jardetzky T, Saper MA, et al: A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 1988; 332: 845–850.

    PubMed  Article  CAS  Google Scholar 

  15. Chestnut RW, Colon SM, Grey HM: Requirements for the processing of antigens by antigen-presenting B cells. I. Functional comparison of B cell tumors and macrophages. J Immunol 1982; 129: 2382–2388.

    Google Scholar 

  16. Unanue ET: Antigen presenting function of the macrophage. Annu Rev Immunol 1984; 2: 395–428.

    PubMed  Article  CAS  Google Scholar 

  17. Streicher HZ, Berkower IJ, Busch M, et al: Antigen conformation determines processing requirements for T-cell activation. Proc Natl Acad Sci USA 1984; 81: 6831–6835.

    PubMed  Article  CAS  Google Scholar 

  18. Takahashi H, Cease KB, Berzofsky JA: Identification of proteases that process distinct epitopes on the same protein. J Immunol 1989; 142: 2221–2229.

    PubMed  CAS  Google Scholar 

  19. Diment S, Stahl P: Macrophage endosomes contain proteases which degrade endocytosed protein ligands. J Biol Chem 1985; 260: 15311–15317.

    PubMed  CAS  Google Scholar 

  20. Roederer M, Bowser R, Murphy RF: Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes. J Cell Physiol 1987; 131: 200–209.

    PubMed  Article  CAS  Google Scholar 

  21. Buus S, Sette A, Colon SM, et al: Isolation and characterization of antigen Ig complexes involved in T cell recognition. Cell 1986; 47: 1071–1077.

    PubMed  Article  CAS  Google Scholar 

  22. Pernis B: Internalization of lymphocyte membrane components. Immunol Today 1985; 6: 45–49.

    Article  CAS  Google Scholar 

  23. Machy P, Barbet J, Leserman LO: Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate. Proc Natl Acad Sci USA 1982; 79: 4148–4152.

    PubMed  Article  CAS  Google Scholar 

  24. Harding CV, Unanue ER: Antigen processing and intracellular Ia: Possible roles of endocytosis and protein synthesis in Ia function. J Immunol 1989; 142: 12–19.

    PubMed  CAS  Google Scholar 

  25. Snider MD, Rogers OC: Intracellular movement of cell surface receptors after endocytosis: Resialylation of asialo-transferrin receptor in human erythroleukemia cells. J Cell Biol 1985; 100: 826–834.

    PubMed  Article  CAS  Google Scholar 

  26. Krangel MS: Endocytosis and recycling of the T3-T cell receptor complex: The role of T3 phosphorylation. J Exp Med 1987; 165: 1141–1159.

    PubMed  Article  CAS  Google Scholar 

  27. Stein BS, Bensch KG, Sussman HH: Complete inhibition of transferrin recycling by monensin in K562 cells. J Biol Chem 1984; 259: 14762–14772.

    PubMed  CAS  Google Scholar 

  28. Cresswell P: Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis. Proc Natl Acad Sci USA 1985; 82: 8188–8192.

    PubMed  Article  CAS  Google Scholar 

  29. Pletscher M, Pernis B: Internalized membrane immunoglobulin meets intracytoplasmic DR antigen in human B-lymphoblastoid cells. Eur J Immunol 1983; 13: 581–584.

    PubMed  Article  CAS  Google Scholar 

  30. Tony HP, Phillips NE, Parker DC: Role of membrane immunoglobulin (Ig) crosslinking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation. J Exp Med 1985; 162: 1695–1708.

    PubMed  Article  CAS  Google Scholar 

  31. Lanzavecchia A: Antigen specific interactions between T and B cells. Nature 1985; 314: 537–539.

    PubMed  Article  CAS  Google Scholar 

  32. Machamer CE, Cresswell P: Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the α-β chain complex. Proc Natl Acad Sci USA 1984; 81: 1287–1291.

    PubMed  Article  CAS  Google Scholar 

  33. Nowell J, Quaranta V: Chloraquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chain from alpha-beta dimers in B cells. J Exp Med 1985; 162: 1371–1376.

    PubMed  Article  CAS  Google Scholar 

  34. Marks MS, Cresswell P: Invariant chain associates with HLA class II antigens via its extracytoplasmic region. J Immunol 1986; 136: 2519–2525.

    PubMed  CAS  Google Scholar 

  35. Blum JS, Cresswell P: Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc Natl Acad Sci USA 1988; 85: 3975–3979.

    PubMed  Article  CAS  Google Scholar 

  36. Elliott WL, Stille CJ, Thomas LJ, et al: An hypothesis on the binding of an amphipathic, α-helical sequence in Ii to the desetope of class II antigens. J Immunol 1987; 138: 2949–2952.

    PubMed  CAS  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Microbiology and Immunology, Duke University Medical Center, Durham, N.C., USA

    Peter Cresswell, Janice S. Blum, Janet E. Davis & Michael S. Marks

  2. Division of Immunology, Duke University Medical Center, Box 3010, 27710, Durham, NC, (USA)

    Peter Cresswell

Authors
  1. Peter Cresswell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Janice S. Blum
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Janet E. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael S. Marks
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cresswell, P., Blum, J.S., Davis, J.E. et al. Transport and expression of HLA class-II glycoproteins. Immunol Res 9, 190–199 (1990). https://doi.org/10.1007/BF02918178

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02918178

Keywords

  • Sialic Acid
  • Monensin
  • Endocytic Pathway
  • Invariant Chain
  • Neuraminidase Treatment