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Modulation of myelopoiesis by prostaglandin E2: Demonstration of a novel mechanism of action in vivo

  • Hematopoiesis, Symposium
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References

  1. Kurland J, Moore MAS: Modulation of hemo-poiesis by prostaglandins. Exp Hematol 1977; 5: 357–373.

    PubMed  CAS  Google Scholar 

  2. Pelus LM, Broxmeyer HE, More MAS: Regulation of human myelopoiesis by prostaglandin E and lactoferrin. Cell Tissue Kinet 1981;14:515–526.

    PubMed  CAS  Google Scholar 

  3. Kurland JI, Hadden JW, Moore MA: Role of cyclic nucleotides in the proliferation of committed granulocyte-macrophage progenitor cells. Cancer Res 1977;37:4534–4538.

    PubMed  CAS  Google Scholar 

  4. Taetle R, Koessler A: Effects of cyclic nucleotides and prostaglandins on normal and abnormal human myeloid progenitor proliferation. Cancer Res 1980;40:1223–1229.

    PubMed  CAS  Google Scholar 

  5. Pelus LM, Ottmann OG, Nocka KH: Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-α, β and γ and an effect mediated by tumor necrosis factor. J Immunol 1988;140:479–484.

    PubMed  CAS  Google Scholar 

  6. Williams DE, Cooper S, Broxmeyer HE: Effects of hematopoietic suppressor molecules on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells. Cancer Res 1988;48:1548–1550.

    PubMed  CAS  Google Scholar 

  7. Humes JL, Bonney RJ, Pelus LM, et al.: Macrophages synthesise and relaase prostaglandins in response to inflammatory stimuli. Nature 1977: 269:149–151.

    Article  PubMed  CAS  Google Scholar 

  8. Pelus LM, Bockman RS: Increased prostaglandin synthesis by macrophages from tumor-bearing mice. J Immunol 1979; 123:2118–2125.

    PubMed  CAS  Google Scholar 

  9. Golde DW, Cline MJ: Identification of the colony-stimulating cell in human peripheral blood. J Clin Invest 1972;51:2981–2983.

    Article  PubMed  CAS  Google Scholar 

  10. Chervenick PA, LoBuglio AF: Human blood monocytes: Stimulators of granulocyte and mononuclear colony formation in vitro. Science 1972; 178:164–166.

    Article  PubMed  CAS  Google Scholar 

  11. Kurland JI, Bockman RS, Broxmeyer HE, et al.: Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E. Science 1978;199:552–555.

    Article  PubMed  CAS  Google Scholar 

  12. Kurland JI, Broxmeyer HE, Pelus LM, et al: Role for monocyte-macrophage-derived colony-stimulating factor and prostaglandin E in the positive and negative feedback control of myeloid stem cell proliferation. Blood 1978;52:388–407.

    PubMed  CAS  Google Scholar 

  13. Pelus LM, Broxmeyer HE, Kurland JI, et al: Regulation of macrophage and granulocyte proliferation. Specificities of prostaglandin E and lactoferrin. J Exp Med 1979;150:277–292.

    Article  PubMed  CAS  Google Scholar 

  14. Williams N: Preferential inhibition of murine macrophage colony formation by prostaglandin E. Blood 1979;53:1089–1094.

    PubMed  CAS  Google Scholar 

  15. Kurland JI, Pelus LM, Ralph P, et al: Induction of prostaglandin E synthesis in normal and neoplastic macrophages: Role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation. Proc Natl Acad Sci USA 1979; 76:2326–2330.

    Article  PubMed  CAS  Google Scholar 

  16. Kincade PW, Lee G, Fernandes G, et al: Abnormalities in clonable B lymphocytes and myeloid progenitors in autoimmune NZB mice. Proc Natl Acad Sci USA 1979;76:3464–3468.

    Article  PubMed  CAS  Google Scholar 

  17. Aglietta M, Piacibello W, Gavosto F: Insensitivity of chronic myeloid leukemia cells to inhibition of growth by prostaglandin E1. Cancer Res 1980;40:2507–2511.

    PubMed  CAS  Google Scholar 

  18. Pelus LM, Broxmeyer HE, Clarkson BD, et al: Abnormal responsiveness of granulocyte-macrophage committed colony-forming cells from patients with chronic myeloid leukemia to inhibition by prostaglandin E1. Cancer Res 1980;40: 2512–2515.

    PubMed  CAS  Google Scholar 

  19. Gold EJ, Conjalka M, Pelus LM, et al: Marrow cytogenetic and cell-culture analyses of the myelo-dysplastic syndromes: Insights to pathophysiology and prognosis. J Clin Oncol 1983;1:627–634.

    PubMed  CAS  Google Scholar 

  20. Broudy VC, Kaushansky K, Harlan JM, et al: Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol 1987;139:464–468.

    PubMed  CAS  Google Scholar 

  21. Kaushansky K, Lin N, Adamson JW: Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest 1988;81: 92–97.

    Article  PubMed  CAS  Google Scholar 

  22. Bagby GC, McCall E, Berstrom KA, et al: A monokine regulates colony-stimulating activity production by vascular endothelial cells. Blood 1983;62:663–668.

    PubMed  CAS  Google Scholar 

  23. Zucali JR, Dinarello CA, Oblon DJ, et al: Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. J Clin Invest 1986;77:1857–1863.

    Article  PubMed  CAS  Google Scholar 

  24. Hancock WW, Pleau ME, Kobzik L: Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin. J Immunol 1988;140:3021–3025.

    PubMed  CAS  Google Scholar 

  25. Gentile P, Byer D, Pelus LM: In vivo modulation of murine myelopoiesis following intravenous administration of prostaglandin E2. Blood 1983;62: 1100–1107.

    PubMed  CAS  Google Scholar 

  26. Gentile PS, Pelus LM: In vivo modulation of myelopoiesis by prostaglandin E2. II. Inhibition of granulocyte-monocyte progenitor cell (CFU-GM) cell-cycle rate. Exp Hematol 1987;15:119–126.

    PubMed  CAS  Google Scholar 

  27. Jaffe BM, Behrman HR, Parker CW: Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. J Clin Invest 1973;52: 398–405.

    Article  PubMed  CAS  Google Scholar 

  28. Berenbaum MV, Cope WA, Bundick RV: Synergistic effect of cortisol and prostaglandin E2 on the PHA response. Relationship to immunosuppression induced by trauma. Clin Exp Immunol 1976;26:534–541.

    PubMed  CAS  Google Scholar 

  29. Anderson NH: Biological aspects of prostaglandins. Arch Intern Med 1974;133:30–50.

    Article  Google Scholar 

  30. Hamburg M, Samuelsson B: On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 1971;246:6713–6719.

    Google Scholar 

  31. Pelus LM: Association between colony-forming units granulocyte-macrophage expression of Ia-like (HLA-DR) antigen and control of granulocyte and macrophage production. A new role for prosta-glandin E. J Clin Invest 1982;70:568–578.

    Article  PubMed  CAS  Google Scholar 

  32. Broxmeyer HE: Acidic isoferritins and E-type prostaglandins in sources of colony stimulatory factors mask detection of cycling granulocyte-macrophage progenitor cells. Blood 1982;60: 1042–1045.

    PubMed  CAS  Google Scholar 

  33. Pardee AB, Dubrow R, Hamlin JL, et al: Animal cell cycle. Annu Rev Biochem 1978;47:715–750.

    Article  PubMed  CAS  Google Scholar 

  34. Pelus LM, Gentile PS: In vivo modulation of myelopoiesis by prostaglandin E2. III. Induction of suppressor cells in marrow and spleen capable of mediating inhibition of CFU-GM proliferation. Blood 1988;71:1633–1640.

    PubMed  CAS  Google Scholar 

  35. Gentile PS, Pelus LM: In vivo modulation of myelopoiesis by prostaglandin E2. IV. Prostaglandin E2 induction of myelopoietic inhibitory activity. J Immunol 1988;141:2714–2720.

    PubMed  CAS  Google Scholar 

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Supported by grant CA33225 from the National Cancer Institute, DHEW.

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Pelus, L.M. Modulation of myelopoiesis by prostaglandin E2: Demonstration of a novel mechanism of action in vivo. Immunol Res 8, 176–184 (1989). https://doi.org/10.1007/BF02918143

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