Abstract
Chelating agents that have been or may be employed for the treatment of lead, iron, and aluminum overload conditions are described. Although EDTA has been used successfully for treatment of acute lead poisoning, superior ligands for this purpose can be developed. The use of desferriferrioxamine B (DFB) for the treatment of iron overload has several disadvantages, and superior iron chelators are now available. Aluminum overload may also be treated with DFB, but many superior ligands, including chelators designed for iron, are now available for clinical tests.
Similar content being viewed by others
References
C&En News, Aug. 8, 1988, p. 23/Aug. 15, 1988, p. 5.
J. C. Aub, A. M. Butler, R. K. Byers, H. Foreman, H. E. Harrison, B. Kissin, G. L. Maison, T. L. Shipman, and M. Rubin,Arch. Ind. Hyg. Occuptional Med. 7, 137 (1953).
H. S. Waxman and E. B. Brown,Progress in Hematology, E. Brown and C. V. More, eds., Grune and Stratton, New York, 1975.
W. F. Anderson and M. C. Hiller, Department of Health, Education and Welfare, Publication No. 77-994, Bethesda, MD, 1975.
A. E. Martell, R. J. Motekaitis, I. Murase, L. F. Sala, R. Stoldt, C. Y. Ng, H. Rosenkrantz, and J. J. Metterville,Inorg. Chim. Acta 138, 215 (1987).
C. G. Pitt, G. Gupta, W. E. Estes, H. Rosendrantz, J. J. Metterville, A. L. Crumbliss, R. A. Palmer, K. W. Nordquest, K. A. Sprinkle Hardy, D. R. Witcomb, B. R. Byers, J. E. Arceneaux, C. G. Gaines, and C. V. Sciortino,J. Pharmacol. Exp. Ther. 208, 12 (1979).
K. N. Raymond, V. L. Pecoraro, and F. L. Weitle,Development of Iron Chelators for Clinical Use, A. E. Martell, W. F. Anderson, and D. F. Badman, eds., Elsevier, New York, pp. 103–131, 1981.
H. Rosenkrantz and J. J. Metterville, Final Report to NIH, No. MRI-CA-06-85-13 (1985).
A. E. Martell and R. M. Smith,Critical Stability Constants, vols. 1–6, Plenum, New York, 1974, 1975, 1977, 1976, 1982, 1989.
A. Evers, R. D. Hancock, A. E. Martell, and R. J. Motekaitis,Inorg. Chem., in press.
R. D. Hancock and A. E. Martell,Comm. Inorg. Chem. 6, 237 (1988).
R. D. Hancock and A. E. Martell,Chem. Revs., submitted.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Martell, A.E. Complexation of labile metal ions and effect on toxicity. Biol Trace Elem Res 21, 295–303 (1989). https://doi.org/10.1007/BF02917267
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02917267