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Desmin pathology in neuromuscular diseases

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Virchows Archiv B

Summary

Desmin is an intermediate filament protein that in striated muscle is normally located at Z-bands, beneath the sarcolemma, and prominently at neuromuscular junctions. It is abundant during myogenesis and in regenerating fibers, but decreases in amount with maturation; in regenerating and denervated muscle fibers it is co-expressed with vimentin. Aggregates of desmin occur as nonspecific cytoplasmic bodies or cytoplasmic spheroid complexes, similar to the aggregates of keratin filaments in Mallory bodies or the neurofilament aggregates in Lewy bodies. In all three instances, alpha-B crystallin may be associated with desmin. There are now increasing numbers of neuromuscular disorders in which abnormal amounts of desmin, some abnormally phosphorylated, feature prominently in muscle fibres. Several of these diseases, including spheroid body myopathy, granulo-filamentous body myopathy and the dystrophinopathies, are familial. Ultrastructural and immunohistochemical studies of desmin have considerably broadened our understanding of the pathology of the cytoskeleton in muscle fibers and in certain hereditary neuromuscular diseases.

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References

  • Altmannsberger M, Osborn M, Treuner J, Hölscher A, Weber K, Schauer A (1982) Diagnosis of human childhood rhabdomyosarcoma by antibodies to desmin, the structural protein of muscle-specific intermediate filaments. Virchows Arch [B] 39:203–215

    CAS  Google Scholar 

  • Arahata K, Ishiura S, Ishiguro T, Tsukahara T, Suhara Y, Eguchi C, Ishihara T, Nonaka I, Ozawa E, Sugita H (1988) Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide. Nature 333:861–863

    Article  PubMed  CAS  Google Scholar 

  • Askanas V, Bornemann A, Engel WK (1990) Immunocytochemical localization of desmin at human neuromuscular junctions. Neurology 40:949–953

    PubMed  CAS  Google Scholar 

  • Askanas V, Serdaroglu P, Engel WK, Alvarez RB (1991) Immunolocalization of ubiquitin in muscle biopsies of patients with inclusion body myositis and oculopharyngeal muscular dystrophy. Neurosci Lett 130:73–76

    Article  PubMed  CAS  Google Scholar 

  • Askanas V, Alvarez RB, McFerrin J, Serdaroglu P, Lew MF, Engel WK (1992) Facio-scapulo-humeral (FSH) syndrome with abnormal desmin accumulation: a new entity? Neurology 42:229 [Suppl 3]

    Google Scholar 

  • Babai F, Musevi-Aghdam J, Schurch W, Royal A (1990) Coexpression of alpha-sarcomeric actin, alpha-smooth muscle actin and desmin during myogenesis in rat and mouse embryos. I. Skeletal Muscle. Differentiation 44:132–142

    Article  PubMed  CAS  Google Scholar 

  • Bennett GS, Fellini SA, Toyama Y, Holtzer H (1979) Redistribution of intermediate filament subunits during skeletal myogenesis and maturation in vitro. J Cell Biol 82:577–584

    Article  PubMed  CAS  Google Scholar 

  • Bertini E, Bosman C, Ricci E, Servidei S, Boldrini R, Sabatelli M, Salviati G (1991) Neuromyopathy and restrictive cardiomyopathy with accumulation of intermediate filaments: a clinical, morphological and biochemical study. Acta Neuropathol (Berl) 81:632–640

    Article  CAS  Google Scholar 

  • Bindoff L, Cullen MJ (1978) Experimental (−)emetine myopathy. Ultrastructural and morphometric observations. J Neurol Sci 39:1–15

    Article  PubMed  CAS  Google Scholar 

  • Bornemann A, Schmalbruch H (1992) Desmin and vimentin in regenerating muscles. Muscle Nerve 15:14–20

    Article  PubMed  CAS  Google Scholar 

  • Bornemann A, Schmalbruch H (1993) Anti-vimentin staining in muscle pathology. Neuropathol Appl Neurobiol (in press)

  • Bradley WG, Fewings JD, Harris JB, Johnson MA (1976) Emetine myopathy in the rat. Br J Pharmacol 57:29–41

    PubMed  CAS  Google Scholar 

  • Carter RL, McCarthy KP, Machin LG, Jameson CF, Philp ER, Pinkerton CR (1989) Expression of desmin and myoglobin in rhabdomyosarcomas and in developing skeletal muscle. Histopathology 15:585–595

    Article  PubMed  CAS  Google Scholar 

  • Chapon F, Viader F, Fardeau M, Tomé F, Daluzeau N, Berthelin Ch, Thénint JPh, Lechevalier B (1989) Myopathie familiale avec inclusions de type “corps cytoplasmiques” (ou “sphéroides”) révélée par une insuffisance respiratoire. Rev Neurol (Paris) 145:460–465

    CAS  Google Scholar 

  • Chou SM, Mizuno Y (1986) Induction of spheroid cytoplasmic bodies in a rat muscle by local tetanus. Muscle Nerve 9:455–464

    Article  PubMed  CAS  Google Scholar 

  • Clark JR, D'Agostino AN, Wilson J, Brooks RR, Cole GC (1978) Autosomal dominant myofibrillar inclusion body myopathy: clinical, histologic, histochemical, and ultrastructural characteristics. Neurology 28:399

    Google Scholar 

  • Cullen JM, Fulthorpe JJ, Harris JB (1992) The distribution of desmin and titin in normal and dystrophic human muscle. Acta Neuropathol (Berl) 83:158–169

    Article  CAS  Google Scholar 

  • Dalakas MC, Illa I, Pezeshkpozur GH, Laukaitis JP (1990a) Can we distinguish AZT-induced myopathy from that due to HIV? Neurology 40:414 [Suppl 1]

    Google Scholar 

  • Dalakas MC, Illa I, Pezeshkpour GH, Laukaitis PJ, Cohen B, Griffin JL (1990b) Mitochondrial myopathy caused by longterm zidovudine therapy. N Engl J Med 322:1098–1105

    PubMed  CAS  Google Scholar 

  • Dalakas MC, Pezeshkpour GH (1988) Neuromuscular diseases associated with human immunodeficiency virus infection. Ann Neurol 23:S38-S48

    Article  PubMed  Google Scholar 

  • de Jong ASH, van Kessel-van Vark M, Albus-Lutter ChE, van Raamsdonk W, Voúte PA (1985) Skeletal muscle actin as tumor marker in the diagnosis of rhabdomyosarcoma in childhood. Am J Surg Pathol 9:467–474

    Article  PubMed  Google Scholar 

  • Duane DD, Engel AG (1970) Emetine myopathy. Neurology 20:733–739

    PubMed  CAS  Google Scholar 

  • Edström L, Thornell L-E, Eriksson A (1980) A new type of hereditary distal myopathy with characteristic sarcoplasmic bodies and intermediate (skeletin) filaments. J Neurol Sci 47:171–190

    Article  PubMed  Google Scholar 

  • Fardeau M, Godet-Guillain J, Tomé FMS, Collin H, Gaudeau S, Boffety CL, Vernant P (1978) Une nouvelle affection musculaire familiale, définie par l'accumulation intra-sarcoplasmique d'un matériel granulo-filamentaire dense en microscopie électronique. Rev Neurol (Paris) 134:411–425

    CAS  Google Scholar 

  • Fidzianska A, Goebel HH, Osborn M, Lenard HG, Osse G, Langenbeck U (1983) Mallory body-like inclusions in a hereditary congenital neuromuscular disease. Muscle Nerve 6:195–200

    Article  PubMed  CAS  Google Scholar 

  • Fürst DO, Osborn M, Weber K (1989) Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly. J Cell Biol 109:517–527

    Article  PubMed  Google Scholar 

  • Fukuhara N, Hoshi M, Moris S (1977) Core/targetoid fibres and multiple cytoplasmic bodies in organophosphate neuropathy. Acta Neuropathol (Berl) 40:137–144

    Article  CAS  Google Scholar 

  • Gallanti A, Prelle A, Moggio M, Ciscato P, Checcarelli N, Sciaccio M, Comini A, Scarlato C (1992) Desmin and vimentin as markers of regeneration in muscle diseases. Acta Neuropathol (Berl) 85:88–92

    Article  CAS  Google Scholar 

  • Gard DL, Lazarides E (1980) The synthesis and distribution of desmin and vimentin during myogenesis in vitro. Cell 19:263–275

    Article  PubMed  CAS  Google Scholar 

  • Geisler N, Weber K (1980) Purification of smooth-muscle desmin and a protein-chemical comparison of desmins from chicken gizzard and hog stomach. Eur J Biochem 111:425–433

    Article  PubMed  CAS  Google Scholar 

  • Goebel HH (1986) Neuropathological aspects of congenital myo-pathies. Progress in Neuropathology 6:231–262

    Google Scholar 

  • Goebel HH, Muller J, Gillen HW, Merrit AD (1978) Autosomal dominant “spheroid body myopathy”. Muscle Nerve 1:14–26

    Article  PubMed  CAS  Google Scholar 

  • Goebel HH, Schloon H, Lenard HG (1981) Congenital myopathy with cytoplasmic bodies. Neuropediatrics 12:166–180

    PubMed  CAS  Google Scholar 

  • Goebel HH, Halbig L, Voit T, Schober R, Klein H (1990) Familial inclusion body myopathy. 15th Oxford Symposium on Muscle Disease

  • Goebel HH, Lenard HG (1992) Congenital myopathies. In: Rowland LP, DiMauro S (eds) Handbook of clinical neurology, vol 18 (62): myopathies. Elsevier, Amsterdam, pp. 331–367

    Google Scholar 

  • Goebel HH, Voit T, Warlo I (1992) Immunohistochemical and electron microscopic abnormalities in dystrophin-related muscular dystrophy. J Neuropathol Exp Neurol 51:355

    Article  Google Scholar 

  • Granger BL, Lazarides E (1978) The existence of an insoluble Z disc scaffold in chicken skeletal muscle. Cell 15:1253–1268

    Article  PubMed  CAS  Google Scholar 

  • Granger BL, Lazarides E (1979) Desmin and vimentin coexist at the periphery of the myofibril Z disc. Cell 18 1053–1063

    Article  PubMed  CAS  Google Scholar 

  • Hall-Craggs ECB, Max SR, Wines MM, Moreland TM, Hebel JR (1983) Central core degeneration after tenotomy in soleus muscles of hyperthyroid rats. Exp Neurol 81: 722–732

    Article  PubMed  CAS  Google Scholar 

  • Halbig L, Goebel HH, Hopf HC, Moll R (1991) Spheroid-cytoplasmic complexes in a congenital myopathy. Rev Neurol (Paris) 147:300–307

    CAS  Google Scholar 

  • Hartung HP, Heininger K, Toyka KV (1988) Neuromuskuläre Manifestationen der HIV-1- und HTLV-I-Infektionen. Dtsch Med Wochenschr 113:1975–1981

    PubMed  CAS  Google Scholar 

  • Helliwell TR (1988) Lectin binding and desmin staining during bupivacaine-induced necrosis and regeneration in rat skeletal muscle. J Pathol 155:317–326

    Article  PubMed  CAS  Google Scholar 

  • Helliwell TR, Gunhan O, Edwards RHT (1989) Lectin binding and desmin expression during necrosis, regeneration, and neurogenic atrophy of human skeletal muscle. J Pathol 159:43–51

    Article  PubMed  CAS  Google Scholar 

  • Hill CS, Duran S, Lin Z, Weber K, Holtzer H (1986) Titin and myosin, but not desmin are linked during myofibrillogenesis in postmitotic mononucleated myoblasts. J Cell Biol 103:2185–2196

    Article  PubMed  CAS  Google Scholar 

  • Hoffman EP, Fischbeck KH, Brown RH, Johnson M, Medori R, Loike JD, Harris JB, Waterston R, Brooke M, Specht L, Kupsky W, Chamberlain J, Caskey CT, Shapiro F, Kunkel LM (1988) Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy. N Engl J Med 318:1363–1368

    PubMed  CAS  Google Scholar 

  • Hopf NJ, Goebel HH (1993) Experimental emetine myopathy: enzyme histochemical, electron microscopic, and immunomor-phological studies. Acta Neuropathol (Berl) 85:414–418

    Article  CAS  Google Scholar 

  • Hübner G, Pongratz D (1981) Granularkörpermyopathie (sog. Reducing body myopathy). Virchows Arch (A) 392:97–104

    Google Scholar 

  • Ishikawa H, Bischoff R, Holtzer H (1968) Mitosis and intermediate-sized filaments in developing skeletal muscle. J Cell Biol 38:538–555

    Article  PubMed  CAS  Google Scholar 

  • Jerusalem F, Ludin H, Bischoff A, Hartmann G (1979) Cytoplasmic body neuromyopathy presenting as respiratory failure and weight loss. J Neurol Sci 41:1–9

    Article  PubMed  CAS  Google Scholar 

  • Kaminska AM, Fidzianska A (1992) Immunofluorescent localization of vimentin and desmin intermediate filaments in regenerating rat skeletal muscle. Basic Applied Myol 2:27–31

    Google Scholar 

  • Kaufmann SJ, Foster RF (1988) Replicating myoblasts express a muscle-specific phenotype. Dev Biol 85:9606–9610

    Google Scholar 

  • Kelly DE (1969) Myofibrillogenesis and Z-band differentiation. Anat Rec 163:403–426

    Article  PubMed  CAS  Google Scholar 

  • Kinoshita M, Satoyoshi E, Suzuki Y (1975) Atypical myopathy with myofibrillar aggregates. Arch Neurol 32:417–420

    PubMed  CAS  Google Scholar 

  • Kobayashi K, Mizuno Y, Suzuki H, Takase S (1986) Clinicopathological study on familial cases of cytoplasmic body myopathy (in Japanese). Rinsho Shinkeigaku (Tokyo) 26:142 [Abstr]

    Google Scholar 

  • Lazarides E, Granger BL (1983) Transcytoplasmic integration in avian erythrocytes and striated muscle: the role of intermediate filaments. Mod Cell Biol 2:143–162

    CAS  Google Scholar 

  • Lehtonen E, Asikainen U, Badley RA (1982) Rhabdomyoma. Acta Pathol Microbiol Immunol Scand (Sect A) 90:125–129

    CAS  Google Scholar 

  • Li ZL, Lilienbaum A, Butter-Browne G, Paulin D (1989) Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development. Gene 78:243–254

    Article  PubMed  CAS  Google Scholar 

  • Lilienbaum A, Li ZL, Butter-Browne G, Bolmont C, Grimaud JA, Paulin D (1988) Human desmin gene: utilization as a marker of human muscle differentiation. Cell Mol Biol 34:663–672

    PubMed  CAS  Google Scholar 

  • Lowe J, McDermott H, Pike I, Spendlove I, Landon M, Mayer RJ (1992) Alpha-B crystallin expression in non-lenticular tissues and selective presence in ubiquitinated inclusion bodies in human disease. J Pathol 166:61–68

    Article  PubMed  CAS  Google Scholar 

  • MacDonald RD, Engel AG (1969) The cytoplasmic body: another structural anomaly of the Z disk. Acta Neuropathol (Berl) 14:99–107

    Article  CAS  Google Scholar 

  • Mateer JE, Farrell BJ, Chou SM, Gutmann L (1985) Reversible ipecac myopathy. Arch Neurol 42:188–190

    PubMed  CAS  Google Scholar 

  • Miettinen M, Lehto V-P, Badley RA, Virtanen I (1982) Alveolar rhabdomyosarcoma. Demonstration of the muscle type of intermediate filament protein, desmin, as a diagnostic aid. Am J Pathol 108:246–251

    PubMed  CAS  Google Scholar 

  • Misra AK, Menon NK, Mishra SK (1992) Abnormal distribution of desmin and vimentin in myofibres in adult onset myotubular myopathy. Muscle Nerve 15:1246–1252

    Article  PubMed  CAS  Google Scholar 

  • Mizuno Y, Nakamura Y, Komiya K (1989) The spectrum of cytoplasmic body myopathy: report on a congenital severe case. Brain Dev 1:20–25

    Google Scholar 

  • Nakashima N, Tamura Z, Okamoto S, Goto H (1970) Inclusion bodies in human neuromuscular disorder. Arch Neurol 22:270–278

    PubMed  CAS  Google Scholar 

  • Nicholson LVB, Johnson MA, Gardner-Medwin D, Bhattacharya S, Harris JB (1990) Heterogeneity of dystrophin expression in patients with Duchenne and Becker muscular dystrophy. Acta Neuropathol (Berl) 80:239–250

    Article  CAS  Google Scholar 

  • Osborn M, Goebel HH (1983) The cytoplasmic body in a congenital myopathy can be stained with antibodies to desmin, the muscle-specific intermediate filament protein. Acta Neuropathol (Berl) 62:149–152

    Article  CAS  Google Scholar 

  • Patel H, Berry K, MacLeod P, Dunn HG (1983) Cytoplasmic body myopathy. Report on a family and review of the literature. J Neurol Sci 60:281–292

    Article  PubMed  CAS  Google Scholar 

  • Paulus W, Slowik F, Jellinger K (1991) Primary intracranial sarcomas: histopathological features of 19 cases. Histopathology 18:395–402

    Article  PubMed  CAS  Google Scholar 

  • Pearce MB, Bullock RT, Murphy ML (1971) Selective damage of myocardial mitochondria due to emetine hydrochloride. Arch Pathol Lab Med 19:8–18

    Google Scholar 

  • Pellissier JF, Pouget J, Charpin C, Figarella D (1989) Myopathy associated with desmin type intermediate filaments. J Neurol Sci 89:49–61

    Article  PubMed  CAS  Google Scholar 

  • Porte A, Stoeckel M-E, Sacrez A, Batzenschlager A (1980) Unusual familial cardiomyopathy with storage of intermediate filaments in the cardiac muscular cells. Virchows Arch [A] 386:43–58

    Article  CAS  Google Scholar 

  • Prelle A, Moggio M, Comi GP, Gallanti A, Checcarelli N, Bresolin N, Ciscato P, Fortunato F, Scarlato G (1992) Congenital myopathy associated with abnormal accumulation of desmin and dystrophin. Neuromusc Disord 2:169–175

    Article  PubMed  CAS  Google Scholar 

  • Quax W, Meera Khan P, Quax-Jeuken Y, Bloemendal H (1985) The human desmin and vimentin genes are located on different chromosomes. Gene 38:189–196

    Article  PubMed  CAS  Google Scholar 

  • Rappaport L, Contard F, Samuel JL, Delcayre C, Marotte F, Tomé F, Fardeau M (1988) Storage of phosphorylated desmin in a familial myopathy. FEBS Lett 231:421–425

    Article  PubMed  CAS  Google Scholar 

  • Richardson FL, Stromer MH, Huiatt TW, Robson RM (1981) Immunoelectron and immunofluorescence localization of desmin in mature avian muscles. Eur J Cell Biol 26:91–101

    PubMed  CAS  Google Scholar 

  • Sarnat HB (1990) Myotubular myopathy: arrest of morphogenesis of myofibres associated with persistence of fetal vimentin and desmin. Four cases compared with fetal and neonatal muscle. Can J Neurol Sci 17:109–123

    PubMed  CAS  Google Scholar 

  • Sarnat HB (1992) Vimentin and desmin in maturing skeletal muscle and developmental myopathies. Neurology 42:1616–1624

    PubMed  CAS  Google Scholar 

  • Schiffer D, Giordana MT, Pezzotta S, Pezzulo T, Vigliani MC (1992) Medullomyoblastoma: report of two cases. Childs Nerv Syst 8:268–272

    Article  PubMed  CAS  Google Scholar 

  • Schmalbruch H (1976) The morphology of regeneration of skeletal muscles in the rat. Tissue Cell 8:673–692

    Article  PubMed  CAS  Google Scholar 

  • Schmalbruch H (1992) The muscular dystrophies. In: Mastaglia FL (ed) Skeletal muscle pathology. Churchill Livingstone, Edinburgh, pp 283–318

    Google Scholar 

  • Schröder JM, Sommer C, Schmidt B (1990) Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibres: immunocytochemical and fine structural studies, with a note on unusual 18-to 20-nm filaments. Acta Neuropathol (Berl) 80:406–414

    Article  Google Scholar 

  • Schultheiss T, Lin Z, Ishikawa H, Zamir I, Stoeckert CJ, Holtzer H (1991) Desmin/Vimentin intermediate filaments are dispensable for many aspects of myogenesis. J Cell Biol 114:953–966

    Article  PubMed  CAS  Google Scholar 

  • Stapleton SR, Harkness W, Wilkins PR, Uttley D (1992) Gliomyosarcoma: an immunohistochemical analysis. J Neurol Neurosurg Psychiatry 55:728–730

    PubMed  CAS  Google Scholar 

  • Stoeckel M-E, Osborn M, Porte A, Sacrez A, Batzenschlager A, Weber K (1981) An unusual familial cardiomyopathy characterized by aberrant accumulations of desmin-type intermediate filaments. Virchows Arch [A] 393:53–60

    Article  CAS  Google Scholar 

  • Taratuto AL, Molina HA, Diez B, Zúccaro G, Monges J (1985) Primary rhabdomyosarcoma of brain and cerebellum. Report of four cases in infants: an immunohistochemical study. Acta Neuropathol (Berl) 66:98–104

    Article  CAS  Google Scholar 

  • Telerman-Toppet N, Bauherz G, Noel S (1991) Auriculo-ventricular block and distal myopathy with rimmed vacuoles and desmin storage. Clin Neuropathol 10:61–64

    PubMed  CAS  Google Scholar 

  • Thornell LE, Edström L, Eriksson A, Henriksson KG, Ängqvist KA (1980) The distribution of intermediate filament protein (skeletin) in normal and diseased human muscle. An immunohistochemical and electron microscopic study. J Neurol Sci 47:153–170

    Article  PubMed  CAS  Google Scholar 

  • Thornell LE, Erikson A, Edström L (1983) Intermediate filaments in human myopathies. In: Dowben RB, Shay JW (eds) Cell Muscle Motil. Plenum, New York, pp 85–135

    Google Scholar 

  • Tidball JC (1992) Desmin at myotendinous junctions. Exp Cell Res 199:341–348

    Article  PubMed  CAS  Google Scholar 

  • Tokuyasu KT, Dutton AH, Singer SJ (1983) Immunoelectron microscopic studies of desmin (skeletin) localization and intermediate filament organization in chicken skeletal muscle. J Cell Biol 96:1727–1735

    Article  PubMed  CAS  Google Scholar 

  • Tokuyasu KT, Maher PA, Singer SJ (1984) Distributions of vimentin and desmin in developing chick myotubes in vivo. I. Immunofluorescence study. J Cell Biol 98:1961–1972

    Article  PubMed  CAS  Google Scholar 

  • Tokuyasu KT, Maher PA, Singer SJ (1985) Distributions of vimentin and desmin in developing chicken myotubes in vivo. II. Immunoelectron microscopic study. J Cell Biol 100:1157–1166

    Article  PubMed  CAS  Google Scholar 

  • Truong LD, Rangdaeng S, Cagle P, Ro JY, Hawkins H, Font RL (1990) The diagnostic utility of desmin. Clin Pathol 93:305–314

    CAS  Google Scholar 

  • Viegas-Péquignot E, Lin LZ, Dutrillaux B, Apiou F, Paulin D (1989) Assignment of human desmin gene to band 2q35 by nonradioactive in situ hybridization. Hum Genet 83:33–36

    Article  PubMed  Google Scholar 

  • Voit T, Krogmann O, Lenard HG, Neuen-Jacob E, Wechsler W, Goebel HH, Rahlf G, Lindinger A, Nienaber C (1988) Emery-Dreifuss muscular dystrophy: disease spectrum and differential diagnosis. Neuropediatrics 19:62–71

    Article  PubMed  CAS  Google Scholar 

  • Voit T, Stuettgen P, Cremer M, Goebel HH (1991) Dystrophin as a diagnostic marker in Duchenne and Becker muscular dystrophy. Correlation of immunofluorescence and Western blot. Neuropediatrics 22:152–162

    PubMed  CAS  Google Scholar 

  • Wolburg H, Schlote W, Langohr HD, Peiffer J, Reiher KH, Heckl RW (1982) Slowly progressive congenital myopathy with cytoplasmic bodies-report of two cases and a review of the literature. Clin Neuropathol 1:55–56

    PubMed  CAS  Google Scholar 

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  1. Division of Neuropathology, University of Mainz Medical Center, Langenbeckstrasse 1, D-55131, Mainz, Germany

    Hans H. Goebel & Antje Bornemann

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Goebel, H.H., Bornemann, A. Desmin pathology in neuromuscular diseases. Virchows Archiv B Cell Pathol 64, 127–135 (1993). https://doi.org/10.1007/BF02915105

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