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Effects of tin and lead on organ levels of essential minerals in rabbits

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Abstract

The effect of tin and lead on the levels of essential metals (Zn, Cu, Ca, Fe) in rabbit tissues was compared in relation to the route of administration. Animals received intraperitoneally, or per os, SnCl2 (2 mg Sn/kg) or Pb(CH3COO)2 (3.5 mg Pb/kg) every day for 5 d or for 1 mo. Copper, zinc, iron, and calcium were determined by AAS in the liver, kidneys, spleen, brain, bone marrow, and blood; lead and tin concentration were measured in the blood of animals. Tin and lead administered per os caused either no changes or the decreased concentration of endogenous metals in several tissues. The other route of administration (ip) of both metals generally contributed to the increased storage of essential elements. Blood tin levels of tin treated animals were only about ≲1/10 of blood lead concentrations of rabbits exposed to lead.

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Authors and Affiliations

  1. Department of Toxicological Chemistry, Institute of Environmental Research and Bioanalysis, Medical Academy of Łódź, Narutowicza 120a, 90-145, Łódź, Poland

    Grażyna Zaręba & Jadwiga Chmielnicka

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  1. Grażyna Zaręba
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  2. Jadwiga Chmielnicka
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Zaręba, G., Chmielnicka, J. Effects of tin and lead on organ levels of essential minerals in rabbits. Biol Trace Elem Res 20, 233–242 (1989). https://doi.org/10.1007/BF02917438

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  • DOI: https://doi.org/10.1007/BF02917438

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