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Role of interleukin-1 in hematopoiesis

  • Hematopoiesis, Symposium
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Conclusions

IL-1 is considered a phylogenetically old molecule that predates the evolution of lymphocytes and immunoglobulins [35]. Its activities transcend immune function and encompass general inflammatory changes induced by pathogenic organisms. Depending upon the degree of endogenous activation of IL-1 production, its pleiotropic actions may be efficacious or deleterious. In so far as IL-1 has potential as a myelostimulatory agent in idiopathic or iatrogenic neutropenias, it has proved critical to define a dose and timing of administration designed to facilitate hematopoietic stimulation and yet avoid toxicity. Preclinical studies suggest that this is an attainable goal and clinical trials are currently underway.

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Authors and Affiliations

  1. James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, (USA)

    Malcolm A. S. Moore

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  1. Malcolm A. S. Moore
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Moore, M.A.S. Role of interleukin-1 in hematopoiesis. Immunol Res 8, 165–175 (1989). https://doi.org/10.1007/BF02918142

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