Abstract
A novel transport measurement scheme of 60 base pairs of poly (dG) -poly (dC) DNA molecules using Au nanoparticles is devised and implemented. Thiol (-SH) terminations are synthesized at both 5’ and 3’ ends of the double stranded DNA molecules and they can be chemisorbed on the Au surface through sulfur atoms by covalent bonding. These thiol-modified ends make chemical bindings with Au nanoparticles and Au nano-gap electrodes, forming a stable electrode-DNA-nanoparticle-DNA-electrode conduction channel. This transport channel is self-formed and is stable due to robust bonding of thiol and Au. The current-voltage characteristic measured from our device shows a nonlinear behavior and the voltage gap is comparable to the result of previous experiment using the same molecules. This self-trapping method by thiol modified DNA molecules would also be a promising technique for efficient nanoparticle trapping.
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References
Aviram, A. and Ratner, M., 1974, “Molecular rectifiers,”Chem. Phys. Lett., Vol. 29, No. 2, pp. 277–283.
Bezryadin, A., Dekker, C. and Schmid, G., 1997, “Electrostatic Trapping of Single Conducting Nanoparticles Between Nanoelectrodes,”Appl. Phys. Lett., Vol. 71, No. 9, pp. 1273–1275.
Chae, J.-W. and Lee, Y.-S., 2004, “Modeling and Numerical Investigation of the Biomechanical Interaction for Human-Rifle System,”KSME International Journal, Vol. 18 No. 12, pp. 2069–2079.
Cuniberti, G., Craco, L., Porath, D. and Dekker, C., 2002, “Backbone-induced Semiconducting Behavior in Short DNA Wires,”Phys. Rev. B, Vol. 65, No. 24, 241314-1–4.
Dandliker, P. J., Holmlin, R. E. and Barton, J. K., 1997, “Oxidative Thymine Dimer Repair in the DNA Helix,”Science, Vol. 275, pp. 1465–1468.
Fink, H. W. and Schonenberger, C., 1999, “Electrical Conduction Through DNA Molecules,”Nature (Lond.), Vol. 398, pp. 407–410.
Gómez-Navarro, C., Moreno-Herrero, F., Pablo, P. J., Colchero, J., Gómez-Herrero, J. and Baró, A. M., 2000, “Contactless Experiments on Individual DNA Molecules Show no Evidence for Molecular Wire Behavior,”Proc. Natl. Acad. Sci. U.S.A., Vol. 99, No. 13, pp. 8484–8487.
Hwang, J. S., Kong, K. J., Ahn, D., Lee, G. S., Ahn, D. J. and Hwang, S. W., 2002, “Electrical Transport Through 60 Base Pairs of Poly (dG)-poly(dC) DNA Molecules,”Appl. Phys. Lett., Vol. 81, No. 6, pp. 1134–1136.
Hwang, J. S., Hwang, S. W. and Ahn, D., 2004, “Formation of Electrical Interconnects by Self-Trapping of Deoxyribonucleic Acid Molecules,”Jpn. J. Appl. Phys., Vol. 43, No. 6B, pp. 3803–3805.
Kasumov, A.Y., Kociak, M., Gueron, S., Reulet, B., Volkov, V. T., Klinov, D. V. and Bouchiat, H., 2001, “Proximity-Induced Superconductivity in DNA,”Science, Vol. 291, pp. 280–282.
Lee, K. W., Ban, J. S., Yu, Y. S. and Cho, K. Z., 2004, “A Study on the Mechanicam Properties of Ti-8Ta-3Nb Alloy for Biomaterials,”KSME International Journal, Vol. 18 No. 12, pp. 2204–2208.
Li, X.-Q. and Yan, Y. J., 2001, “Electrical Transport Through Individual DNA Molecules,”Appl. Phys. Lett., Vol. 79, No. 14, pp. 2190–2192.
Mirkin, C. A., Letsinger, R. L., Mucic, R. C. and Storhoff, J. J., 1996, “A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials,”Nature (Lond.), Vol. 382, No. 6592, pp. 607–609.
Okahata, Y., Kobayashi, T., Tanaka, K. and Shimomura, M., 1998, “Anisotropic Electric Conductivity in an Aligned DNA Cast Film,”J. Am. Chem. Soc., Vol. 120, No. 24, pp. 6165–6166.
Porath, D., Bezryadin, A., Vries, S. and Dekker, C., 2000, “Direct Measurement of Electrical Transport Through DNA Molecules,”Nature (Lond.), Vol. 403, pp. 635–638.
Reed, M. A., Zhou, C., Muller, C. J., Burgin, T. P. and Tour, J. M., 1997, “Conductance of a Molecular Junction,”Science, Vol. 278, pp. 252–254.
Reichert, J., Ochs, R., Beckmann, D., Weber, H. B., Mayor, M. and Lohneysen, H. V., 2002, “Driving Current Through Single Organic Molecules,”Phys. Rev. Lett., Vol. 88, No. 17, pp. 176804-1–4.
Storm, A. J., Van Noort, J., Vries, S. and Dekker, C., 2001, “Insulating Behavior for DNA Molecules Between Nanoelectrodes at the 100 nm Length Scale,”Appl. Phys. Lett., Vol. 79, No. 23, pp. 3881–3883.
Thiol-modified poly (dG) and poly (dC) DNA molecules were purchased from COSMO Co. Ltd., Seoul, Korea (website: http://www.cosmo4.com).
Weber, H. B., Reichert, J., Weigend, F., Ochs, R., Beckmann, D., Mayer, M., Ahlrichs, R. and Lohneysen, H. V., 2002, “Electronic Transport through Single Conjugated Molecules,”Chem. Phys., Vol. 281, No. 2-3, pp. 113–125.
Yaliraki, S. N., Kemp, M. and Ratner, M. A., 2002, “Conductance of Molecular Wires: Influence of Molecule-Electrode Binding,”J. Am. Chem. Soc., Vol. 121, No. 14, pp. 3428–3434.
Yoo, K.-H., Ha, D. H., Lee, J.-O., Park, J. W., Kim, J., Kim, J. J., Lee, H.-Y., Kawai, T. and Choi, H. Y., 2001, “Electrical Conduction Through Poly(dA)-Poly(dT) and Poly(dG)-Poly(dC) DNA Molecules,”Phys. Rev. Lett., Vol. 87, No. 19, pp. 198102-01–04.
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Hwang, J., Ahn, D., Hong, S. et al. Electrical conduction of thiol modified 60bp Poly(dG)-poly DNA molecules through Au nanoparticles. J Mech Sci Technol 19, 2138–2144 (2005). https://doi.org/10.1007/BF02916510
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DOI: https://doi.org/10.1007/BF02916510