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Preclinical and clinical studies with the hematopoietic colony-stimulating factors and related interleukins

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References

  1. Broxmeyer, H.E.: Biomolecule-cell interactions and the regulation of myelopoiesis. Int. J. Cell Cloning4: 378–405 (1986).

    PubMed  CAS  Google Scholar 

  2. Broxmeyer, H.E.; Williams, D.E.: The production of myeloid blood cells and their regulation during health and disease. CRC crit. rev. Oncol. Hematol.8: 173–226 (1988).

    Article  CAS  Google Scholar 

  3. Broxmeyer, H.E.: Colony assays of hematopoietic progenitor cells and correlations to clinical situations. CRC crit. Rev. Oncol. Hematol.1: 227–257 (1983).

    Article  Google Scholar 

  4. Williams, D.E.; Lu, L.; Broxmeyer, H.E.: Characterization of hematopoietic stem and progenitor cells. Immunol. Res.6: 294–304 (1988).

    Google Scholar 

  5. Spangrude, G.J.; Heimfeld, S.; Weissman, I.L.: Purification and characterization of mouse hematopoietic stem cells. Science241: 58–62 (1988).

    Article  PubMed  CAS  Google Scholar 

  6. Williams, D.E.; Bicknell, D.C.; Cooper, S.; Shadduck, R.K.; Waheed, A.; Gillis, S.; Urdal, D.L.; Broxmeyer, H.E.: Interactions between purified murine colony stimulating factor (natural CSF-1, purified recombinant GM-CSF, and purified recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells. Exp. Hematol.15: 1007–1012 (1987).

    PubMed  CAS  Google Scholar 

  7. Clark, S.C.; Kamen, R.: The human hematopoietic colony-stimulating factors. Science236: 1229–1237 (1987).

    Article  PubMed  CAS  Google Scholar 

  8. Sieff, C.A.: Hematopoietic growth factors. J. clin. Invest.79: 1549–1557 (1987).

    Article  PubMed  CAS  Google Scholar 

  9. Cosman, D.: Colony stimulating factors in vivo and in vitro. Immunol. Today9: 97–98 (1988).

    Article  PubMed  CAS  Google Scholar 

  10. Broxmeyer, H.E.; Williams, D.E.: Actions of hematopoietic colony stimulating factors in vivo. Immunopathol. Res.6: 207–220 (1987).

    CAS  Google Scholar 

  11. Kindler, V.; Thorens, B.; de Kossodo, S.; Allet, B.; Eliason, J.F.; Thatcher, D.; Farber, N.; Vassalli, P.: Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleukin 3. Proc. natn. Acad. Sci. USA83: 1001–1005 (1986).

    Article  CAS  Google Scholar 

  12. Lord, B.I.; Malineux, G.; Testa N.G.; Keely, M.; Spooncer, E.; Dexter, T.M.: The kinetic response of hemopoietic precursors cells in vivo to high purified recombinant interleukin 3. Lymphokine Res.5: 97–104 (1986).

    PubMed  CAS  Google Scholar 

  13. Broxmeyer, H.E.; Williams, D.E.; Cooper, S.; Shadduck, R.K.; Gillis, S.; Waheed, A.; Urdal, D.L.; Bicknell, D.C.: The comparative effects in vivo of recombinant murine interleukin-3, natural murine colony stimulating factor-1 and recombinant murine granulocyte-macrophage colony stimulating factor on myelopoiesis in mice. J. clin. Invest.79: 721–730 (1986).

    Article  Google Scholar 

  14. Broxmeyer, H.E.; Williams, D.E.; Boswell, H.S.; Cooper, S.; Shadduck, R.K.; Gillis, S.; Waheed, A.; Urdal, D.L.: The effects in vivo of purified preparations of murine macrophage colony stimulating factor and natural and recombinant murine interleukin-3 without and with pretreatment of mice with purified iron-saturated human lactoferrin. Immunobiology172: 168–174 (1986).

    PubMed  CAS  Google Scholar 

  15. Broxmeyer, H.E.; Williams, D.E.; Cooper, S.: The influence in vivo of natural murine interleukin-3 on the proliferation of myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide. Leukemia Res.11: 201–205 (1987).

    Article  CAS  Google Scholar 

  16. Metcalf, D.; Begley, C.G.; Johnson, G.R.; Nicola, N.A.; Lopez, A.F.; Williamson, D.J.: Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood68: 46–57 (1986).

    PubMed  CAS  Google Scholar 

  17. Metcalf, D.; Begley, C.G.; Nicola, N.A.; Johnson, G.R.: Quantitative responses of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3). Exp. Hematol.15: 288–295 (1987).

    PubMed  CAS  Google Scholar 

  18. Lotem, J.; Sachs, L.: In vivo control of differentiation of myeloid leukemic cells by recombinant granulocyte-macrophage colony-stimulating factor and interleukin-3. Blood71: 375–382 (1988).

    PubMed  CAS  Google Scholar 

  19. Broxmeyer, H.E.; Williams, D.E.; Hangoc, G.; Cooper, S.; Gentile, P.S.; Shen, R-N.; Ralph, P.; Gillis, S.; Bicknell, D.C.: The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors. Blood Cells13: 31–48 (1987).

    PubMed  CAS  Google Scholar 

  20. Metcalf, D.; Begley, C.G.; Williamson, D.J.; Nice, E.C.; de Lamarter, J.; Mermod, J.J.; Thatcher, D.; Schmidz, A.: Hemopoietic responses in mice injected with purified recombinant murine GM-CSF. Exp. Hematol.15: 1–9 (1987).

    PubMed  CAS  Google Scholar 

  21. Blazar, B.R.; Widmer, M.B.; Soderling, C.C.B.; Gillis, S.; Vallera, D.A.: Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony stimulating factor following transplantation of T-cell depleted histoincompatible bone marrow. Blood72: 1148–1154 (1988).

    PubMed  CAS  Google Scholar 

  22. Donahue, R.E.; Wang, E.; Stone, D.K.; Kamen, R.; Wong, G.G.; Seghal, P.K.; Nathan, D.C.; Clark, S.C.: Stimulation of hematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature321: 872–875 (1986).

    Article  PubMed  CAS  Google Scholar 

  23. Mayer, P.; Lam, C.; Obenaus, H.; Liehl, E.; Besemer, J.: Recombinant human GM-CSF induces leukocytosis and activates peripheral blood polymorphonuclear neutrophils in non-human primates. Blood70: 206–213 (1987).

    PubMed  CAS  Google Scholar 

  24. Monroy, R.L.; Skelly, R.R.; MacVittie, T.J.; Davis, T.A.; Sauber, J.J.; Clark, S.C.; Donahue, R.E.; The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow. Blood70: 1696–1699 (1987).

    PubMed  CAS  Google Scholar 

  25. Monroy, R.L.; Skelly, R.R.; Taylor, P.; Dubois, A.; Donahue, R.E.: Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony stimulating factor. Exp. Hematol.16: 344–348 (1988).

    PubMed  CAS  Google Scholar 

  26. Broxmeyer, H.E.; Williams, D.E.; Cooper, S.: Hangoc, G.; Ralph, P.: Recombinant human granulocyte-colony stimulating factor and recombinant human macrophage-colony stimulating factor in vivo to enhance proliferation of granulocyte-macrophage, erythroid and multipotential progenitor cells in mice. J. cell. Biochem. (in press, 1988).

  27. Fujisawa, M.; Koboyashi, Y.; Okabe, T.; Takaku, F.; Komatsu, Y.; Itoh, S.: Recombinant human granulocyte colony-stimulating factor induces granulocytosis in vivo. Jap. J. Cancer Res.77: 866–869 (1986).

    CAS  Google Scholar 

  28. Tsuchuja, M.; Nomura, H.; Asano, S.; Kaziro, Y.; Nagata, S.: Characterization of recombinant human granulocyte colony-stimulating factor produced in mouse cells. EMBO J.6: 611–617 (1987).

    Google Scholar 

  29. Shimamura, M.; Kobayashi, Y.; Yuo, A.; Urabe, A.; Okabe, T.; Komatsu, Y.; Itoh, S.; Takaku, F.: Effect of human recombinant granulocyte colony-stimulating factor on hematopoietic injury in mice induced by 5 fluorouracil. Blood69: 353–355 (1985).

    Google Scholar 

  30. Moore, M.A.S.; Warren, D.J.: Synergy of interleukin 1 and granulocyte colony stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc. natn. Acad. Sci. USA84: 7134–7138 (1987).

    Article  CAS  Google Scholar 

  31. Cohen, A.M.; Zsebo, K.M.; Inove, H.; Hines, D.; Boone, T.C.; Chazin, V.R.; Tsai, L.; Ritch, T.; Souza, L.M.: In vivo stimulation of granulopoiesis by recombinant human granulocyte colony-stimulating factor. Proc. natn. Acad. Sci. USA84: 2484–2488 (1987).

    Article  CAS  Google Scholar 

  32. Welte, K.; Bonilla, M.A.; Gillio, A.P.; Boone, R.C.; Potter, G.K.; Gabrilove, J.L.; Moore, M.A.S.; O’Reilly, R.J.; Souza, L.M.: Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates. J. exp. Med.165: 941–948 (1987).

    Article  PubMed  CAS  Google Scholar 

  33. Welte, K.; Bonilla, M.A.; Gabrilove, J.L.; Gillio, A.P.; Potter, G.K.; Moore, M.A.S.; O’Reilly, R.J.; Boone, T.C.; Souza, L.M.: Recombinant human granulocyte-colony stimulating factor: In vitro and in vivo effects on myelopoiesis. Blood Cells13: 17–30 (1987).

    PubMed  CAS  Google Scholar 

  34. Broxmeyer, H.E.; Williams, D.E.; Cooper, S.; Waheed, A.; Shadduck, R.K.: The influence in vivo of murine colony stimulating factor-1 on myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide. Blood69: 913–918 (1987).

    PubMed  CAS  Google Scholar 

  35. Broxmeyer, H.E.; Williams, D.E.; Cooper, S.; Waheed, A.; Shadduck, R.K.: The effects in vivo of pure murine macrophage colony stimulating factor (CSF-1) in mice recovering from sublethal dosage of cyclophosphamide; in Baserga, Foa, Metcalf, Polli, Biological regulation of cell proliferation, pp. 147–151 (Raven Press, New York 1986).

    Google Scholar 

  36. Chikkappa, G.; Broxmeyer, H.E.; Cooper, S.; Williams, D.E.; Hangoc, G.; Greenberg, M.L.; Waheed, A.; Shadduck, R.K.: Effects in vivo of multiple injections of purified murine and recombinant human macrophage colony stimulating factor to mice. Cancer Res. (in press, 1989).

  37. Shadduck, R.K.; Waheed, A.; Boegel, F.; Pigoli, G.; Porcellini, A.; Rizzoli, V.: The effect of colony-stimulating factor-1 in vivo. Blood Cells13: 49–63 (1987).

    PubMed  CAS  Google Scholar 

  38. Broxmeyer, H.E.; Geissler, K.; Cooper, S.; Williams, D.E.: Influence of purified recombinant human macrophage colony stimulating factor in mice. Biotechnol. Ther. (in press, 1988).

  39. Neta, R.; Douches, S.; Oppenheim, J.J.: Interleukin 1 is a radioprotector. J. Immun.136: 2483–2485 (1986).

    PubMed  CAS  Google Scholar 

  40. Neta, R.; Oppenheim, J.J.; Douches, S.D.: Interdependence of the radioprotective effects of recombinant interleukin 1 alpha, tumor necrosis factor-alpha, granulocyte colony stimulating factor and murine recombinant granulocyte-macrophage colony-stimulating factor. J. Immun.140: 108–111 (1988).

    PubMed  CAS  Google Scholar 

  41. Neta, R.; Sztein, M.B.; Oppenheim, J.J.; Gillis, S.; Douches, S.D.: The in vivo effects of interleukin 1: bone marrow cells are induced to cycle after administration of interleukin 1. J. Immun.139: 1861–1866 (1987).

    PubMed  CAS  Google Scholar 

  42. Stork, L.C.; Peterson, V.M.; Rundus, C.J.; Robinson, W.A.: Interleukin-1 enhances murine myelopoiesis in vivo. Exp. Hematol.16: 163–167 (1988).

    PubMed  CAS  Google Scholar 

  43. Morrissey, P.; Charrier, K.; Bressler, L.; Albert, A.: The influence of IL-1 treatment on the reconstitution of the hemopoietic and immune systems after sublethal radiation. J. Immun.140: 4204–4210 (1988).

    PubMed  CAS  Google Scholar 

  44. Castelli, M.P.; Black, P.L.; Schneider, M.; Pennington, R.; Abe, F.; Talmadge, J.E.: Protective, restorative, and therapeutic properties of recombinant human IL-1 in rodent models. J. Immun.140: 3830–3837 (1988).

    PubMed  CAS  Google Scholar 

  45. Van der Meer, J.W.M.; Barza, M.; Wolff, S.M.: Dinarello, C.A.: A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gran-negative infection. Proc. natn. Acad. Sci. USA85: 1620–1623 (1988).

    Article  Google Scholar 

  46. Broxmeyer, H.E.; Cooper, S.: Influence in vivo of recombinant murine interleukin-4 and recombinant human granulocyte colony stimulating factor in mice (in preparation).

  47. Miyake, T.; Kung, CK-H; Goldwasser, E.: Purification of human erythropoietin. J. biol. Chem.252: 5558–5564 (1977).

    PubMed  CAS  Google Scholar 

  48. Al-Khatti, A.; Veith, R.W.; Papayannopoulou, T.; Fritsch, E.F.; Goldwasser, E.; Stamatoyannopoulos, G.: Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons. New Engl. J. Med.317: 415–420 (1987).

    PubMed  CAS  Google Scholar 

  49. Blazar, B.R.; Widmer, M.B.; Soderling, C.C.B.; Urdal, D.L.; Gillis, S.; Robinson, L.L.; Vallera, D.A.: Augmentation of donor bone marrow engraftment in histoincompatible murine recipients by granulocyte-macrophage colony-stimulating factor. Blood71: 320–328 (1988).

    PubMed  CAS  Google Scholar 

  50. Ishizaka, Y.; Motoyoshi, K.; Hatake, M.; Saito, M.; Takaku, F.: Mode of action of human urinary colony-stimulating factor. Exp. Hematol.14: 1–8 (1986).

    PubMed  CAS  Google Scholar 

  51. Metcalf, D.; Nicola, N.A.: Synthesis by mouse peritoneal cells of G-CSF, the differentiation inducer for myeloid leukemia cells: stimulation by endotoxin, M-CSF and multi-CSF. Leukemia Res.9: 35–50 (1985).

    Article  CAS  Google Scholar 

  52. Warren, M.K.; Ralph, P.: Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis and myeloid CSF. J. Immun.137: 2281–2285 (1986).

    PubMed  CAS  Google Scholar 

  53. Moore, R.N.; Oppenheim, J.J.; Farrar, J.J.; Carter, C.S., Jr.; Waheed, A.; Shadduck, R.K.: Production of lymphocyte activating factor (interleukin 1) by macrophages activated with colony stimulating factors. J. Immun.125: 1302–1305 (1980).

    PubMed  CAS  Google Scholar 

  54. Moore, R.N.; Larsen, H.S.; Horohov, D.W.; Rouse, B.T.: Endogenous regulation of macrophage proliferation expansion by colony stimulating factor induced interferon. Science223: 178–181 (1984).

    Article  PubMed  CAS  Google Scholar 

  55. Pelus, L.M.; Broxmeyer, H.E.; Kurland, J.I.; Moore, M.A.S.: Regulation of macrophage and granulocyte proliferation: Specificities of prostaglandin E and lactoferrin. J. exp. Med.150: 277–292 (1979).

    Article  PubMed  CAS  Google Scholar 

  56. Broxmeyer, H.E.; Juliano, L.; Waheed, A.; Shadduck, R.K.: Release from mouse macrophages of acidic isoferritins that suppress hematopoietic progenitor cells is induced by purified L-cell colony stimulating factors and suppressed by human lactoferrin. J. Immun.135: 3224–3231 (1985).

    PubMed  CAS  Google Scholar 

  57. Lu, L.; Walker, D.; Broxmeyer, H.E.; Hoffman, R.; Hu, W.; Walker, E.: Characterization of adult human marrow hematopoietic progenitors highly enriched by two-color sorting with MY10 and major histocompatibility (MHC) class II monoclonal antibodies. J. Immun.139: 1823–1829 (1987).

    PubMed  CAS  Google Scholar 

  58. Williams, D.E.; Cooper, S.; Broxmeyer, H.E.: The effects of hematopoietic suppressor molecules on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells (CFU-GM), Cancer Res.48: 1548–1550 (1988).

    PubMed  CAS  Google Scholar 

  59. Shadduck, R.K.; Waheed, A.; Wing, E.J.: Demonstration of a blood-bone marrow barrier to macrophage colony-stimulating factor (CSF-1). Blood (in press, 1988).

  60. Groopman, J.E.; Mitsuyasu, R.T.; DeLeo, M.J.; Oette, D.H.; Golde, D.W.: Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. New Engl. J. Med.317: 593–598 (1987).

    PubMed  CAS  Google Scholar 

  61. Vadhan-Raj, S.; Keating, M.; LeMaistre, A.; Hittleman, W.N.; McCredie, K.; Trujillo, J.M.; Broxmeyer, H.E.; Henney, C.; Gutterman, J.U.: Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome. New Engl. J. Med.317: 1545–1552 (1987).

    PubMed  CAS  Google Scholar 

  62. Ganser, A.; Volkers, B.; Greher, J.; Walther, F.; Hoelzer, D.: Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome—a phase I/II trial. Onkologie11: 53–55 (1988).

    PubMed  CAS  Google Scholar 

  63. Vadhan-Raj, S.; Buescher, S.; LeMaistre, A.; Keating, M.; Walters R.; Kantarjian, H.; Hittleman, W.N.; Broxmeyer, H.E.; Gutterman, J.U.: Stimulation of hematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte-macrophage colony-stimulating factor. Blood72: 134–141 (1988).

    PubMed  CAS  Google Scholar 

  64. Vadhan-Raj, S.; Buescher, S.; Broxmeyer, H.E.; LeMaistre, A.; Lepe-Zuniga, J.; Ventura, G.; Jeha, S.; Horowitz, L.; Trujillo, J.M.; Hittleman, W.N.; Gillis, S.; Gutterman, J.U.: Stimulation of myelopoiesis in patients with aplastic anemia by recombinant human granulocyte-macrophage colony-stimulating factor (submitted, 1988).

  65. Brandt, S.J.; Peters, W.P.; Atwater, S.K.; Kurtzberg, J.; Borowitz, M.J.; Jones, R.B.; Shpall, E.J.; Bast, R.C., Jr.; Gilbert, C.J.; Oette, D.H.: Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. New Engl. J. Med.318: 869–876 (1988).

    PubMed  CAS  Google Scholar 

  66. Blazar, B.R.; Kersey, J.H.; McGlave, F.B.; Vallera, D.A.; Lasky, L.C.; Haake, R.; Bostrum, B.; Weisdorf, D.R.; Epstein, C.; Ramsay, N.K.C.: In vivo administration of recombinant human granulocyte macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autographs: a phase I/II study (submitted, 1988).

  67. Peters, W.P.; Shogan, J.; Shpall, E.J.; Jones, R.B.; Kim, C.S.: Recombinant human granulocyte-macrophage colony-stimulating factor produces fever. Lanceti: 950 (1988).

    Article  Google Scholar 

  68. Metcalf, D.: Clonal analysis of the action of GM-CSF on the proliferation and differentiation of myelomonocytic leukemic cells. Int. J. Cancer24: 616–623 (1979).

    Article  PubMed  CAS  Google Scholar 

  69. Begley, C.G.; Metcalf, D.; Nicola, N.A.: Purified colony stimulating factors (G-CSF and GM-CSF) induce differentiation in human HL60 leukemic cells with suppression of clonogenicity. Int. J. Cancer39: 99–105 (1987).

    Article  PubMed  CAS  Google Scholar 

  70. Geissler, K.; Harrington, M.; Srivastava, C.; Leemhuis, T.; Tricot, G.; Broxmeyer, H.E.: Effects of recombinant human colony-stimulating factors (GM-CSF, G-CSF, and CSF-1) on human monocyte/macrophage differentiation (submitted, 1988).

  71. Gearing, D.P.; Gough, N.M.; King, J.A.; Hilton, D.J.; Nicola, N.A.; Simpson, R.J.; Nice, E.C.; Kelso, A.; Metcalf, D.: Molecular cloning and expression of a cDNA encoding a murine myeloid leukemia inhibitory factor (LIF). EMBO J.6: 3995–4001 (1987).

    PubMed  CAS  Google Scholar 

  72. Kasukabe, T.; Okabe-Kado, J.; Honma, Y.; Hozumi, M.: Purification of a novel growth inhibitory factor for partially differentiated myeloid leukemic cells. J. biol. Chem.263: 5431–5435 (1988).

    PubMed  CAS  Google Scholar 

  73. Gough, N.M.; Gearling, D.P.; King, J.A.; Willson T.A.; Hilton, D.J.; Nicola, N.A.; Metcalf, D.: Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor. Proc. natn. Acad. Sci. USA85: 2623–2627 (1988).

    Article  CAS  Google Scholar 

  74. Cannistra, S.A.; Rambaldi, A.; Spriggs, D.R.; Hermann, F.; Kufe, D.; Griffin, J.D.: Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal monocytes. J. clin. Invest.79: 1720–1728 (1987).

    Article  PubMed  CAS  Google Scholar 

  75. Geissler, K.; Tricot, G.; Leemhuis, T.; Walker, E.; Broxmeyer, H.E.: Recombinant human tumor necrosis factor-alpha and interferon-gamma induce monocyte-macrophage differentiation in vitro of blast cells from patients with acute myeloid leukemia myeloid blast crisis of chronic myeloid leukemia (submitted, 1988).

  76. Broxmeyer, H.E.; Lu, L.; Bicknell, D.C.; Williams, D.E.; Cooper, S.; Levi, S.; Salfeld, J.; Arosio, P.: The influence of purified recombinant human H-subunit and L-subunit ferritins on colony formation in vitro by granulocyte-macrophage and erythroid progenitor cells. Blood68: 1257–1263 (1986).

    PubMed  CAS  Google Scholar 

  77. Guimaraes, J.E.T.E.; Berney, J.J.; Broxmeyer, H.E.; Hoffbrand, A.V.; Francis, G.E.: Acidic isoferritin stimulates differentiation of normal granulomonocytic progenitors. Leukemia 2: 466–471 (1988).

    PubMed  CAS  Google Scholar 

  78. Vadhan-Raj, S.; Hittleman, W.N.; Ventura, C.; Buescher, S.; Keating, M.J.; Gutterman, J.U.: Granulocyte-macrophage colony stimulating factor and myelodysplastic syndromes (Letter). New Engl. J. Med.319: 51–53 (1988).

    Google Scholar 

  79. Griffin, J.D.; Herrmann, Y.F.; Wiper, D.; Wanger, K.; Sabbath, K.D.: Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia. Blood67: 1448–1453 (1986).

    PubMed  CAS  Google Scholar 

  80. Hoang, T.; Nora, N.; Wong, G.; Clark, S.; Minden, M.D.; McCulloch, E.A.: Effects of recombinant GM-CSF on the blast cells of acute myeloblastic leukemia. Blood68: 313–316 (1986).

    PubMed  CAS  Google Scholar 

  81. Broxmeyer, H.E.; Cooper, S.; Williams, D.E.; Hangoc, G.; Gutterman, J.U.; Vadhan-Raj, S.: Effects of purified recombinant human granulocyte-macrophage colony stimulating factor on growth characteristics of bone marrow hematopoietic progenitor/precursor cells in patients on a phase I clinical trial. Exp. Hematol.16: 594–602 (1988).

    PubMed  CAS  Google Scholar 

  82. Socinski, M.A.; Elias, A.; Schnipper, L.; Cannistra, S.A.; Antman, K.H.; Griffin, J.D.: Granulocyte-macrophage colony stimulating factor expands the circulating haemopoeitic progenitor cell compartment in man. Lanceti: 1194–1198 (1988).

    Article  Google Scholar 

  83. Gabrilove, J.L.; Jakubowski, A.; Scher, H.; Sternberg, C.; Wong, G.; Grous, J.; Yogoda, A.; Fain, K.; Moore, M.A.S.; Clarkson, B.; Oettgen, H.F.; Alton, K.; Welte, K.; Souza, L.: Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional cell carcinoma of the urothelium. New Engl. J. Med.318: 1414–1422 (1988).

    PubMed  CAS  Google Scholar 

  84. Bronchud, M.H.; Scarffe, J.H.; Thatcher, N.; Crowther, D.; Souza, L.M.; Alton, N.K.; Testa, N.G.; Dexter, T.M.: Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br. J. Cancer56: 809–813 (1987).

    PubMed  CAS  Google Scholar 

  85. Morstyn, G.; Souza, L.M.; Keech, J.; Sheridan, W.; Fox, R.; Campbell, L.; Alton, N.K.; Green, M.; Metcalf, D.: Effect of granulocyte colony-stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lanceti: 667–672 (1988).

    Article  Google Scholar 

  86. Komiyama, A.; Ishiguro, A.; Kubo, T.; Matsuoka, T.; Yasukohchi, S.; Yasui, K.; Yanagisawa, M.; Yamada, S.; Yamazaki, M.; Akabane, T.: Increases in neutrophil counts by purified human urinary colony-stimulating factor in chronic neutropenia of childhood. Blood71: 41–45 (1988).

    PubMed  CAS  Google Scholar 

  87. Motoyoshi, K.; Takaku, F.; Maekawa, T.; Miura, Y.; Kimura, K.; Furusawa, S.; Hattori, M.; Nomura, T.; Mizoguchi, H.; Ogawa, M.; Kinugsa, K.; Tominaga, T.; Shimoyama, M.; Deura, K.; Ohta, K.; Taguchi, T.; Masaoka, T.; Kimura, I.: Protective effect of partially purified human urinary colony-stimulating factor on granulocytopenia after antitumor chemotherapy. Exp. Hematol.14: 1069–1075 (1986).

    PubMed  CAS  Google Scholar 

  88. Wineoils, C.G.; Oliver, D.O.; Pippard, M.J.; Reid, C.; Downing, M.R.; Cotes, P.M.: Effect of human erythropietin derived from recombinant DNA on the anemias of patients maintained by chronic haemodialysis. Lancetii: 1175–1178 (1986).

    Google Scholar 

  89. Eschbach, J.W.; Egrie, J.C.; Downing, M.R.; Browne, J.K.; Adamson, J.W.: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. New Engl. J. Med.316: 73–78 (1987).

    PubMed  CAS  Google Scholar 

  90. Urabe, A.; Takaku, F.; Mizoguchi, H.; Kubo, K.; Ota, K.; Shimizu, N.; Tanakoa, K.; Nimura, N.; Nihei, H.; Koshikawa, S.; Akizawa, T.; Akiyama, N.; Otsubo, O.; Kawaguchi, Y.; Maeda, T.: Effect of recombinant human erythropoietin on the anemia of chronic renal failure. Int. J. Cell Cloning6: 179–191 (1988).

    Article  PubMed  CAS  Google Scholar 

  91. Erslev, A.: Erythropoietin coming of age. New Engl. J. Med.316: 101–103 (1987).

    PubMed  CAS  Google Scholar 

  92. Hangoc, G.; Lu, L.; Oliff, A.; Gillis, S.; Hu, W.; Bicknell, D.C.; Williams, D.E.; Broxmeyer, H.E.: Modulation of Friend virus infectivity in vitro by administration of purified preparations of human lactoferrin and recombinant murine interleukin-3 to mice. Leukemia1: 762–764 (1987).

    PubMed  CAS  Google Scholar 

  93. Lu, L.; Hangoc, G.; Oliff, A.; Chen, L.T.; Shen, R-N.; Broxmeyer, H.E.: The protective influence of lactoferrin on mice infected with the polycythemia inducing strain of the Friend virus complex. Cancer Res.47: 4184–4188 (1987).

    PubMed  CAS  Google Scholar 

  94. Gendelman, H.E.; Orenstein, J.M.; Martin, M.A.; Ferrua, C.; Mitra, R.; Phipps, T.; Wahl, L.A.; Lane, H.C.; Fauci, A.S.; Burke, D.S.; Skillman, D.; Meltzer, M.S.: Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J. exp. Med.167: 1428–1441 (1988).

    Article  PubMed  CAS  Google Scholar 

  95. Broxmeyer, H.E.; Williams, D.E.; Hangoc, G.; Cooper, S.; Gillis, S.; Shadduck, R.K.; Bicknell, D.C.: Synergistic myelopoietic action in vivo of combinations of purified natural murine colony stimulating factor-1, recombinant murine interleukin-3, and recombinant murine granulocyte-macrophage colony stimulating factor administered to mice. Proc. natn. Acad. Sci. USA84: 3871–3875 (1987).

    Article  CAS  Google Scholar 

  96. Williams, D.E.; Hangoc, G.; Cooper, S.; Boswell, H.S.; Shadduck, R.K.; Gillis, S.; Waheed, A.; Urdal, D.L.; Broxmeyer, H.E.: The in vivo effects of purified recombinant IL-3 and purified natural CSF-1 on murine high proliferative potential colony forming cells: Demonstration of in vivo synergism. Blood70: 401–403 (1987).

    PubMed  CAS  Google Scholar 

  97. Ikebuchi, K.; Wong, G.G.; Clark, S.C.; Ihle, J.N.; Hirai, Y.; Ogawa, M.: Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc. natn. Acad. Sci. USA84: 9035–9039 (1987).

    Article  CAS  Google Scholar 

  98. Caracciolo, D.; Shirsat, N.; Wong, G.G.; Lange, B.; Clark, S.C.; Rovera, G.: Recombinant human macrophage colony-stimulating factor (M-CSF) requires subliminal concentrations of granulocyte-macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro. J. exp. Med.166: 1851–1860 (1987).

    Article  PubMed  CAS  Google Scholar 

  99. Chen, B.D.M.; Clark, C.R.; Chou, T-H.: Granulocyte-macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony stimulating factor. Blood71: 997–1002 (1988).

    PubMed  CAS  Google Scholar 

  100. Broxmeyer, H.E.; Lu, L.; Cooper, S.; Schwall, R.H.; Mason, A.J.; Nikolics, K.: Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc. natn. Acad. Sci. USA85: 9052–9056 (1988).

    Article  CAS  Google Scholar 

  101. Lang, R.A.; Metcalf, D.; Cuthbertson, R.A.; Lyons, I.; Stanley, E.; Kelso, A.; Kannourakis, G.; Williamson, D.J.; Klintworth, G.K.; Gonda, T.J.; Dunn, A.R.: Transgenic mice expressing a hematopoietic growth factor gene (GM-CSF) develop accumulations of macrophage, blindness and a fatal syndrome of tissue damage. Cell51: 675–686 (1987).

    Article  PubMed  CAS  Google Scholar 

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Broxmeyer, H.E., Vadhan-Raj, S. Preclinical and clinical studies with the hematopoietic colony-stimulating factors and related interleukins. Immunol Res 8, 185–201 (1989). https://doi.org/10.1007/BF02918144

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