Abstract
The studies cited herein highlight the potential benefits of IVIG therapy in a group of neurological disorders that are associated with aberrant immune responses. Indeed, all of the disorders discussed, except epilepsy, are associated with autoreactivity. The trials are preliminary and short-term and, except for idiopathic CIDP, uncontrolled. Interpretation of the findings of these uncontrolled studies is complicated by the fact that the natural history of all of these disorders is to show fluctuations, IVIG appears to be a potentially useful and safe agent in the treatment of patients with MG, intractable epilepsy, MS, and CIDP. Its place in the therapeutic approach to these neurological diseases must await the completion of controlled trials. Since other therapeutic modalities have already proven to be useful in several of these disorders, it will be important to determine if IVIG is more efficacious, safer, and more cost-effective. It is also worth considering whether the combination of IVIG and any of these more traditional approaches would provide added therapeutic benefit.
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Bussel, J. B. (1989),J. Allergy Clin. Immunol. 84, 566–578.
Pollock, S., Cunningham-Rundles, C., Smithwick, E. M., Barandun, S., and Good, R. (1982),N. Engl. J. Med. 307, 253.
Sultan, Y., Kazatchkine, M. D., Maisoneuve, P., and Nydegger, U. E. (1984),Lancet 2, 765–768.
Newburger, J. W., Takahashi, M., Burns, J. C., Beiser, A. S., Chung, K. J., Duffy, C. E., Glode, M. P., Mason, W. H., Reddy, V., Sanders, S. P., Shulman, S. T., Wiggins, J. W., Hicks, R. V., Fulton, D. R., Lewis, A. B., Leung, D. Y. M., Colton, T., Rasen, F. S., and Melish, M. E. (1986),N. Engl. J. Med. 315, 341–347.
Levinson, A. I., Zweiman, B., and Lisak, R. P. (1987),J. Clin. Immunol. 7, 187–197.
Gadjos, P., Outin, H. D., Elkharray, D., Brunei, P., DeRohan-Chabot, P., Raphael, J. C., Goulon, M., Goulon-Gorau, C., and Morel, E. (1984),Lancet 1, 406, 407.
Gadjos, P., Outin, H. D., Morel, E., Raphael, J. C., and Goulin, M. (1987),Ann. NY Acad. Sci. 505, 842–844.
Fateh-Moghadam, A., Wick, M., Besinger, U., and Guresen, R. G. (1984),Lancet 1, 848, 849.
Besinger, U. A., Gateh-Moghadam, A., Knorr, H., Wick, M., Kissel, H., and Albiez, M. (1987),Ann. NY Acad. Sci. 505, 828–831.
Arsura, E. L., Bick, A., Brunner, N. G., Namba, T., and Grob, D. (1986),Arch. Intern. Med. 146, 1365–1368.
Cook, L., Howard, J. F., and Folds, J. D. (1988),J. Clin. Immunol 8, 23–31.
Basta, M., Ianglios, P. F., Margues, M., Frank, M. M., and Fries, L. F. (1990),Blood 74, 326–333.
Kawada, K. and Terasaki, P. I. (1987),Exp. Hematol. 15, 133–136.
Stohl, W. (1986),J. Immunol 126, 4407.
Klinman, D. M. and Steinberg, A. D. (1986),Arthritis Rheum. 29, 697–705.
Hahn, B. H. and Ebling, R. M. (1984),J. Immunol. 132, 187–190.
Dietrich, G. and Kazatchkine, M. D. (1990),J. Clin. Invest 85, 620–625.
Rossi, F. and Kazatchkine, M. D. (1989),J. Immunol. 143, 4104–4109.
Leung, D. Y. M. (1989),J. Allergy Clin. Immunol. 84, 588–595.
Karpak, S. E., Graf, L., and Rapport, M. M. (1976),Science 194, 735–737.
Benson, M., Blennow, G., and Rosen, I. (1987),Acta Paediatr. Scand. 76, 147–150.
Seager, J., Jamiuson, D. L., Wilson, J., Hayward, A. R., and Soothill, J. F. (1975),Lancet 2, 632–635.
Duse, M., Tibert, S., Plebani, M., Avanzini, M. A., Gardenghi, M., Menegati, E., Monufgo, V., and Ugazio, A. G. (1986),Monogr. Allergy 20, 128–134.
Plebani, A., Avanzini, M. A., Gardenghi, M., Menegati, E., Monufo, V., and Ugazio, A. G. (1988),Monogr. Allergy 23, 204–215.
Pechadre, J. C., Sauvesie, B., Osier, C., and Gilbert, J. (1977),Rev. EEG Neurophysiol. Clin. 7, 443–447.
Laffont, F., Esnasult, S., Gilbert, A., Peytour, M. A., Cathola, H. P., and Eygonnet, J. P. (1979),Ann. Med. Interne (Paris) 130, 307–312.
Ariizume, M., Shihara, H., Hibio, S., Ryo, S., Babak, Ogawa, K., Suzuki, Y., and Momoki, T. (1983),Lancet 2, 162, 163.
Ariizume, M., Baba, K., Ogawa, K., et al. (1984),Hihon Univ. J. Med. 26, 229–242.
Echenne, B., Parayre-Chanez, M. J., Clat, J., and Baldy Moulkinier, M. (1987),Neuropediatrics 18, 126.
Sandstedt, P., Kostulas, V., and Larsson, L. E. (1984),Lancet 2, 1154, 1155.
Schwartz, S. A. (1989),J. Allergy. Clin Immunol. 84, 603–607.
Hartung, H. P., Heininger, K, Schafer, W. et al. (1988),Advances in Neuroimmunology (Raine, C, ed.),Ann. NY Acad. Sci.540, 122–161.
Dyck, P. J., Daube, J., O’Brien, P. C., et al. (1986),N. Engl. J. Med. 314, 461–465.
Kleyweg, R. P., van der Meche, F. G. A., and Meulstee, J.Neurology 38, 1639–1641.
Vermeulen, M., van der Meche, F. G. A., Speelman, J. D., Weber, A., and Busch, H. F. M. (1985),J. Neurol. Sci. 70, 317–326.
Faed, J. M., Day, M. B. B. S., Pollock, M., Taylor, P. K., Nukada, H., and Hammond-Tooke, G. D. (1989),Neurology 39, 422–425.
Albala, M., McNamara, M. E., Sokol, M., and Wyshock, E. (1987),Arch. Neurol. 44, 248, 249.
van Doorn, P. A., Brand, A., Strengers, P. F. W., Meulstee, J., and Vermeulen, M. (1990),Neurology 40, 209–212.
Dalakas, M. C. and Engel, W. K. (1981), Ann. Neurol. 9(Suppl.), 134–145.
Cook, D., Dalakas, M., Galdi, A., Biondi, D., and Porter, H. (1990),Neurology 40, 212–214.
van Doorn, P. A., Brand, A., and Vermeulen, M. (1988),Neurology,38, 1592–1595.
McFarland, H. F. (1988),Advances in Neuroimmunology (Raine, C, ed.),Ann. NY Acad. Sci.540, 99–105.
Rothfelder, U., Neu, I., and Pelka, R. (1982),Wochenschr. Med. 124, 74–78.
Schuller, E. and Govaerts, A. (1983),Wer. Neurol. 22, 205–212.
Soukop, W. and Tschabitscher, H. (1988),Wien Med. Wochenschr. 136, 477–480.
Henrikson, K. G. and Lindvall, B. (1990),Prog. Neurobiol. 35, 181–193.
Roifman, C. M., Schaffer, F. M., Wachsmuth, S. E., Murphy, G., and Gelfand, E. W. (1987),JAMA 255, 513–515.
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Levin son, A.I. The use of IVIG in neurological disease. Clinical Reviews in Allergy 10, 119–134 (1992). https://doi.org/10.1007/BF02914375
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DOI: https://doi.org/10.1007/BF02914375