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A histidine supplement and regulation of the zinc status in Swiss random mice

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Abstract

The effects of histidine on the zinc status are controversial. In mice, we studied the effects of a moderate histidine supplement on the regulation of the zinc status using subcutaneously administered65Zn. In animals fed a zinc-adequate diet, histidine supplement did not cause changes in the zinc status (zinc concentrations,65Zn tissue distribution, and tissue specific activities). Neither effects on the regulation of the zinc status (65Zn retention, excretion and biological half-life) could be demonstrated. However, the combination of a low zinc diet and moderate histidine supplementation caused changes in the regulation of the zinc status (lower65Zn retention, associated with increased fecal excretion and a shorter biological half-life), aggravating the dietary deficiency (lower bone zinc, a shift in the65Zn tissue distribution). Reviewing the literature, it seems that only a molar histidine/zinc ration of 2,000 or higher will cause zinc deficiency.

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Authors and Affiliations

  1. Department of Radiochemistry, Interfaculty Reactor Institute, Technical University at Delft, Mekelweg 15, 2629 JB, Delft, the Netherlands

    Jacobus P. Van Wouwe, Stefanie Hoogenkamp & Cornelis J. A. Van den Hamer

  2. Department of Paediatrics, State University of Leiden, PO Box 9600, 2300 RC, Leiden, the Netherlands

    Jacobus P. Van Wouwe

Authors
  1. Jacobus P. Van Wouwe
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  2. Stefanie Hoogenkamp
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  3. Cornelis J. A. Van den Hamer
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Van Wouwe, J.P., Hoogenkamp, S. & Van den Hamer, C.J.A. A histidine supplement and regulation of the zinc status in Swiss random mice. Biol Trace Elem Res 24, 207–216 (1990). https://doi.org/10.1007/BF02917208

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  • DOI: https://doi.org/10.1007/BF02917208

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