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Structure and expression of polypeptides encoded in the mouseQa region

  • Structure and Function of Major Histocompatibility Complex Class I Genes and Proteins (Part I), Symposium
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Conclusions

It is now clear that theQa region in mice encodes several class I molecules. In C57BL/10 mice, at least 6 of the 10 class I genes at theQa locus produce polypeptides. Some of the products are membrane-associated and some are secreted. As more Qa molecules are found, common structural features emerge. Sequence data show that they all have altered or truncated C termini, clearly distinguishing them from H-2 and other class I molecules. Their restricted tissue distribution suggests that they may be zonally distributed in the organism. It is now important to determine the molecular basis of this tissue specificity. With regard to their function, there are few clues at present, and we can only make correlations between the occurrence of Qa molecules and the cell types which produce them. The availability of large amounts of these molecules, produced by genetic manipulation, will enable us to test their properties in biological systems.

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  1. Department of Immunology, German Cancer Research Centre, Postfach 101 949, D-6900, Heidelberg, (FRG)

    Peter J. Robinson

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Robinson, P.J. Structure and expression of polypeptides encoded in the mouseQa region. Immunol Res 6, 46–56 (1987). https://doi.org/10.1007/BF02918103

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