Schizophrenia: Solving the puzzle

  • BD KellyEmail author
  • E O’Callaghan
  • A Lane
  • C Larkin
Short Paper


Background Schizophrenia is a common mental illness with an incidence of 15 new cases per 100,000 population per year.

Aim To review evidence for current neurodevelopmental models of the aetiology of schizophrenia.

Methods We performed a literature search using Medline and PsychINFO. We evaluated the relevance of each article and tracked other relevant articles through references.

Results There is considerable evidence to support neurodevelopmental models of the aetiology of schizophrenia. One or more aetiological events occur between conception and birth that disturb central nervous system (CNS) development, leading to persisting alterations in brain structure and function. These early events, acting in concert with genetic loading and later influences or insults, predispose to the development of schizophrenia in early adulthood.

Conclusions There have been considerable advances in schizophrenia research over the past 20 years. Future study of indices of neural development will help advance our understanding of this common, disabling mental illness.


Influenza Schizophrenia Traumatic Brain Injury Asylum Seeker Obstetric Complication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer London 2003

Authors and Affiliations

  1. 1.Stanley Research Unit, Department of Adult PsychiatryHospitaller Order of St John of God, Cluain Mhuire ServiceDublinIreland
  2. 2.Stanley Research FoundationSt John of God HospitalDublinIreland

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