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Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2

  • Cellular Immunology, Symposium
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Conclusions

The studies described in this report demonstrate that NC activity is the function of a number of distinct effector cell populations and not due to a single type of NC cell. While IL-2 was found to augment the NC activity of all populations tested, in vitro culture and T-deficient mutant mouse studies would suggest that it is not necessary for maintaining NC activity. With NC being an ‘activity’ rather than the function of a single effector cell type, identifying all populations that lyse the WEHI-164 target as a single type of effector is no longer valid. As discussed previously, the same situation may apply to the NK compartment [43].

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Authors and Affiliations

  1. Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA

    Edmund C. Lattime, Michael J. Bykowsky & Osias Stutman

  2. Cellular Immunology, Memorial Sloan-Kattering Cancer Center, 1275 York Avenue, 10021, New York, NY, (USA)

    Edmund C. Lattime

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  1. Edmund C. Lattime
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  2. Michael J. Bykowsky
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  3. Osias Stutman
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Lattime, E.C., Bykowsky, M.J. & Stutman, O. Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2. Immunol Res 5, 5–15 (1986). https://doi.org/10.1007/BF02917189

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