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Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

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Abstract

A major step towards understanding the basic mechanism of systemic lupus erythematosus (SLE), the prototypic autoimmune disease that developsspontaneously, has been the identification of nucleosomes as a primary immunogen in this disease. The production of pathogenic autoantibodies in SLE results from an MHC clas-II-restricted, cognate interaction between select populations of T helper cells and B cells that are specific for nucleosomal components. These observations pave the way for specific immunotherapy that blocks this pathogenic T and B cell interaction.

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Authors and Affiliations

  1. The Departments of Medicine and Microbiology-Immunology, Northwestern University Medical School, Chicago, Ill., USA

    Syamal K. Datta, Chandra Mohan & Ami Desai-Mehta

  2. Arthritis Division, Ward 3-315, Northwestern University Medical School, 303 East Chicago Avenue, 60611-3008, Chicago, IL, USA

    Syamal K. Datta

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Datta, S.K., Mohan, C. & Desai-Mehta, A. Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy. Immunol Res 14, 132–147 (1995). https://doi.org/10.1007/BF02918173

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