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Determination of aluminum levels in the kidney, liver, and brain of mice treated with aluminum hydroxide

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Abstract

In the present study, aluminum (Al) accumulation has been examined after aluminum loading in mice. The kidney, liver, and brain aluminum levels for mice that had been treated orally with aluminum hydroxide for 105 d and for the control group were determined using graphite furnace atomic absorption spectrophotometry (GFAAS) following an acid digestion. Matrix modifier consisted of 2% Triton X-100 and 2% Mg (NO3)2.

Al loaded mice showed a significant increase in tissue aluminum levels, relative to the control group.

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Authors and Affiliations

  1. Department of Pharm. Toxicology, Hacettepe University, 06100, Ankara, Turkey

    Gönül Şahin & S. Duru

  2. Department of Analytical Chemistry, Hacettepe University, 06100, Ankara, Turkey

    I. Varol & A. Temizer

  3. Department of Neurosurgery, Hacettepe University, 06100, Ankara, Turkey

    K. Benli

  4. Department of Pharmacology, Hacettepe University, 06100, Ankara, Turkey

    R. Demirdamar

Authors
  1. Gönül Şahin
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  2. I. Varol
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  3. A. Temizer
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  4. K. Benli
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  5. R. Demirdamar
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  6. S. Duru
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Şahin, G., Varol, I., Temizer, A. et al. Determination of aluminum levels in the kidney, liver, and brain of mice treated with aluminum hydroxide. Biol Trace Elem Res 41, 129–135 (1994). https://doi.org/10.1007/BF02917223

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  • DOI: https://doi.org/10.1007/BF02917223

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