Abstract
There is considerable evidence of an aluminum (Al)-calcium (Ca) interaction, including potentiation of Al accumulation and toxicity by Ca deficiency. To elucidate the influence of dietary Ca on Al absorption, rabbits were maintained on a low-Ca (0.024%) or a Ca-replete (0.83%) diet for 2 wk prior to testing. Once weekly, Al hydroxide, nitrate, citrate, or lactate or sucralfate was given orally, or Al lactate was given intravenously (iv). Oral Al bioavailability was determined by comparison of the area under the Al concentration-time curve to that obtained after iv Al. Neither oral Al bioavailability nor the pharmacokinetic parameters of iv Al lactate was significantly affected by dietary Ca concentration. When measured before the weekly Al treatments, total serum Ca of rabbits fed the low-Ca diet averaged 88% of rabbits fed the Ca-replete diet. Total serum Ca 1–72 h after Al treatment decreased from 1% (Al hydroxide) to 15% (Al citrate) below pretreatment concentrations.
Similar content being viewed by others
References
S. P. Andreoli, J. M. Bergstein, and D. J. Sherrard,N. Engl. J. Med. 310, 1079 (1984).
J. R. J. Sorenson, I. R. Campbell, L. B. Tepper, and R. D. Lingg,Environ. Health Perspect. 8, 3 (1974).
W. D. Kaehny, A. P. Hegg, and A. C. Alfrey,N. Engl. J. Med. 296, 1389 (1977).
P. Slanina, Y. Falkeborn, W. Frech, and A. Cedergren,Fd. Chem. Toxicol. 22, 391 (1984).
P. Slanina, W. Frech, L.-G. Ekstrom, L. Loof, S. Slorach, and A. Cedergren,Clin. Chem. 32, 539 (1986).
J. L. Greger, E. N. Bula, and E. T. Gum,J. Nutr. 115, 1708 (1985).
R. A. Yokel and P. J. McNamara,Toxicol. Appl. Pharmacol. 95, 32 (1988).
N. Partridge, J. L. White, and S. L. Hem,Pharmaceutical Res. 4, S-45 (1987).
J. D. Ownby and L. Dees,New Phytologist 101, 325 (1985).
C. Weis and A. Haug,Arch. Biochem. Biophys. 254, 304 (1987).
B. J. Farnell, U. DeBoni, and D. R. C. McLachlan,Exp. Neurol. 78, 241 (1982).
M. L. Koenig and R. S. Jope,J. Neurochem. 49, 316 (1987).
R. M. Garruto, R. Fukatsu, R. Yanagihara, D. C. Gajdusek, G. Hook, and C. E. Fiori,Proc. Natl. Acad. Sci. 81, 1875 (1984).
M. Taneda,Hokkaido J. Med. Sci. 59, 312 (1984).
M. Feinroth, M. V. Feinroth, and G. M. Berlyne,Min. Electrol. Metab. 8, 29 (1982).
R. A. Yokel and P. J. McNamara,Toxicol. Appl. Pharmacol. 77, 344 (1985).
R. E. Chapin and S. E. Smith,J. Anim. Sci. 26, 67 (1967).
O. Oster,Clin. Chim. Acta 114, 53 (1981).
M. Gibaldi and D. Perrier,Pharmacokinetics, second edition, Marcel Dekker, New York, NY, 1982.
R. R. Sokal and F. J. Rohlf,Biometry, second edition, W. H. Freeman, San Francisco, CA 1981.
J. E. Bourdeau, R. Bouillon, D. Zikos, and C. B. Langman,Min. Electrol. Metab. 14, 150 (1988).
R. A. Yokel and P. J. McNamara,Toxicol. Appl. Pharmacol. 99, 133 (1989).
H. Spencer and M. Lender,Gastroenterology 76, 603 (1979).
J. B. Cannata, B. J. R. Junor, J. D. Briggs, G. S. Fell, and G. Beastall,Lancet i, 501 (1983).
D. A. Henry, W. G. Goodman, R. K. Nudelman, N. C. DiDomenico, A. C. Alfrey, E. Slatopolsky, T. M. Stanley, and J. W. Coburn,Kidney Int. 25, 362 (1984).
V. G. Allen and J. P. Fontenot,J. Anim. Sci. 59, 798 (1984).
S. L. Buss and J. E. Bourdeau,Min. Elect. Metab. 10, 127 (1984).
S. D. Provan and R. A. Yokel,Biol. Trace Elem. Res.,23, 119 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yokel, R.A., McNamara, P.J. The influence of dietary calcium reduction on aluminum absorption and kinetics in the rabbit. Biol Trace Elem Res 23, 109–117 (1989). https://doi.org/10.1007/BF02917182
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02917182