Summary
C3H/He mice were found to be low responders in the contact sensitivity response to ABA. Intravenous injection of ABA-coupled syngeneic spleen cells induced hapten-specific Ts in C3H/He mice. These cells were Ts1 because they acted on the inductive phase of the contact sensitivity. They could suppress the contact sensitivity in H-2-compatible CBA mice which were known to be high responders to ABA. Using in vivo and in vitro systems for the induction of Ts, it was shown that I-A−J-J+Thy-1− adherent cells were necessary as APC for the induction of Ts1.
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Nakamura, Y., Nakamura, R.M. & Tokunaga, T. Cell-cell interaction responsible for the induction of first order suppressor T cells in hapten-specific contact sensitivity reactions. Immunol Res 5, 117–128 (1986). https://doi.org/10.1007/BF02917586
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DOI: https://doi.org/10.1007/BF02917586